INT44149

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Context Info
Confidence 0.54
First Reported 1984
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.45
Pain Relevance 1.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Mif) cell proliferation (Mif) extracellular space (Mif)
aging (Mif) extracellular region (Mif) nucleus (Mif)
Anatomy Link Frequency
bladder 6
lymphocytes 3
macrophages 1
Mif (Rattus norvegicus)
Pain Link Frequency Relevance Heat
lidocaine 10 100.00 Very High Very High Very High
Spinal cord 63 99.06 Very High Very High Very High
Inflammation 65 98.64 Very High Very High Very High
cytokine 18 94.76 High High
Peripheral nervous system 9 89.16 High High
Central nervous system 14 46.16 Quite Low
Dorsal horn 30 36.32 Quite Low
Crohn's disease 3 29.04 Quite Low
Arthritis 3 28.04 Quite Low
substance P 21 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ocular Hypertension 94 99.82 Very High Very High Very High
INFLAMMATION 65 98.64 Very High Very High Very High
Endotoxemia 9 54.84 Quite High
Urological Neuroanatomy 12 50.72 Quite High
Ganglion Cysts 12 50.00 Quite Low
Hypertension 4 44.64 Quite Low
Reprotox - General 1 6 31.00 Quite Low
Asthma 3 30.20 Quite Low
Disease 8 29.04 Quite Low
Sepsis 3 28.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These differences in epithelial MIF staining within the bladder and the prostate suggest a change in MIF synthesis as epithelia undergo differentiation as has been reported for the eye lens [17].
Regulation (change) of Gene_expression (synthesis) of MIF in bladder
1) Confidence 0.54 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC184455 Disease Relevance 0.05 Pain Relevance 0.03
Our previous studies reported the anatomical localization for MIF only in the bladder, while the location of MIF in the peripheral ganglia (MPG; DRG) and in the lumbosacral spinal cord was not determined since the focus was on the change in MIF amounts in these tissues following bladder inflammation [10,11].
Regulation (change) of Gene_expression (amounts) of MIF in bladder associated with inflammation and spinal cord
2) Confidence 0.39 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC184455 Disease Relevance 0.50 Pain Relevance 0.41
In addition, there were changes in the levels of MIF and cyclooxygenase-2 in the central and peripheral nervous tissues that innervate the bladder and other pelvic viscera.
Regulation (changes) of Gene_expression (levels) of MIF in bladder
3) Confidence 0.27 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC184455 Disease Relevance 0.46 Pain Relevance 0.36
The elevated IOP was not altered by intravitreous injection of MIF or PBS (Fig. 5a).
Neg (not) Regulation (altered) of Gene_expression (injection) of MIF associated with ocular hypertension
4) Confidence 0.23 Published 2009 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2723674 Disease Relevance 1.43 Pain Relevance 0
Effect of lidocaine on production of migration inhibitory factor and on macrophage motility: in vitro exposure of guinea pig lymphocytes and macrophages.
Regulation (Effect) of Gene_expression (production) of migration inhibitory factor in lymphocytes associated with lidocaine
5) Confidence 0.22 Published 1984 Journal J. Leukoc. Biol. Section Title Doc Link 6387020 Disease Relevance 0 Pain Relevance 0.41
Effect of lidocaine on production of migration inhibitory factor and on macrophage motility: in vitro exposure of guinea pig lymphocytes and macrophages.
Regulation (Effect) of in macrophages Gene_expression (production) of migration inhibitory factor in lymphocytes associated with lidocaine
6) Confidence 0.08 Published 1984 Journal J. Leukoc. Biol. Section Title Doc Link 6387020 Disease Relevance 0 Pain Relevance 0.41

General Comments

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