INT44147

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Context Info
Confidence 0.50
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 9.02
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Agtr2) plasma membrane (Agtr2) transcription factor binding (Agtr2)
signal transducer activity (Agtr2)
Anatomy Link Frequency
blood 2
retina 2
pancreas 2
Agtr2 (Mus musculus)
Pain Link Frequency Relevance Heat
Endogenous opioid 5 99.76 Very High Very High Very High
Enkephalin 5 99.40 Very High Very High Very High
antagonist 20 99.28 Very High Very High Very High
narcan 3 97.00 Very High Very High Very High
Morphine 1 93.20 High High
Inflammation 29 74.32 Quite High
cytokine 16 73.28 Quite High
palliative 1 71.00 Quite High
anesthesia 8 5.00 Very Low Very Low Very Low
tetrodotoxin 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 252 99.98 Very High Very High Very High
Infection 138 99.98 Very High Very High Very High
Reprotox - General 1 4 99.88 Very High Very High Very High
Cytomegalovirus Infection 192 99.78 Very High Very High Very High
Apoptosis 34 99.78 Very High Very High Very High
Cancer 170 99.60 Very High Very High Very High
Hypertrophy 2 99.56 Very High Very High Very High
Stress 4 96.48 Very High Very High Very High
Pancreatic Cancer 42 96.28 Very High Very High Very High
Atherosclerotic Plaque 6 96.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intraventricular injection of angiotensin II in mice resulted in an increase in 1.5% NaCl intake, which was blocked by naloxone.
Positive_regulation (injection) of Gene_expression (injection) of angiotensin II associated with narcan
1) Confidence 0.50 Published 1984 Journal Appetite Section Abstract Doc Link 6385842 Disease Relevance 0.33 Pain Relevance 0.41
Since AT2 receptor expression has been noted in various stromal fibroblasts [23,24] and is inducible in the pancreas in pathological conditions [25], AT2 receptor deficiency may also influence pancreatic cancer growth.
Positive_regulation (inducible) of Gene_expression (expression) of AT2 receptor in pancreas associated with pancreatic cancer
2) Confidence 0.37 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2846883 Disease Relevance 0.73 Pain Relevance 0.04
The apoptotic index was lower in AT2-KO mouse tumors than in wild type mouse tumors
Positive_regulation (lower) of Gene_expression (lower) of AT2 associated with cancer and apoptosis
3) Confidence 0.35 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2846883 Disease Relevance 1.74 Pain Relevance 0
Augmented myocardial methionine-enkephalin in a murine model of cardiac angiotensin II-overexpression.
Positive_regulation (overexpression) of Gene_expression (overexpression) of angiotensin II associated with enkephalin
4) Confidence 0.24 Published 2007 Journal J Renin Angiotensin Aldosterone Syst Section Title Doc Link 18205093 Disease Relevance 0 Pain Relevance 0.29
Therefore, the objective of this present study was to assess the efficiency of paclitaxel palmitate-loaded anti-HER2 immunoemulsions, a targeted drug delivery system based on cationic emulsion covalently linked to anti-HER2 monoclonal antibody (Herceptin), in a well-established in vivo pharmacologic model of metastatic prostate cancer that overexpresses the HER2 receptor.
Positive_regulation (overexpresses) of Gene_expression (overexpresses) of HER2 receptor associated with reprotox - general 1
5) Confidence 0.23 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17210707 Disease Relevance 0.48 Pain Relevance 0.07
The goal of this investigation was to examine how cardiac levels of enkephalin production are altered in the development of normotensive primary hypertrophy due to elevated intra-cardiac angiotensin II (Ang II) production.
Positive_regulation (elevated) of Gene_expression (production) of angiotensin II associated with hypertrophy and enkephalin
6) Confidence 0.17 Published 2007 Journal J Renin Angiotensin Aldosterone Syst Section Abstract Doc Link 18205093 Disease Relevance 0.10 Pain Relevance 0.26
Diabetes-induced retinal production of angiotensin II and AT1R led to ERK activation.
Positive_regulation (induced) of Gene_expression (production) of angiotensin II associated with diabetes mellitus
7) Confidence 0.10 Published 2008 Journal Diabetes Section Body Doc Link PMC2494692 Disease Relevance 0.43 Pain Relevance 0
Diabetes-induced retinal production of angiotensin II and AT1R led to ERK activation.
Positive_regulation (led) of Gene_expression (production) of angiotensin II associated with diabetes mellitus
8) Confidence 0.10 Published 2008 Journal Diabetes Section Body Doc Link PMC2494692 Disease Relevance 0.43 Pain Relevance 0
Angiotensin-converting enzyme (ACE) inhibitors, prevent the conversion of angiotensin I to angiotensin II by ACE.
Positive_regulation (conversion) of Gene_expression (conversion) of angiotensin II
9) Confidence 0.08 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604899 Disease Relevance 0.37 Pain Relevance 0.13
In the diabetic retina, the production of angiotensin II and AT1R was upregulated, leading to ERK activation in the downstream of AT1R signaling (Fig. 1).
Positive_regulation (upregulated) of Gene_expression (production) of angiotensin II in retina associated with diabetes mellitus
10) Confidence 0.07 Published 2008 Journal Diabetes Section Body Doc Link PMC2494692 Disease Relevance 0.91 Pain Relevance 0
RESULTS—Induction of diabetes led to a significant increase in retinal production of angiotensin II and AT1R together with ERK activation in the downstream of AT1R.
Positive_regulation (increase) of Gene_expression (production) of angiotensin II associated with diabetes mellitus
11) Confidence 0.06 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2494692 Disease Relevance 0.55 Pain Relevance 0
Further studies show that CMV infection induces renin and angiotensin II (Ang II) expression in blood and in vessel cells, in a persistent infection manner.
Positive_regulation (induces) of Gene_expression (expression) of angiotensin II in blood associated with cytomegalovirus infection and infection
12) Confidence 0.04 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2673691 Disease Relevance 2.95 Pain Relevance 0.07

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