INT4422

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Context Info
Confidence 0.50
First Reported 1975
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 30
Total Number 31
Disease Relevance 18.56
Pain Relevance 6.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Alb) extracellular space (Alb) extracellular region (Alb)
enzyme binding (Alb) DNA binding (Alb) protein complex (Alb)
Anatomy Link Frequency
Hepatocyte 6
plasma 4
Erythrocyte 2
knee joints 2
urine 2
Alb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
amygdala 58 100.00 Very High Very High Very High
lidocaine 1 100.00 Very High Very High Very High
cINOD 15 99.60 Very High Very High Very High
c fibre 3 99.60 Very High Very High Very High
Arthritis 61 98.90 Very High Very High Very High
Crohn's disease 7 96.40 Very High Very High Very High
long-term potentiation 3 95.20 Very High Very High Very High
Hippocampus 4 93.08 High High
antagonist 14 89.80 High High
Inflammation 78 89.60 High High
Disease Link Frequency Relevance Heat
Cancer 34 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 8 100.00 Very High Very High Very High
Stress 175 99.98 Very High Very High Very High
Proteinuria 18 99.60 Very High Very High Very High
INFLAMMATION 79 99.32 Very High Very High Very High
Schistosomiasis Haematobia 3 98.92 Very High Very High Very High
Experimental Arthritis 7 98.90 Very High Very High Very High
Non-small-cell Lung Cancer 44 98.66 Very High Very High Very High
Disease 49 98.16 Very High Very High Very High
Albuminuria 7 98.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increase in cerebrovascular permeability was temporary, however, although Evans blue albumin extravasion remained slightly elevated 3 h after infusion, it was normal 6 h after infusion.
Positive_regulation (elevated) of Gene_expression (extravasion) of albumin
1) Confidence 0.50 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 7637893 Disease Relevance 0 Pain Relevance 0.08
The objectives of this study were to determine whether 1) the leukocyte-endothelial cell adhesion observed in venules exposed to nonsteroidal anti-inflammatory drugs (NSAIDs) is accompanied by enhanced albumin extravasation, and 2) leukocytes mediate this endothelial cell barrier dysfunction.
Spec (whether) Positive_regulation (enhanced) of Gene_expression (extravasation) of albumin in venules associated with inflammation, cinod and adhesions
2) Confidence 0.50 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8779980 Disease Relevance 0.42 Pain Relevance 0.48
Cells were spun down onto 5% bovine serum albumin (BSA) to remove debris, then resuspended in Neurobasal medium with 10% horse serum, and passed through a 40 ?
Positive_regulation (bovine) of Gene_expression (spun) of serum albumin
3) Confidence 0.49 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1420316 Disease Relevance 0 Pain Relevance 0.09
Erythrocyte sedimentation rate or serum albumin improved in eight of 13 patients.
Positive_regulation (improved) of Gene_expression (improved) of albumin in Erythrocyte
4) Confidence 0.43 Published 1989 Journal Dig. Dis. Sci. Section Abstract Doc Link 2766906 Disease Relevance 0.80 Pain Relevance 0.35
It has been previously demonstrated that patients with advanced cancer have an important energy expenditure caused by increased tumor metabolism [41] and specifically in patients with NSCLC, also by means of chronic airway limitation [42] Therefore, serum albumin levels can be modified by tumor activity via increased FCR, but also by decreasing albumin synthesis, given that the majority of the time, patients with NSCLC display decreased appetite [43] and diminish their food intake [44].
Positive_regulation (increased) of Gene_expression (synthesis) of albumin associated with non-small-cell lung cancer and cancer
5) Confidence 0.40 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2843671 Disease Relevance 1.18 Pain Relevance 0.11
It has been previously demonstrated that patients with advanced cancer have an important energy expenditure caused by increased tumor metabolism [41] and specifically in patients with NSCLC, also by means of chronic airway limitation [42] Therefore, serum albumin levels can be modified by tumor activity via increased FCR, but also by decreasing albumin synthesis, given that the majority of the time, patients with NSCLC display decreased appetite [43] and diminish their food intake [44].
Positive_regulation (increased) of Gene_expression (synthesis) of albumin associated with non-small-cell lung cancer and cancer
6) Confidence 0.40 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2843671 Disease Relevance 1.17 Pain Relevance 0.11
However, albumin synthesis increases when ammonia levels are higher.
Positive_regulation (increases) of Gene_expression (synthesis) of albumin
7) Confidence 0.39 Published 2008 Journal Comp Hepatol Section Body Doc Link PMC2262055 Disease Relevance 0.71 Pain Relevance 0.19
The distribution of polymodal C-fibers was tested through stimulation-induced extravasation of Evans blue albumin (EBA).
