INT4419

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Context Info
Confidence 0.65
First Reported 1975
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 22
Disease Relevance 22.53
Pain Relevance 2.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GOT1) small molecule metabolic process (GOT1) biosynthetic process (GOT1)
carbohydrate metabolic process (GOT1) cellular nitrogen compound metabolic process (GOT1) lysosome (GOT1)
Anatomy Link Frequency
liver 5
muscle 2
plasma 1
lymphocyte 1
GOT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 5 100.00 Very High Very High Very High
headache 15 98.24 Very High Very High Very High
cINOD 8 95.20 Very High Very High Very High
Chronic pancreatitis 1 94.96 High High
alcohol 12 93.56 High High
Inflammation 51 91.92 High High
Osteoarthritis 25 90.44 High High
visual analogue scale 11 89.68 High High
Paracetamol 36 89.28 High High
rheumatoid arthritis 160 88.00 High High
Disease Link Frequency Relevance Heat
Disorders Of Creatine Metabolism 2 100.00 Very High Very High Very High
Thrombocytopenia 42 99.60 Very High Very High Very High
Hepatotoxicity 65 99.58 Very High Very High Very High
Vomiting 10 99.40 Very High Very High Very High
Disease 284 99.36 Very High Very High Very High
Hypocalcemia 2 99.36 Very High Very High Very High
Anaemia 28 99.26 Very High Very High Very High
Sunburn 3 99.04 Very High Very High Very High
Fever 25 99.02 Very High Very High Very High
Liver Disease 21 99.02 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AST: Serum aspartate-aminotransferase
Gene_expression (AST) of aspartate-aminotransferase
1) Confidence 0.65 Published 2007 Journal Chin Med Section Body Doc Link PMC1852314 Disease Relevance 0.74 Pain Relevance 0.55
Elevated serum transaminase levels were observed in 24.7% of patients.
Gene_expression (levels) of serum transaminase
2) Confidence 0.32 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2768234 Disease Relevance 1.80 Pain Relevance 0.05
Short stature in 11 patients (10.9%), recurrent iron deficincy anemia in 16 patients (14.6%) and elevated transaminase levels in 1 patient (0.9%) were the only clinical features of CD.
Gene_expression (levels) of transaminase associated with celiac disease, anaemia and growth problems
3) Confidence 0.28 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2768234 Disease Relevance 1.11 Pain Relevance 0
Transient elevations in transaminase and creatine phosphokinase levels commonly occur.
Gene_expression (levels) of transaminase associated with disorders of creatine metabolism
4) Confidence 0.18 Published 1990 Journal Drugs Section Abstract Doc Link 2226216 Disease Relevance 1.17 Pain Relevance 0.10
Although conventional liver function tests are poor predictors of hepatic drug metabolism, there was a moderate correlation between plasma transaminase levels and measures of exogenous melatonin exposure.
Gene_expression (levels) of transaminase in plasma
5) Confidence 0.16 Published 2008 Journal Crit Care Section Body Doc Link PMC2447606 Disease Relevance 0.40 Pain Relevance 0.16
The levels of erythrocytes, haemoglobin, creatinine, serum glutamic pyruvic transaminase and lymphocyte levels were significantly lower in the exposed workers than in the non-exposed workers.
Gene_expression (levels) of transaminase in lymphocyte
6) Confidence 0.15 Published 2007 Journal Biomarkers Section Abstract Doc Link 17852074 Disease Relevance 0.86 Pain Relevance 0.08
To identify possible mechanisms of hepatotoxicity, we investigated liver function in vitro at > 170-fold of therapeutic C(max) levels, including cytotoxicity (lactate dehydrogenase, MTT, and ATP), transaminase activities (alanine aminotransferase and aspartate aminotransferase), albumin synthesis, urea and testosterone metabolism to assay for cytochrome P450 monooxygenase activity.
Gene_expression (activities) of transaminase in liver associated with hepatotoxicity
7) Confidence 0.12 Published 2009 Journal Toxicol. Sci. Section Abstract Doc Link 19770483 Disease Relevance 0.68 Pain Relevance 0.17
In all cases transaminase levels returned towards baseline levels with appropriate management (at least 6 discontinued altogether).
Gene_expression (levels) of transaminase
8) Confidence 0.11 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2725793 Disease Relevance 1.45 Pain Relevance 0.11
There was no significant liver disease seen, despite slight elevations of mean alanine transaminase and aspartate transaminase values.63
Gene_expression (values.63) of aspartate transaminase in liver associated with liver disease
9) Confidence 0.09 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2990387 Disease Relevance 0.75 Pain Relevance 0.16
There were more patients on a TCZ-DMARD combination than on TCZ monotherapy (8 mg/kg) or MTZ monotherapy who had elevations in aspartate transaminase and alanine transaminase.52
Gene_expression (alanine) of transaminase
10) Confidence 0.07 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2990387 Disease Relevance 0.32 Pain Relevance 0.03
The PT showed a weak association with transaminase levels only in the convalescent period (Spearman correlation = 0.2; both P < 0.05).


