INT44136

Context Info Confidence 0.69 First Reported 1984 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 8 Total Number 8 Disease Relevance 1.77 Pain Relevance 1.42

extracellular region (MLN) cell-cell signaling (MLN)

Anatomy Link Frequency plasma 2 foregut 1 gut 1 MLN (Homo sapiens)

Pain Link Frequency Relevance Heat Somatostatin 3 100.00 Cholecystokinin 1 99.56 antagonist 6 92.88 Pain 4 91.12 Calcium channel 1 88.00 qutenza 2 87.68 agonist 8 86.04 Calcitonin gene-related peptide 4 82.48 substance P 4 79.04 Bioavailability 1 78.16

Disease Link Frequency Relevance Heat Colitis 69 99.04 Renal Failure 2 97.24 Fecal Incontinence 3 92.44 Functional Bowel Disorder 4 91.40 Constipation 15 79.04 Irritable Bowel Syndrome / Irritable Bowel Syndrome Super 11 75.00 Disease 42 70.64 Pain 3 62.48 Ulcers 1 61.72 Toxicity 1 58.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

No pathological consequences of hypermotilemia have been described although elevated motilin levels have been found to be associated with some diarrheal states, renal failure, and in the first week following abdominal surgery.

Positive_regulation (elevated) of motilin associated with renal failure

1) Confidence 0.69 Published 1984 Journal Life Sci. Section Abstract Doc Link 6381948 Disease Relevance 0.10 Pain Relevance 0.06

Novel mechanisms to stimulate GI motility and transit include blockade of cholecystokinin (CCK)A receptors and stimulation of motilin receptors.

Positive_regulation (stimulation) of motilin associated with cholecystokinin

2) Confidence 0.53 Published 1999 Journal Can. J. Gastroenterol. Section Abstract Doc Link 10202210 Disease Relevance 0.27 Pain Relevance 0.78

Only in the dog is there strong evidence for an absolute requirement of motilin for the consolidation of the motor activity of the upper gut into the MMC.

Positive_regulation (requirement) of motilin in gut

3) Confidence 0.50 Published 1984 Journal Life Sci. Section Abstract Doc Link 6381948 Disease Relevance 0.07 Pain Relevance 0.10

This shows that the dose of erythromycin lactobionate used was adequate to stimulate the motilin receptors in the foregut.

Positive_regulation (stimulate) of motilin in foregut

4) Confidence 0.48 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2529327 Disease Relevance 0.25 Pain Relevance 0

Motilin plasma levels increase cyclically every 90–120 minutes during the interdigestive fasting period, and this cyclical release of motilin disappears after ingestion of a meal.

Positive_regulation (increase) of Motilin in plasma

5) Confidence 0.46 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925306 Disease Relevance 0 Pain Relevance 0

Local drug activation of the motilin receptors is thought to mediate much of the macrolide-related gastrointestinal side effects (Takeshita et al 2006).

Positive_regulation (activation) of motilin

6) Confidence 0.45 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676803 Disease Relevance 0.18 Pain Relevance 0.04

One of the gastrointestinal motility regulatory factors has been assumed to be the induction of changes in the levels of peptides (gastrin, somatostatin and motilin) in plasma.

Positive_regulation (induction) of motilin in plasma associated with somatostatin

7) Confidence 0.26 Published 2005 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 15969937 Disease Relevance 0 Pain Relevance 0.40

The numbers of MLN and LP DCs subsets expressing CXCL9 and CXCL11 after the onset of colitis were significantly increased during live Mycobacteria-enhanced colitis than in the other groups with the exception of MLN CXCL10+ myeloid DCs that were elevated following live bacterial challenge.

Positive_regulation (elevated) of MLN associated with colitis

8) Confidence 0.04 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 0.65 Pain Relevance 0.03

General Comments

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