INT44163

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Context Info
Confidence 0.78
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 69
Total Number 69
Disease Relevance 97.75
Pain Relevance 6.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ren1) extracellular space (Ren1) extracellular region (Ren1)
intracellular (Ren1) response to stress (Ren1)
Anatomy Link Frequency
blood 8
kidney 6
plasma 3
abdominal aorta 3
endothelial cells 2
Ren1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 730 100.00 Very High Very High Very High
cytokine 619 100.00 Very High Very High Very High
cINOD 22 99.82 Very High Very High Very High
COX2 10 99.42 Very High Very High Very High
cOX1 9 99.42 Very High Very High Very High
palliative 1 99.00 Very High Very High Very High
Bile 1 98.56 Very High Very High Very High
Clonidine 10 98.36 Very High Very High Very High
Analgesic 3 95.32 Very High Very High Very High
antagonist 46 89.72 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 816 100.00 Very High Very High Very High
Infection 5249 99.92 Very High Very High Very High
Pressure And Volume Under Development 2254 99.90 Very High Very High Very High
Chronic Renal Failure 384 99.88 Very High Very High Very High
Increased Venous Pressure Under Development 175 99.88 Very High Very High Very High
Cytomegalovirus Infection 7296 99.80 Very High Very High Very High
Targeted Disruption 96 99.66 Very High Very High Very High
Hypertension 104 99.62 Very High Very High Very High
Cancer 66 99.52 Very High Very High Very High
Coronary Artery Disease 60 99.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The up-regulation of the renin expression by aluminium is a strong indication of the influence of aluminium on the renin-angiotensin-aldosterone-system, resulting in possible induction of essential hypertension.
Gene_expression (expression) of renin associated with hypertension
1) Confidence 0.78 Published 2009 Journal J. Inorg. Biochem. Section Abstract Doc Link 19735944 Disease Relevance 0.09 Pain Relevance 0.08
Up-regulation in the expression of renin gene by the influence of aluminium.
Gene_expression (expression) of renin
2) Confidence 0.78 Published 2009 Journal J. Inorg. Biochem. Section Title Doc Link 19735944 Disease Relevance 0 Pain Relevance 0.10
These cells have a basal level expression of renin from the endogenous Ren-1c locus, and As4.1 cells are kidney cells.
Gene_expression (expression) of Ren-1c in kidney
3) Confidence 0.75 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 2.29 Pain Relevance 0.27
The authors studied homozygous Ren-2 rats that overexpress the murine Ren-2d renin gene, resulting in severe hypertension with end-organ damage [21, 22].
Gene_expression (overexpress) of renin associated with hypertension
4) Confidence 0.75 Published 2010 Journal Curr Heart Fail Rep Section Body Doc Link PMC2831188 Disease Relevance 0.46 Pain Relevance 0
The up-regulation of the renin expression by aluminium is a strong indication of the influence of aluminium on the renin-angiotensin-aldosterone-system, resulting in possible induction of essential hypertension.
Gene_expression (expression) of renin-angiotensin-aldosterone-system associated with hypertension
5) Confidence 0.67 Published 2009 Journal J. Inorg. Biochem. Section Abstract Doc Link 19735944 Disease Relevance 0.10 Pain Relevance 0.08
Immunohistochemical analysis of renin expression confirmed the above results.
Gene_expression (expression) of renin
6) Confidence 0.52 Published 2002 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 12184998 Disease Relevance 0 Pain Relevance 0.04
The current study examined further whether COX-1 is also involved in mediating ACEI-induced renin production.
Gene_expression (production) of renin
7) Confidence 0.52 Published 2002 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 12184998 Disease Relevance 0.09 Pain Relevance 0.09
Prostaglandins that increase renin production in response to ACE inhibition are not derived from cyclooxygenase-1.
Gene_expression (production) of renin associated with cox1
8) Confidence 0.52 Published 2002 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Title Doc Link 12184998 Disease Relevance 0.10 Pain Relevance 0.20
Therefore, we investigated if genetic deletion of COX-1 or EP(2) prevents increased ACEI-induced renin expression.
Gene_expression (expression) of renin
9) Confidence 0.52 Published 2002 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 12184998 Disease Relevance 0.07 Pain Relevance 0.07
Thus, CMV infection did not contribute to the mouse weight gain, but caused an increase of blood pressure apparently via a change in expression of cellular genes, the over expression of inflammatory cytokines, renin and Ang II in the vascular system.
Gene_expression (expression) of renin in vascular system associated with pressure and volume under development, inflammation, cytomegalovirus infection, weight gain, infection and cytokine
10) Confidence 0.50 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 1.98 Pain Relevance 0.10
To further define the relationship between MCMV infection and expression of renin, we performed a co-staining assay to measure MCMV infection inducing expression of renin at a single cell level.
Gene_expression (expression) of renin associated with cytomegalovirus infection and infection
11) Confidence 0.50 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 2.31 Pain Relevance 0.05
We infected As4.1 cells by MCMV in differing multiplicities of infection (MOI), and detected renin expression by immunofluorescent microscopy.
Gene_expression (expression) of renin associated with cytomegalovirus infection and infection
12) Confidence 0.50 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 2.38 Pain Relevance 0.17
These results suggest that CMV infection induced renin and Ang II expression, and this underlies a molecular mechanism by which CMV infection causes an increase of blood pressure.


