INT44237

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Context Info
Confidence 0.07
First Reported 1983
Last Reported 1997
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 0.94
Pain Relevance 2.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (PLEKHM1)
Anatomy Link Frequency
platelet 6
blood 2
PLEKHM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 17 99.36 Very High Very High Very High
aspirin 11 97.38 Very High Very High Very High
diclofenac 6 96.24 Very High Very High Very High
Inflammation 2 77.92 Quite High
local anesthetic 2 76.28 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 9 97.82 Very High Very High Very High
Coagulation Disorder 3 86.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Addition of acetylsalicylic acid (IC50 = 2.8 microM) or other nonsteroidal antiinflammatory drugs (NSAIDs) 15 min or 4.5h prior to 30 min stimulation with ionophore results in concentration dependent inhibition of TxB2 production.
Negative_regulation (inhibition) of Gene_expression (production) of TxB2 associated with aspirin, inflammation and cinod
1) Confidence 0.07 Published 1996 Journal Inflamm. Res. Section Abstract Doc Link 8737748 Disease Relevance 0.10 Pain Relevance 0.25
In a 5h assay, NSAIDs added at 0 h were compared for inhibition of TxB2 production stimulated by addition of ionophore A23187 at 4.5h (PGHS-1), or by addition of LPS at 0 h (PGHS-2).
Negative_regulation (inhibition) of Gene_expression (production) of TxB2 associated with cinod
2) Confidence 0.07 Published 1996 Journal Inflamm. Res. Section Abstract Doc Link 8737748 Disease Relevance 0.07 Pain Relevance 0.39
On the other hand, flunixin was clearly a more potent inhibitor of TxB2 production and adrenaline-induced platelet aggregation than tolfenamic acid, the IC50 values in TxB2 production being 0.28 +/- 0.02 microM and 2.6 +/- 0.3 microM for flunixin and tolfenamic acid, respectively.
Negative_regulation (inhibitor) of Gene_expression (production) of TxB2 in platelet
3) Confidence 0.07 Published 1993 Journal Inflammation Section Abstract Doc Link 8406686 Disease Relevance 0.24 Pain Relevance 0.08
The concentrations of the drugs needed for 50% inhibition of TxB2 generation were 19.0 mumol/l for acetyl-salicylic acid, 0.09 mumol/l for indomethacin, 0.06 mumol/l for diclofenac sodium and 4.2 mumol/l for naproxen sodium.
Negative_regulation (inhibition) of Gene_expression (generation) of TxB2 associated with diclofenac
4) Confidence 0.05 Published 1983 Journal Prostaglandins Section Abstract Doc Link 6405453 Disease Relevance 0.23 Pain Relevance 0.27
Using a 5h incubation with 10 micrograms/ml LPS, aspirin (10 microM added at 0 h), which is rapidly metabolized to salicylic acid, had no effect on 10 micrograms/ml LPS-induced TxB2, but inhibited TxB2 production by ionophore A23187 added at 4.5h through acetylation of pre-existing PGHS-1.
Negative_regulation (inhibited) of Gene_expression (production) of TxB2 associated with aspirin
5) Confidence 0.05 Published 1996 Journal Inflamm. Res. Section Abstract Doc Link 8737748 Disease Relevance 0.08 Pain Relevance 0.38
In conclusion, our results demonstrate for the first time that PABA, a substance occurring in nature, inhibits endogenous TxB2 synthesis in human platelets and might thus exert profound effects on platelet AA metabolism.
Negative_regulation (inhibits) of Gene_expression (synthesis) of TxB2 in platelet
6) Confidence 0.04 Published 1997 Journal Thromb. Res. Section Abstract Doc Link 9175234 Disease Relevance 0.06 Pain Relevance 0.16
When platelets were incubated with [1-14C]AA, in the presence of PABA, the production of [1-14C]TxB2 was only slightly inhibited, according to analysis by high pressure liquid chromatography.
Negative_regulation (inhibited) of Gene_expression (production) of TxB2 in platelets
7) Confidence 0.03 Published 1997 Journal Thromb. Res. Section Abstract Doc Link 9175234 Disease Relevance 0.08 Pain Relevance 0.19
In vitro enzyme results were supported by a human whole blood assay where etodolac also demonstrated a 10-fold selectivity for inhibition of PGHS-2 mediated TxB2 production.
Negative_regulation (inhibition) of Gene_expression (production) of TxB2 in blood
8) Confidence 0.01 Published 1995 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8566109 Disease Relevance 0.08 Pain Relevance 0.35

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