INT44145

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Context Info
Confidence 0.40
First Reported 1984
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.50
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ace) peptidase activity (Ace) extracellular space (Ace)
extracellular region (Ace) plasma membrane (Ace)
Anatomy Link Frequency
lung 2
abdominal aorta 2
Ace (Rattus norvegicus)
Pain Link Frequency Relevance Heat
B1 receptor 91 99.46 Very High Very High Very High
Enkephalin 8 98.56 Very High Very High Very High
Angina 2 96.92 Very High Very High Very High
Inflammation 18 90.00 High High
cytokine 6 74.32 Quite High
antagonist 21 66.80 Quite High
fibrosis 2 58.32 Quite High
ischemia 1 54.32 Quite High
chemokine 4 51.68 Quite High
allodynia 21 50.00 Quite Low
Disease Link Frequency Relevance Heat
Nephritis 1 98.44 Very High Very High Very High
Stroke 2 98.16 Very High Very High Very High
Ureteral Obstruction 1 98.16 Very High Very High Very High
Cv General 3 Under Development 2 96.92 Very High Very High Very High
Myocardial Infarction 96 96.60 Very High Very High Very High
Atherosclerosis 4 94.32 High High
Cardiovascular Disease 2 91.92 High High
Targeted Disruption 8 90.80 High High
INFLAMMATION 19 90.00 High High
Coronary Heart Disease 8 89.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Angiotensin receptor blocker–ACE inhibitor combination therapy
Negative_regulation (blocker) of Gene_expression (therapy) of ACE
1) Confidence 0.40 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291334 Disease Relevance 1.08 Pain Relevance 0.10
Angiotensin receptor blocker–ACE inhibitor combination therapy
Negative_regulation (inhibitor) of Gene_expression (therapy) of ACE
2) Confidence 0.40 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291334 Disease Relevance 1.02 Pain Relevance 0.10
Captopril at doses which blocked conversion of angiotensin I to II inhibited the degradation of enkephalins across the lung.
Negative_regulation (blocked) of Gene_expression (conversion) of angiotensin I in lung associated with enkephalin
3) Confidence 0.33 Published 1984 Journal Life Sci. Section Abstract Doc Link 6384711 Disease Relevance 0 Pain Relevance 0.61
Morrissey and Klahr showed that ACE inhibition decreased NF-?
Negative_regulation (decreased) of Neg (inhibition) Gene_expression (inhibition) of ACE
4) Confidence 0.17 Published 2002 Journal BMC Cardiovasc Disord Section Body Doc Link PMC65512 Disease Relevance 1.13 Pain Relevance 0.11
For instance, genetic disruption of B1R or B2R and both receptors decreased ACE and ANG II AT1R function and expression in mice abdominal aorta, indicating that kinin receptors regulate AT1 receptors and ACE [76], [77].
Negative_regulation (decreased) of Gene_expression (expression) of ACE in abdominal aorta associated with b1 receptor
5) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 1.28 Pain Relevance 0.41

General Comments

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