Gene_expression (expression) of renin in blood associated with pressure and volume under development, cytomegalovirus infection and infection
13) Confidence 0.50 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 2.29 Pain Relevance 0.04
Cells with mock infection only had a basal level expression of renin.
Gene_expression (expression) of renin associated with infection
14) Confidence 0.50 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 2.49 Pain Relevance 0.12
We find that the induced renin expression occurred in MCMV infected cells only, and the MCMV antigens were co-localized with renin in the infected cells that were detected by antibodies specific to MCMV and renin, respectively (Fig. 4E–G).
Gene_expression (expression) of renin associated with cytomegalovirus infection
15) Confidence 0.50 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 2.19 Pain Relevance 0
Employing human umbilical vein (HUVEC, ATCC) and abdominal aorta endothelial cells (HAAE, ATCC), we found that HCMV infection stimulated expression of renin in EC in an infectious dose dependent manner, determined by expression of renin mRNA with Q-RT-PCR and expression of renin protein by Western blot (Fig. 7A–C).
Gene_expression (expression) of renin mRNA in abdominal aorta associated with cytomegalovirus infection and infection
16) Confidence 0.50 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 1.84 Pain Relevance 0.07
MCMV infection stimulates expression of renin
Gene_expression (expression) of renin associated with cytomegalovirus infection and infection
17) Confidence 0.50 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 2.21 Pain Relevance 0.51
To further define the relationship between MCMV infection and expression of renin, we performed a co-staining assay to measure MCMV infection inducing expression of renin at a single cell level.
Gene_expression (expression) of renin associated with cytomegalovirus infection and infection
18) Confidence 0.50 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 2.42 Pain Relevance 0.05
Employing human umbilical vein (HUVEC, ATCC) and abdominal aorta endothelial cells (HAAE, ATCC), we found that HCMV infection stimulated expression of renin in EC in an infectious dose dependent manner, determined by expression of renin mRNA with Q-RT-PCR and expression of renin protein by Western blot (Fig. 7A–C).
Gene_expression (expression) of renin in abdominal aorta associated with cytomegalovirus infection and infection
19) Confidence 0.50 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 1.85 Pain Relevance 0.07
When UV-inactivated MCMV was employed as a control in the infection, no increase in renin expression was detected (data not shown).


Gene_expression (expression) of renin associated with cytomegalovirus infection and infection
20) Confidence 0.50 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 2.33 Pain Relevance 0

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