Positive_regulation (stimulation-induced) of Gene_expression (extravasation) of Evans blue albumin associated with c fibre
8) Confidence 0.39 Published 1994 Journal Exp. Neurol. Section Abstract Doc Link 8070516 Disease Relevance 0.22 Pain Relevance 0.24
METHODS: AIA was induced by injecting methylated bovine serum albumin (mBSA) into the knee joints of previously immunized rats that were treated orally with the NSAID piroxicam or with saline.
Positive_regulation (induced) of Gene_expression (injecting) of serum albumin in knee joints
9) Confidence 0.39 Published 2008 Journal Scand. J. Rheumatol. Section Body Doc Link 19005999 Disease Relevance 0.29 Pain Relevance 0
A significant finding of our study was the three-six fold increase in albumin production in rLSEC-PEM-Hepatocyte cultures.
Positive_regulation (increase) of Gene_expression (production) of albumin in Hepatocyte
10) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2980491 Disease Relevance 0.17 Pain Relevance 0
Albumin production increased three to six fold in the rLSEC-PEM-Hepatocyte cultures.
Positive_regulation (increased) of Gene_expression (production) of Albumin in Hepatocyte
11) Confidence 0.39 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2980491 Disease Relevance 0 Pain Relevance 0.04
When compared to normal animals, AA rats had significantly (P less than or equal to 0.01) increased: (1) splenic LAF activity (100% increase), (2) plasma Fn (58%), and (3) CRP (122%), as well as abnormally reduced levels of: (1) plasma albumin (53% reduction), and (2) iron (54%).
Positive_regulation (increased) of Gene_expression (levels) of plasma albumin in plasma associated with arthritis
12) Confidence 0.37 Published 1988 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 3143680 Disease Relevance 1.23 Pain Relevance 0.49
On the other hand, acute administration of methamphetamine (40 mg/kg, i.p.) in mice resulted in marked extravasation of endogenous serum protein as seen with increased expression of albumin immunohistochemistry.
Positive_regulation (increased) of Gene_expression (expression) of albumin
13) Confidence 0.36 Published 2006 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 17105918 Disease Relevance 0.55 Pain Relevance 0.66
Both albumin production and lidocaine metabolism (P-450 activity) were significantly increased in the high fluorescence group compared to the low fluorescence group.
Positive_regulation (increased) of Gene_expression (production) of albumin associated with lidocaine
14) Confidence 0.31 Published 1993 Journal Biotech Histochem Section Abstract Doc Link 7680583 Disease Relevance 0 Pain Relevance 0.10
In contrast, all the 3D hepatic cultures exhibited a significant 3–6 fold elevation in albumin production.
Positive_regulation (elevation) of Gene_expression (production) of albumin
15) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2980491 Disease Relevance 0 Pain Relevance 0
[Relationship between prolonged life span and changes of serum IAP and albumin induced by the therapy of lentinan plus tegafur in inoperable and recurrent gastric cancer].
Positive_regulation (induced) of Gene_expression (changes) of albumin associated with stomach cancer
16) Confidence 0.26 Published 1992 Journal Nippon Geka Gakkai Zasshi Section Title Doc Link 1435705 Disease Relevance 0.27 Pain Relevance 0.08
This difference disappeared, however, when serum zinc concentrations were corrected for albumin levels, which were lower in all the patient groups.
Positive_regulation (lower) of Gene_expression (levels) of albumin
17) Confidence 0.26 Published 1989 Journal J Trace Elem Electrolytes Health Dis Section Abstract Doc Link 2535348 Disease Relevance 0.75 Pain Relevance 0.33
IDPN improves serum albumin and body weight.
Positive_regulation (improves) of Gene_expression (improves) of albumin in body
18) Confidence 0.23 Published 2010 Journal J Ren Nutr Section Body Doc Link 20303785 Disease Relevance 0 Pain Relevance 0
Predator stress induced changes in ALB and amygdala neural transmission are
Positive_regulation (induced) of in amygdala Gene_expression (transmission) of ALB in neural associated with stress and amygdala
19) Confidence 0.21 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2664642 Disease Relevance 1.37 Pain Relevance 0.92
Urinary schistosomiasis on Zanzibar: application of two novel assays for the detection of excreted albumin and haemoglobin in urine.
Positive_regulation (excreted) of Gene_expression (detection) of albumin in urine associated with schistosomiasis haematobia
20) Confidence 0.19 Published 2005 Journal J. Helminthol. Section Title Doc Link 16153313 Disease Relevance 0.53 Pain Relevance 0.05

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