INT4418

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Context Info
Confidence 0.45
First Reported 1975
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.21
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ERAP1) peptidase activity (ERAP1) extracellular region (ERAP1)
endoplasmic reticulum (ERAP1)
Anatomy Link Frequency
covering 1
ERAP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 1 84.00 Quite High
spinal inflammation 9 50.00 Quite Low
Inflammatory response 1 41.84 Quite Low
Inflammation 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 6 99.42 Very High Very High Very High
Targeted Disruption 6 98.96 Very High Very High Very High
Low Back Pain 9 86.08 High High
Pancreatitis 1 84.00 Quite High
Gallstones 1 68.32 Quite High
Disease Susceptibility 2 60.40 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 4 53.60 Quite High
Cancer 4 48.08 Quite Low
INFLAMMATION 4 41.84 Quite Low
Psychosis 1 35.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Significant associations were also noted for 3 ERAP1 SNP variants (rs10050860, rs30187, and rs26653), although no significant haplotype interaction between ERAP1 and TAP/LMP loci was evident.
Positive_regulation (noted) of ERAP1
1) Confidence 0.45 Published 2009 Journal Arthritis Rheum. Section Body Doc Link 19404951 Disease Relevance 0.12 Pain Relevance 0
This result is consistent with the reduced MHC class I cell-surface expression observed after transient knock-down of ERAP1 or ERAP2 in cultured cells [48], the reduced MHC class I cell-surface expression seen in ERAP1-knock-out mice [54]–[56], [61], and our observation that ERAP1 is not upregulated to compensate for ERAP2 deficiency in cells from BB-homozygotes (Text S1).
Neg (not) Positive_regulation (upregulated) of ERAP1 associated with targeted disruption
2) Confidence 0.43 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0.37 Pain Relevance 0
The Sequenom iPlex platform was used to genotype cases and controls for 21 tag SNPs covering IL23R and 38 tag SNPs covering ERAP1.
Positive_regulation (covering) of ERAP1 in covering
3) Confidence 0.26 Published 2009 Journal Arthritis Rheum. Section Body Doc Link 19877036 Disease Relevance 0.09 Pain Relevance 0
Each LPG disease differed from all others by elevations of both leucine-aminopeptidase (LAP) and alkaline phosphatase (AP) levels.
Positive_regulation (elevations) of leucine-aminopeptidase associated with disease
4) Confidence 0.02 Published 1975 Journal South. Med. J. Section Abstract Doc Link 1162426 Disease Relevance 0.64 Pain Relevance 0.08

General Comments

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