INT4421

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Context Info
Confidence 0.44
First Reported 1975
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 12
Total Number 16
Disease Relevance 11.06
Pain Relevance 1.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
leukocyte 2
uterine 1
LAP (Homo sapiens)
Pain Link Frequency Relevance Heat
Dismenorea 7 99.90 Very High Very High Very High
cva 2 97.40 Very High Very High Very High
Pain 2 97.36 Very High Very High Very High
Chronic pancreatitis 2 96.08 Very High Very High Very High
isoflurane 3 95.60 Very High Very High Very High
alcohol 7 93.68 High High
anesthesia 2 79.28 Quite High
local anesthetic 1 76.40 Quite High
imagery 5 76.04 Quite High
ketamine 1 73.68 Quite High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 91 100.00 Very High Very High Very High
Reprotox - General 1 1 99.90 Very High Very High Very High
Uterine Hemorrhage 1 99.62 Very High Very High Very High
Cardiovascular Disease 495 99.44 Very High Very High Very High
Disease 39 99.42 Very High Very High Very High
Pruritus 1 98.84 Very High Very High Very High
Gallstones 4 98.80 Very High Very High Very High
Dysmenorrhea 6 98.66 Very High Very High Very High
Diabetes Mellitus 40 98.24 Very High Very High Very High
Decompression Sickness 2 97.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Whether increased LAP confers an excess risk of CVD or not has not directly been addressed.
Spec (Whether) Positive_regulation (increased) of LAP associated with cardiovascular disease
1) Confidence 0.44 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2949857 Disease Relevance 0.78 Pain Relevance 0
LAP increased risk of incident CVD among women.
Positive_regulation (increased) of LAP associated with cardiovascular disease
2) Confidence 0.41 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2949857 Disease Relevance 1.19 Pain Relevance 0.04
CVD incident rates per 1000 person increased in a stepwise fashion with increasing LAP quartile values in both men (from 6.9 to 17.0) and women (from 1.3 to 13.0), (P for trends <0.001).
Positive_regulation (increasing) of LAP associated with cardiovascular disease
3) Confidence 0.41 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2949857 Disease Relevance 1.68 Pain Relevance 0
As shown in Table 1 and 2, levels of common CVD risk factors significantly increases across LAP quartiles, except for family history of premature CVD among men and smoking among both sexes.
Positive_regulation (increases) of LAP associated with nicotine addiction and cardiovascular disease
4) Confidence 0.38 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2949857 Disease Relevance 1.64 Pain Relevance 0
Levels of common CVD risk factors significantly increased across LAP quartiles.
Positive_regulation (increased) of LAP associated with cardiovascular disease
5) Confidence 0.38 Published 2010 Journal Lipids Health Dis Section Abstract Doc Link PMC2949857 Disease Relevance 1.19 Pain Relevance 0
For Isoflurane, a slight reduction in cardiac output (CO) of 10% at a nearly constant LAP and a strong decrease of the peripheral resistance (Rperi) of 35% could be seen where Isoptin caused a significant reduction in CO of 40% at an increased LAP (+25%) and changes in Rperi of < 10%.
Positive_regulation (increased) of LAP associated with isoflurane
6) Confidence 0.23 Published 1996 Journal Artif Organs Section Abstract Doc Link 8817978 Disease Relevance 0.30 Pain Relevance 0.23
Since an increase in the right atrial pressure (RAP) above the left atrial pressure (LAP) may then lead to paradoxical air embolism, the efficacy of pneumatic antishock garments (PASGs) and ventilation with positive end-expiratory pressure (PEEP) in preventing increases in the RAP above the LAP was investigated during neurosurgical procedures.
Positive_regulation (increases) of LAP associated with decompression sickness and cva
7) Confidence 0.15 Published 1992 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 15815459 Disease Relevance 0.10 Pain Relevance 0.13
Volume expansion caused LAP to increase in all groups (SAD 13.9 +/- 6.3; control VB 11.6 +/- 1.8, control 9.3 +/- 0.89, SAD VB 7.66 +/- 3.46).
Positive_regulation (increase) of LAP
8) Confidence 0.10 Published 1988 Journal Am. J. Physiol. Section Abstract Doc Link 3381911 Disease Relevance 0.13 Pain Relevance 0.08
The leukocyte alkaline phosphatase (LAP) score did not increase during crisis; the scores were in the low-normal range during crisis and noncrisis periods.
Neg (not) Positive_regulation (increase) of LAP in leukocyte
9) Confidence 0.09 Published 1980 Journal Am. J. Hematol. Section Abstract Doc Link 7011001 Disease Relevance 0.26 Pain Relevance 0.10
The splenocytes of untreated mice showed low levels of c/ebp Beta proteins, whereas the levels of both the LAP and LIP isoform of c/ebp Beta were significantly increased 24 h after treatment with LPS (Figure 4C), in accordance with a previous report (14).
Positive_regulation (increased) of LAP
10) Confidence 0.04 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2761263 Disease Relevance 0.06 Pain Relevance 0.03
The c/ebp Beta transcript encodes three isoforms, designated as LAP*, LAP and LIP, that are generated by differential translational initiation (Figure 2A).
Positive_regulation (generated) of LAP
11) Confidence 0.04 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2761263 Disease Relevance 0 Pain Relevance 0
Western blot analysis using the C-terminal specific c/ebp Beta antibody showed that the levels of both the LAP and LIP isoforms of c/ebp Beta were increased after treatment with LPS, in accordance with a previous report (14) (Figure 3).
Positive_regulation (increased) of LAP
12) Confidence 0.04 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2761263 Disease Relevance 0.25 Pain Relevance 0
It is suggested that the diagnosis of adenomyosis must be considered in cases of uterine bleeding, dysmenorrhea and increased CAP and LAP values discovered in multiparous women of around 50 years of age, even when the bimanual examination does not reveal any other pathologic condition.
Positive_regulation (increased) of LAP in uterine associated with uterine hemorrhage and dismenorea
13) Confidence 0.04 Published 1981 Journal Int Surg Section Abstract Doc Link 7345047 Disease Relevance 0.66 Pain Relevance 0.56
The patients showed higher levels of timol test, cholesterol, LDL-cholesterol, coefficient LDL/HDL-cholesterol, beta-lipoproteins, total lipids, gamma-GTP, ASAT and lower levels of leucocytes, bilirubin, SMC, alkaline phosphatase and LAP than the other patients with cholestasis.
Positive_regulation (levels) of LAP in leucocytes associated with gallstones and disorder of lipid metabolism
14) Confidence 0.04 Published 1989 Journal Vutr Boles Section Abstract Doc Link 2633477 Disease Relevance 1.42 Pain Relevance 0.39
Each LPG disease differed from all others by elevations of both leucine-aminopeptidase (LAP) and alkaline phosphatase (AP) levels.
Positive_regulation (elevations) of LAP associated with disease
15) Confidence 0.04 Published 1975 Journal South. Med. J. Section Abstract Doc Link 1162426 Disease Relevance 0.64 Pain Relevance 0.08
LAP level was low or normal and serum glutamic oxaloacetic transaminase (SGOT) and AP levels were elevated in 43 non-LPG diseases.
Positive_regulation (elevated) of LAP associated with disease
16) Confidence 0.03 Published 1975 Journal South. Med. J. Section Abstract Doc Link 1162426 Disease Relevance 0.75 Pain Relevance 0.10

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