INT4420

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Context Info
Confidence 0.64
First Reported 1975
Last Reported 2010
Negated 4
Speculated 0
Reported most in Abstract
Documents 103
Total Number 103
Disease Relevance 88.40
Pain Relevance 18.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GOT1) small molecule metabolic process (GOT1) biosynthetic process (GOT1)
carbohydrate metabolic process (GOT1) cellular nitrogen compound metabolic process (GOT1) lysosome (GOT1)
Anatomy Link Frequency
liver 11
blood 3
upper 3
erythrocyte 2
skin 2
GOT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 22 100.00 Very High Very High Very High
Paracetamol 79 99.98 Very High Very High Very High
abdominal pain 54 99.90 Very High Very High Very High
addiction 11 99.88 Very High Very High Very High
cva 30 99.84 Very High Very High Very High
Pain 97 99.76 Very High Very High Very High
headache 44 99.64 Very High Very High Very High
alcohol 46 99.48 Very High Very High Very High
withdrawal 24 99.26 Very High Very High Very High
Inflammatory marker 8 99.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disorders Of Creatine Metabolism 17 100.00 Very High Very High Very High
Hepatotoxicity 139 99.96 Very High Very High Very High
Diarrhoea 67 99.96 Very High Very High Very High
Jaundice 60 99.96 Very High Very High Very High
Appetite Loss 14 99.96 Very High Very High Very High
Acid Base Imbalance 9 99.96 Very High Very High Very High
Hemolytic Anemia 1 99.96 Very High Very High Very High
Dengue 359 99.92 Very High Very High Very High
Hyperglycemia 50 99.92 Very High Very High Very High
Anaemia 80 99.90 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A case of gravida presenting with upper abdominal pain, an elevated serum glutamic oxaloacetic transaminase level, and thrombocytopenia, all of which resolved promptly after delivery, and with none of the standard signs and symptoms needed for the diagnosis of preeclampsia is presented.
Positive_regulation (elevated) of serum glutamic oxaloacetic transaminase in upper associated with abdominal pain, thrombocytopenia and pre-eclampsia
1) Confidence 0.64 Published 1985 Journal Obstet Gynecol Section Abstract Doc Link 4022510 Disease Relevance 0.44 Pain Relevance 0.10
A previously healthy 44-year-old man with well-documented normotension had a sudden onset of left flank pain and delayed onset of constitutional symptoms, hematuria, and elevations of lactic dehydrogenase, serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, and creatinine levels.
Positive_regulation (elevations) of transaminase associated with pain flank and hematuria
2) Confidence 0.59 Published 1984 Journal Am. J. Med. Section Abstract Doc Link 6720734 Disease Relevance 0.44 Pain Relevance 0.10
A previously healthy 44-year-old man with well-documented normotension had a sudden onset of left flank pain and delayed onset of constitutional symptoms, hematuria, and elevations of lactic dehydrogenase, serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, and creatinine levels.
Positive_regulation (elevations) of transaminase associated with pain flank and hematuria
3) Confidence 0.59 Published 1984 Journal Am. J. Med. Section Abstract Doc Link 6720734 Disease Relevance 0.44 Pain Relevance 0.10
Prolonged administration of phenylbutazone alone to rats for 21 days increased significantly serum glutamate oxalacetate transaminase (SGOT) activity, urea and creatinine concentrations, while it decreased with significance uric acid concentration in the serum.
Positive_regulation (increased) of serum glutamate oxalacetate transaminase associated with glutamate
4) Confidence 0.57 Published 1990 Journal Arch Exp Veterinarmed Section Abstract Doc Link 2096787 Disease Relevance 0.20 Pain Relevance 0.22
As for its tolerability, adverse reactions chiefly associated with affection of the gastrointestinal tract, i.e. nausea, stomach pain, diarrhea, increased transaminase levels were recorded.
Positive_regulation (increased) of transaminase in stomach associated with adverse drug reaction, pain, diarrhoea and vomiting
5) Confidence 0.56 Published 2000 Journal Antibiot. Khimioter. Section Abstract Doc Link 10851644 Disease Relevance 0.56 Pain Relevance 0.10
The clinical presentation of lactic acid syndrome is non-specific and includes asthenia, malaise, nausea, vomiting, abdominal pain, weight loss, tachypnoea, dyspnoea, liver steatosis and increased transaminase levels, and risk factors include previous or concurrent therapy with stavudine or didanosine.
Positive_regulation (increased) of transaminase in liver associated with fatty liver, abdominal pain, weight loss, syndrome, vomiting, dyspnea and asthenia
6) Confidence 0.50 Published 2005 Journal Clin Nutr Section Abstract Doc Link 15681097 Disease Relevance 1.32 Pain Relevance 0.10
Laboratory studies showed leukocytosis, hypernatremia, metabolic acidosis, elevated creatinine phosphokinase level, elevated transaminase levels, azotemia, hyperkalemia, hyperphosphatemia, hypocalcemia, and myoglobulinuria.
