INT44059

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Context Info
Confidence 0.06
First Reported 1984
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.75
Pain Relevance 2.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 2
Vom1r68 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
mu opioid receptor 4 100.00 Very High Very High Very High
medulla 11 99.96 Very High Very High Very High
Morphine 6 99.68 Very High Very High Very High
Periaqueductal grey 7 99.54 Very High Very High Very High
withdrawal 2 99.32 Very High Very High Very High
excitatory amino acid 1 98.16 Very High Very High Very High
Glutamate 1 97.16 Very High Very High Very High
gABA 2 96.24 Very High Very High Very High
antagonist 1 96.04 Very High Very High Very High
Cholecystokinin 8 95.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 7 99.54 Very High Very High Very High
Dysmenorrhea 1 83.36 Quite High
Spinal Cord Injury 1 75.60 Quite High
Increased Venous Pressure Under Development 2 54.88 Quite High
Opiate Addiction 1 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 1 5.00 Very Low Very Low Very Low
Pressure Volume 2 Under Development 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stimulation of the C1 area electrically, by local injection of the excitatory amino acid, L-glutamate, or with the GABA antagonist bicuculline, elevates arterial pressure (AP).
Positive_regulation (Stimulation) of C1 associated with gaba, glutamate, antagonist and excitatory amino acid
1) Confidence 0.06 Published 1984 Journal Clin Exp Hypertens A Section Abstract Doc Link 6365368 Disease Relevance 0.08 Pain Relevance 0.51
Moreover, the levels of C1 as well as those of C2 and C3 were markedly increased in the peripheral serum of day-21 rats within 15 min of LH administration.
Positive_regulation (increased) of C1
2) Confidence 0.03 Published 1984 Journal Endocrinology Section Abstract Doc Link 6697963 Disease Relevance 0.08 Pain Relevance 0.08
C1 neurons that contain mu-opioid receptors (MORs) are hyperpolarized by MOR activation and are activated during morphine withdrawal.
Positive_regulation (activated) of C1 in neurons associated with mu opioid receptor, withdrawal and morphine
3) Confidence 0.02 Published 2005 Journal Exp. Neurol. Section Abstract Doc Link 16194531 Disease Relevance 0 Pain Relevance 0.65
These results suggest that cardiovascular responses elicited by PAG stimulation occur via activation of non-C1 and C1 RVLM presympathetic neurons.
Positive_regulation (activation) of C1 in neurons associated with medulla and periaqueductal grey
4) Confidence 0.01 Published 2003 Journal J. Comp. Neurol. Section Abstract Doc Link 12975810 Disease Relevance 0.60 Pain Relevance 0.85

General Comments

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