INT44109

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Context Info
Confidence 0.74
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.06
Pain Relevance 1.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Gad1) lyase activity (Gad1) intracellular (Gad1)
cytoplasm (Gad1)
Anatomy Link Frequency
neurons 2
caudate nucleus 1
testis 1
spinal cord 1
thoracic 1
Gad1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 4 100.00 Very High Very High Very High
noradrenaline 2 100.00 Very High Very High Very High
Neuropeptide 13 99.80 Very High Very High Very High
Enkephalin 8 99.56 Very High Very High Very High
GABAergic 33 98.98 Very High Very High Very High
gABA 69 98.92 Very High Very High Very High
Spinal cord 2 97.88 Very High Very High Very High
substance P 2 96.68 Very High Very High Very High
Dynorphin 2 95.16 Very High Very High Very High
Somatostatin 2 94.52 High High
Disease Link Frequency Relevance Heat
Generalized Anxiety Disorder 61 99.92 Very High Very High Very High
Bordatella Infection 2 84.48 Quite High
Disseminated Intravascular Coagulation 5 81.08 Quite High
Urological Neuroanatomy 4 75.28 Quite High
Primary Sclerosing Cholangitis 27 55.92 Quite High
Depression 19 5.00 Very Low Very Low Very Low
Sleep Disorders 11 5.00 Very Low Very Low Very Low
Aids-related Complex 7 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low
Hyperphagia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In keeping with evidence of a co-localization of GAD67 and preproenkephalin mRNAs in some striatal neurons, the results indicate that these two mRNAs can be differentially regulated in the same neurons.
Localization (co-localization) of GAD67 in neurons
1) Confidence 0.74 Published 1994 Journal Brain Res. Section Abstract Doc Link 8004444 Disease Relevance 0.17 Pain Relevance 0.23
Absence of co-localized glutamic acid decarboxylase and neuropeptides in noradrenergic axons of the rat spinal cord.
Localization (localized) of glutamic acid decarboxylase in spinal cord associated with neuropeptide and spinal cord
2) Confidence 0.67 Published 1997 Journal Brain Res. Section Title Doc Link 9070645 Disease Relevance 0.14 Pain Relevance 0.71
Patterns of co-localization of immunoreactivity for dopamine beta-hydroxylase (the synthetic enzyme for noradrenaline) and glutamic acid decarboxylase (the synthetic enzyme for GABA) or each one of six neuropeptides (neuropeptide Y, substance P, met-enkephalin, galanin, dynorphin A and somatostatin) were investigated with dual-colour confocal laser scanning microscopy in axons of cervical, thoracic and lumbar spinal segments of six adult rats.
Localization (co-localization) of glutamic acid decarboxylase in thoracic associated with dopamine, somatostatin, enkephalin, gaba, dynorphin, noradrenaline, neuropeptide and substance p
3) Confidence 0.67 Published 1997 Journal Brain Res. Section Abstract Doc Link 9070645 Disease Relevance 0.07 Pain Relevance 0.56
The localization of immunoreactive glutamic acid decarboxylase (GAD) and enkephalin-like immunoreactivity was examined in serial, 4-micron frozen sections of the caudate nucleus from rats pretreated with colchicine.
Localization (localization) of glutamic acid decarboxylase in caudate nucleus associated with generalized anxiety disorder and enkephalin
4) Confidence 0.64 Published 1984 Journal Brain Res. Section Abstract Doc Link 6375810 Disease Relevance 0.18 Pain Relevance 0.29
They were processed for MCH immunohistochemistry followed by GAD67 ISH using the same method as above.
Localization (followed) of GAD67 ISH
5) Confidence 0.59 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909908 Disease Relevance 0.25 Pain Relevance 0
The GABAergic system is also present in postnatal mouse testis: GAD67, VGAT and several GABAA receptor subunits in postnatal mouse testis
Localization (several) of GAD67 in testis associated with gabaergic
6) Confidence 0.41 Published 2004 Journal Reprod Biol Endocrinol Section Body Doc Link PMC416489 Disease Relevance 0.18 Pain Relevance 0.05
Second, this part roughly corresponds to "area 1" defined by Okada et al. [52] in which small neurons expressing VGLUT2 and GAD67 are localized, allowing comparison with a limited and defined group of cNTS neurons.
Localization (localized) of GAD67 in neurons
7) Confidence 0.30 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2978217 Disease Relevance 0.08 Pain Relevance 0.13

General Comments

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