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Context Info
Confidence 0.25
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.23
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
endothelial cells 1
HBA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 1 92.16 High High
Opioid 3 80.52 Quite High
opiate 3 80.08 Quite High
Morphine 1 75.00 Quite High
Enkephalin 2 55.12 Quite High
agonist 23 32.80 Quite Low
imagery 43 5.00 Very Low Very Low Very Low
positron emission tomography 15 5.00 Very Low Very Low Very Low
ischemia 15 5.00 Very Low Very Low Very Low
isoflurane 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperinsulinism 1 98.76 Very High Very High Very High
Hematuria 16 96.24 Very High Very High Very High
Benign Prostatic Hypertrophy 52 95.32 Very High Very High Very High
Opiate Addiction 1 92.52 High High
Hypoglycemia 9 91.12 High High
Dementia 1 89.64 High High
Congenital Anomalies 18 87.92 High High
Insulin Resistance 1 85.60 High High
Hyperglycemia 2 83.84 Quite High
Weight Gain 3 83.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Donohue and associates published their experience with 64 men scheduled to undergo TURP who were randomized to receive either 5 mg of finasteride or placebo daily for 2 weeks prior to surgery.23 Sections of prostatic urothelium were stained for VEGF expression and for CD31 to assess microvessel density (MVD) (an indicator of prostatic angiogenesis in patients with hematuria secondary to BPH).
Positive_regulation (stained) of CD31 associated with benign prostatic hypertrophy and hematuria
1) Confidence 0.25 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2710385 Disease Relevance 0.95 Pain Relevance 0
As expected, CD31 and CD144 were upregulated during the two-step differentiation and expressed robustly after sorting (Figure 2A).
Positive_regulation (upregulated) of CD31
2) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795856 Disease Relevance 0 Pain Relevance 0
Total RNA samples were isolated in Trizol (Invitrogen) followed by purification over a Qiagen RNeasy column (Qiagen) from undifferentiated hESCs, day 12 EBs, hESC-ECs (after CD31/CD144 sort), and HUVECs.
Positive_regulation (after) of CD31
3) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795856 Disease Relevance 0 Pain Relevance 0
Quantitative analysis showed after endothelial induction, ICAM1, CD31, VCAM1, and vWF were significantly upregulated, while FGF1, Flt1, KDR and VEGFA were expressed in undifferentiated cells and upregulated with endothelial differentiation of hESCs (Figure 4B), which were also consistent with the microarray data.
Positive_regulation (upregulated) of CD31
4) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2795856 Disease Relevance 0 Pain Relevance 0
In these subjects, it is possible to find increased concentrations of glycosylated hemoglobin A1 and a marked reduction of the acute insulin response to intravenous glucose, but not to arginine, which suggests a state of defective glucose recognition by pancreatic beta-cells during narcotic addiction.
Positive_regulation (increased) of hemoglobin A1 associated with addiction, hyperinsulinism and opiate addiction
5) Confidence 0.04 Published 1984 Journal Diabetes Care Section Abstract Doc Link 6368156 Disease Relevance 0.35 Pain Relevance 0.60
Immunohistochemical studies, especially those focusing on CD31 (an endothelial marker), CD34 (expressed by blood vascular endothelial cells), D2-40 and LYVE-1 (lymphatic endothalial cells), markers of vascular proliferation such as the MIB1 proliferative index and VEGF expression within the lesions, would appear to be more useful for subdividing, or on the contrary uniting, these pathological entities.
Positive_regulation (focusing) of CD31 in endothelial cells
6) Confidence 0.04 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2830950 Disease Relevance 0.35 Pain Relevance 0
It should be noted that DPP-4 inhibitors lower the HbA1c by approximately 1.0% and that other treatment options (namely insulin) should be considered, if the HbA1c is elevated by more than 1.0% or if metabolic control has decompensated.
Positive_regulation (elevated) of HbA1c
7) Confidence 0.01 Published 2010 Journal Pediatr Nephrol Section Body Doc Link PMC2874027 Disease Relevance 0.58 Pain Relevance 0

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