Positive_regulation (elevated) of transaminase associated with hypocalcemia, hyperkalemia, leukocytosis, hypernatremia, uremia and acid base imbalance
7) Confidence 0.50 Published 1999 Journal South. Med. J. Section Abstract Doc Link 10548178 Disease Relevance 1.38 Pain Relevance 0.09
Main exclusion criteria were: known familial hypercholesterolemia; secondary dyslipidemia of any cause; history of serious adverse effect (SAE) or hypersensitivity to other HMG-CoA reductase inhibitors; pregnancy, breast-feeding, and women of childbearing potential not using chemical or mechanical contraception or with a positive pregnancy test; malignancy; use of disallowed concomitant medications (antibiotics clarithromycin or erythromycin, antifungal treatment with fluconazole, ketoconazole, or itraconazole, lipid-lowering agents, cyclosporin); history of alcohol or drug dependence; active liver disease or hepatic dysfunction with elevations of alanine aminotransferase (ALT) or aspartate aminotransferase (AST) >1.5 times upper limit of normal (ULN); renal impairment as defined by serum creatinine >220 ?
Positive_regulation (elevations) of AST in upper associated with drug dependence, hypersensitivity, alcohol, addiction, liver disease, malignant neoplastic disease, fungal infection, hyperlipoproteinemia type ii and hepatotoxicity
8) Confidence 0.49 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663459 Disease Relevance 0.93 Pain Relevance 0.19
Anti-hepatotoxic enzymes include cytochrome P450 (CYP) super-family, or normalizing the levels of marker enzymes for the liver function test, such as glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT), acid phosphatase (ACP) and alkaline phosphatase (ALP) [90].
Positive_regulation (enzymes) of GOT in liver associated with glutamate
9) Confidence 0.49 Published 2010 Journal Chin Med Section Body Doc Link PMC2881933 Disease Relevance 0.73 Pain Relevance 0.28
Liver function tests showed a slight increase of alkaline phosphatase, GOT and GPT.
Positive_regulation (increase) of GOT in Liver
10) Confidence 0.48 Published 1984 Journal Gan No Rinsho Section Abstract Doc Link 6086980 Disease Relevance 0.62 Pain Relevance 0.09
In humans, only a small increase in incidence of elevated levels of serum glutamic oxaloacetic transaminase and serum glutamic pyruvic transaminase seems to be present and is not clearly different from that of the control groups.
Positive_regulation (increase) of transaminase
11) Confidence 0.47 Published 1987 Journal Am. J. Med. Section Abstract Doc Link 3318450 Disease Relevance 0.92 Pain Relevance 0.11
In humans, only a small increase in incidence of elevated levels of serum glutamic oxaloacetic transaminase and serum glutamic pyruvic transaminase seems to be present and is not clearly different from that of the control groups.
Positive_regulation (increase) of transaminase
12) Confidence 0.47 Published 1987 Journal Am. J. Med. Section Abstract Doc Link 3318450 Disease Relevance 0.92 Pain Relevance 0.11
There was decrease in the level of total protein and calcium and an increase of glutamic oxaloacetic transaminase (GOT), ammonia, sodium and potassium in serum.
Positive_regulation (increase) of glutamic oxaloacetic transaminase
13) Confidence 0.43 Published 1981 Journal Vet Hum Toxicol Section Abstract Doc Link 7336560 Disease Relevance 0.45 Pain Relevance 0.14
Transient elevations in transaminase and creatine phosphokinase levels commonly occur.
Positive_regulation (elevations) of transaminase associated with disorders of creatine metabolism
14) Confidence 0.41 Published 1990 Journal Drugs Section Abstract Doc Link 2226216 Disease Relevance 1.16 Pain Relevance 0.10
Mild leukopenia (3 patients), thrombocytopenia (3 patients), and elevated transaminase levels (8 patients) resolved with temporary drug discontinuation.
Positive_regulation (elevated) of transaminase associated with leukopenia and thrombocytopenia
15) Confidence 0.41 Published 1988 Journal Arthritis Rheum. Section Abstract Doc Link 3279962 Disease Relevance 1.28 Pain Relevance 0.41
Transaminase levels showed striking elevation, with a serum glutamic-oxaloacetic transaminase level of over 15,000 IU/liter, and decreased rapidly, consistent with a toxic insult.
Positive_regulation (elevation) of Transaminase
16) Confidence 0.40 Published 1983 Journal Am. J. Med. Section Abstract Doc Link 6824012 Disease Relevance 0.46 Pain Relevance 0.24
Transaminase levels showed striking elevation, with a serum glutamic-oxaloacetic transaminase level of over 15,000 IU/liter, and decreased rapidly, consistent with a toxic insult.
Positive_regulation (elevation) of transaminase
17) Confidence 0.40 Published 1983 Journal Am. J. Med. Section Abstract Doc Link 6824012 Disease Relevance 0.47 Pain Relevance 0.24
During a 90-min perfusion period, no elevation of either GOT, GPT, or LDH was found.
Neg (no) Positive_regulation (elevation) of GOT
18) Confidence 0.38 Published 2001 Journal Drug Metab. Dispos. Section Abstract Doc Link 11353741 Disease Relevance 0.39 Pain Relevance 0.26
None of the cardiogenic enzymes, such as creatine kinase, lactate dehydrogenase and glutamic oxaloacetic transaminase was elevated.
Positive_regulation (elevated) of glutamic oxaloacetic transaminase in cardiogenic
19) Confidence 0.38 Published 2004 Journal Nippon Jinzo Gakkai Shi Section Abstract Doc Link 16773801 Disease Relevance 1.27 Pain Relevance 0.21
These biomarkers are highly specific for acetaminophen-induced hepatic injury and correlate with hepatic transaminase elevation.
Positive_regulation (elevation) of transaminase associated with paracetamol and injury
20) Confidence 0.37 Published 2001 Journal J Clin Pharmacol Section Abstract Doc Link 11504272 Disease Relevance 0.50 Pain Relevance 0.84

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