Gene_expression (levels) of transaminase
11) Confidence 0.07 Published 2010 Journal The American Journal of Tropical Medicine and Hygiene Section Body Doc Link PMC2946741 Disease Relevance 1.24 Pain Relevance 0
We also demonstrated only a weak correlation between PT and transaminase levels during the convalescent period, suggesting that liver synthetic function in terms of coagulation factor production was generally well compensated.
Gene_expression (levels) of transaminase in liver
12) Confidence 0.06 Published 2010 Journal The American Journal of Tropical Medicine and Hygiene Section Body Doc Link PMC2946741 Disease Relevance 1.18 Pain Relevance 0.03
We were unable to investigate specific muscle enzymes or isoforms in this study, but creatine kinase levels are known to be elevated during the acute phase of dengue infection.27 In combination with other simple laboratory tests, transaminase levels, particularly AST levels, have been suggested as a potential marker to help differentiate dengue from other viral infections during the early febrile phase.28 However, mild-to-moderate increases in transaminase levels, with AST higher than ALT levels, are a non-specific finding that may be observed in a number of other infections such as typhoid fever and malaria29,30 and in alcohol-related hepatitis.26
Gene_expression (levels) of transaminase in muscle associated with viral infection, dengue, fever, hepatitis, typhoid fever, infection and alcohol
13) Confidence 0.06 Published 2010 Journal The American Journal of Tropical Medicine and Hygiene Section Body Doc Link PMC2946741 Disease Relevance 1.38 Pain Relevance 0.04
In terms of correlation between transaminase levels and markers of disease severity, during the critical period, AST and ALT levels were significantly higher in the dengue patients who experienced shock compared with those without shock (P < 0.01, by Mann-Whitney test).
Gene_expression (levels) of transaminase associated with shock, dengue and disease
14) Confidence 0.06 Published 2010 Journal The American Journal of Tropical Medicine and Hygiene Section Body Doc Link PMC2946741 Disease Relevance 0.80 Pain Relevance 0
We were unable to investigate specific muscle enzymes or isoforms in this study, but creatine kinase levels are known to be elevated during the acute phase of dengue infection.27 In combination with other simple laboratory tests, transaminase levels, particularly AST levels, have been suggested as a potential marker to help differentiate dengue from other viral infections during the early febrile phase.28 However, mild-to-moderate increases in transaminase levels, with AST higher than ALT levels, are a non-specific finding that may be observed in a number of other infections such as typhoid fever and malaria29,30 and in alcohol-related hepatitis.26
Gene_expression (levels) of transaminase in muscle associated with viral infection, dengue, fever, hepatitis, typhoid fever, infection and alcohol
15) Confidence 0.06 Published 2010 Journal The American Journal of Tropical Medicine and Hygiene Section Body Doc Link PMC2946741 Disease Relevance 1.40 Pain Relevance 0.05
Newer formulations of photosensitizers were intended to reduce common side effects such as skin photosensitivity, nausea, vomiting and transiently raised liver transaminase levels.
Gene_expression (levels) of transaminase in liver associated with sunburn and vomiting
16) Confidence 0.06 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2212622 Disease Relevance 1.40 Pain Relevance 0.04
The compound administered, intravenously or subcutaneously, 3 times weekly did demonstrate a significant decrease in HCV RNA levels for a small sub-group of participants, however: many of the patients experienced frequent elevations in hepatic transaminase levels, raising doubts about the suitability of this drug [124].


Gene_expression (levels) of transaminase associated with hepatitis c virus infection
17) Confidence 0.04 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733095 Disease Relevance 1.99 Pain Relevance 0.12
Although the initial reports of GEM 91 clinical trials showed it to be well tolerated [117], its use was later discontinued because of dose-limiting thrombocytopenia and elevated serum transaminase levels.
Gene_expression (levels) of transaminase associated with thrombocytopenia
18) Confidence 0.04 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733095 Disease Relevance 1.43 Pain Relevance 0
There was no significant liver disease seen, despite slight elevations of mean alanine transaminase and aspartate transaminase values.63
Gene_expression (values.63) of transaminase in liver associated with liver disease
19) Confidence 0.03 Published 2010 Journal Drug Design, Development and Therapy Section Body Doc Link PMC2990387 Disease Relevance 0.75 Pain Relevance 0.17
The protective effects of methanol extract of SM were studied in carbon tetrachloride-reduced biochemical markers of hepatic injury such as glutamate pyruvate transaminase (SGPT), serum glutamate oxalaoacetate transaminase (SGOT), alkaline phosphatase (ALP), serum bilirubin, cholesterol alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels.
Gene_expression (levels) of serum glutamate oxalaoacetate transaminase associated with glutamate and injury
20) Confidence 0.01 Published 2010 Journal Pharmacognosy Magazine Section Abstract Doc Link PMC2900060 Disease Relevance 0.20 Pain Relevance 0.27

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