INT44164

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Context Info
Confidence 0.49
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 10.53
Pain Relevance 1.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ren1) extracellular space (Ren1) extracellular region (Ren1)
intracellular (Ren1) response to stress (Ren1)
Anatomy Link Frequency
plasma 3
glomerulus 3
kidney 2
cardiac myocytes 1
afferent arteriole 1
Ren1 (Mus musculus)
Pain Link Frequency Relevance Heat
Clonidine 10 98.00 Very High Very High Very High
Potency 2 97.00 Very High Very High Very High
Bioavailability 8 96.24 Very High Very High Very High
fibrosis 14 86.32 High High
cINOD 12 73.52 Quite High
adenocard 4 70.84 Quite High
antagonist 40 67.92 Quite High
Inflammation 51 67.24 Quite High
Pain 4 60.64 Quite High
cytokine 21 45.36 Quite Low
Disease Link Frequency Relevance Heat
Cytomegalovirus Infection 192 99.64 Very High Very High Very High
Coronary Artery Disease 60 96.64 Very High Very High Very High
Cv Unclassified Under Development 135 95.72 Very High Very High Very High
Hypertension 69 95.40 Very High Very High Very High
Diabetes Mellitus 204 95.04 Very High Very High Very High
Coronary Heart Disease 46 93.92 High High
Infection 141 93.44 High High
Chronic Renal Failure 384 93.28 High High
Targeted Disruption 47 90.64 High High
Pressure And Volume Under Development 73 87.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We find that the induced renin expression occurred in MCMV infected cells only, and the MCMV antigens were co-localized with renin in the infected cells that were detected by antibodies specific to MCMV and renin, respectively (Fig. 4E–G).
Localization (localized) of renin associated with cytomegalovirus infection
1) Confidence 0.49 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 2.28 Pain Relevance 0
This phenomenon has been termed “ACE escape” and is likely due to a compensatory increase in plasma renin activity due to disruption of the feedback loop by which Ang II normally inhibits renin release [12].
Localization (release) of renin in plasma
2) Confidence 0.44 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.70 Pain Relevance 0
Likewise, ARBs increase plasma renin activity due to inhibition of the Ang II-renin release feedback loop [46].
Localization (release) of renin in plasma
3) Confidence 0.44 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.75 Pain Relevance 0
Renin is stored in secretory granules and is released in response to decreases in renal perfusion pressure, decreases in Cl- in the distal tubule fluid or increased sympathetic nerve stimulation via ?
Localization (released) of Renin in sympathetic
4) Confidence 0.44 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.37 Pain Relevance 0
The RAAS is a coordinated cascade of sequential enzymatic steps, the first of which is the release of renin from juxtaglomerular cells in the kidney.
Localization (release) of renin in kidney
5) Confidence 0.44 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.46 Pain Relevance 0
Renin release can also be inhibited by a direct action of angiotensin II on the juxtaglomerular cells.
Localization (release) of Renin in juxtaglomerular cells
6) Confidence 0.41 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.32 Pain Relevance 0
Many other factors are known to modify renin release and/or expression including vitamin D [13], uric acid [14], TGF?
Localization (release) of renin
7) Confidence 0.41 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.20 Pain Relevance 0
Furthermore, the recent release of direct renin inhibitors potentially may add even more information to the association of RAS and coronary atherosclerosis.
Localization (release) of renin associated with coronary artery disease
8) Confidence 0.29 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350139 Disease Relevance 1.06 Pain Relevance 0.03
To date, elucidation and release of an effective direct renin inhibitor have failed for multiple reasons, including achieving effective potency, poor oral bioavailability and high cost.
Localization (release) of renin associated with bioavailability and potency
9) Confidence 0.29 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350139 Disease Relevance 0.32 Pain Relevance 0.10
In contrast, EP4 messenger RNA is readily detected in the glomerulus where it may contribute to the regulation of renin release and decrease glomerular resistance.
Localization (release) of renin in glomerulus
10) Confidence 0.25 Published 2000 Journal Curr. Opin. Nephrol. Hypertens. Section Abstract Doc Link 10654821 Disease Relevance 0.49 Pain Relevance 0.07
The IP receptor mRNA is highly expressed near the glomerulus, in the afferent arteriole, where it may also dilate renal arterioles and stimulate renin release.
Localization (release) of renin in glomerulus
11) Confidence 0.22 Published 2001 Journal Annu. Rev. Physiol. Section Abstract Doc Link 11181968 Disease Relevance 0.45 Pain Relevance 0.16
In contrast, EP4 receptor mRNA is predominantly expressed in the glomerulus, where it may contribute to the regulation of glomerular hemodynamics and renin release.
Localization (release) of renin in glomerulus
12) Confidence 0.22 Published 2001 Journal Annu. Rev. Physiol. Section Abstract Doc Link 11181968 Disease Relevance 0.45 Pain Relevance 0.11
The IP receptor messenger RNA is most highly expressed in the afferent arteriole and it may also modulate renal arterial resistance and renin release.
Localization (release) of renin in afferent arteriole
13) Confidence 0.22 Published 2000 Journal Curr. Opin. Nephrol. Hypertens. Section Abstract Doc Link 10654821 Disease Relevance 0.52 Pain Relevance 0.16
PGs are modulators of physiological functions and contribute to REN release, regulation of renal microvascular hemodynamics, salt balance, and BP controlvia mechanisms involving the regulation of vascular tone and
Localization (release) of REN
14) Confidence 0.20 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1906712 Disease Relevance 0 Pain Relevance 0
In the kidney, prostaglandins (PGs) are important mediators of hemodynamic regulation, salt and water homeostasis, and REN release [9, 10].
Localization (release) of REN in kidney
15) Confidence 0.17 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1906712 Disease Relevance 0.49 Pain Relevance 0.09
It inhibits renin release and Ang II-stimulated aldosterone production [29, 31] and antagonizes the vasoconstrictor, sympathotonic, and antinatriuretic actions of Ang II [22], but also inhibits trophic effects of Ang II on cultured cardiac myocytes and fibroblasts [9].
Localization (release) of renin in fibroblasts
16) Confidence 0.10 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916114 Disease Relevance 0.38 Pain Relevance 0.04
secreted intothe systemic circulation and cleaved by REN and ACE to
Localization (secreted) of REN
17) Confidence 0.09 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1906712 Disease Relevance 0.80 Pain Relevance 0.06
It inhibits renin release and Ang II-stimulated aldosterone production [29, 31] and antagonizes the vasoconstrictor, sympathotonic, and antinatriuretic actions of Ang II [22], but also inhibits trophic effects of Ang II on cultured cardiac myocytes and fibroblasts [9].
Localization (release) of renin in cardiac myocytes
18) Confidence 0.04 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916114 Disease Relevance 0.38 Pain Relevance 0.04
[Growth hormone secretion and plasma renin activity in children following administration of clonidine].
Localization (secretion) of plasma renin in plasma associated with clonidine
19) Confidence 0.01 Published 1984 Journal Monatsschr Kinderheilkd Section Title Doc Link 6392861 Disease Relevance 0.13 Pain Relevance 0.61

General Comments

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