INT44249

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Context Info
Confidence 0.51
First Reported 1982
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 1.99
Pain Relevance 4.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ELK3) mitochondrion (ELK3) nucleolus (ELK3)
nucleus (ELK3)
Anatomy Link Frequency
vertex 1
ELK3 (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 8 99.78 Very High Very High Very High
action potential duration 20 99.36 Very High Very High Very High
ketamine 22 99.20 Very High Very High Very High
aspirin 3 99.16 Very High Very High Very High
nMDA receptor 14 98.82 Very High Very High Very High
Acupuncture 2 98.64 Very High Very High Very High
Pain 16 98.52 Very High Very High Very High
adenocard 50 98.50 Very High Very High Very High
Analgesic 5 97.76 Very High Very High Very High
analgesia 8 97.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Sleep Disorders 104 99.72 Very High Very High Very High
Arthritis 83 93.60 High High
Cognitive Disorder 21 89.36 High High
Pain 11 87.60 High High
Schizophrenia 2 80.28 Quite High
Hallucination 3 79.84 Quite High
Arrhythmias 2 Under Development 3 72.48 Quite High
Disease 10 71.12 Quite High
Heart Rate Under Development 6 60.24 Quite High
Cardiovascular Disorder Under Development 4 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Naloxone injection reversed both ERP and SPR changes, but surprisingly, a reversal of narcotic analgesia equal to that of 0.4 mg naloxone was seen with saline injection.
Negative_regulation (reversed) of ERP associated with narcan and analgesia
1) Confidence 0.51 Published 1983 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 6407047 Disease Relevance 0.16 Pain Relevance 0.97
Previous work by the authors demonstrated that inhalation of nitrous oxide 33 per cent in oxygen, iv injection of 0.1 mg fentanyl, oral administration of 975 mg aspirin, and electrical acupunctural stimulation all reduced ERP amplitudes obtained a vertex during painful tooth pulp stimulation.
Negative_regulation (reduced) of ERP in vertex associated with pain and aspirin
2) Confidence 0.37 Published 1982 Journal Anesthesiology Section Abstract Doc Link 7072999 Disease Relevance 0.29 Pain Relevance 0.61
Fentanyl reduced both ERP waveform amplitudes and SPR as have previously studied analgesic agents, such as nitrous oxide, acupuncture, and aspirin.
Negative_regulation (reduced) of ERP associated with aspirin, analgesic and acupuncture
3) Confidence 0.37 Published 1983 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 6407047 Disease Relevance 0.17 Pain Relevance 0.95
Appropriate patients are then referred to an ERP, most often a nurse practitioner or clinical nurse specialist, and in some cases, a physiotherapist or occupational therapist, for ongoing monitoring and management over time.
Negative_regulation (referred) of ERP
4) Confidence 0.37 Published 2008 Journal BMC Health Serv Res Section Body Doc Link PMC2491608 Disease Relevance 0.39 Pain Relevance 0.18
Ketamine did not significantly alter PPI or the reduction of the P50 ERP.
Negative_regulation (reduction) of ERP associated with ketamine
5) Confidence 0.26 Published 1998 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 9683005 Disease Relevance 0.22 Pain Relevance 0.65
Recently, much interest has been given to the role of glutamatergic N-methyl-D-aspartate receptors (NMDA) in sensory gating, such as prepulse inhibition (PPI) and reduction of the P50 evoked response potential (ERP).
Negative_regulation (reduction) of ERP associated with nmda receptor
6) Confidence 0.23 Published 1998 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 9683005 Disease Relevance 0.08 Pain Relevance 0.35
In sum, the effects of increased AD and decreased ACh levels match the macroscopic effects of SD, such as the reduced ERP components and changes in EEG rhythms.
Negative_regulation (reduced) of ERP associated with adenocard and sleep disorders
7) Confidence 0.09 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2778638 Disease Relevance 0.61 Pain Relevance 0.44
Class I drugs have been traditionally subdivided into three categories—Ia, Ib and Ic—according to their kinetics of action (intermediate, fast and slow, respectively; Trevor & Katzung 2003) and also their different effects on the effective refractory period (ERP): class Ib drugs markedly depressed ERP (and shortened APD), whereas Ic drugs had minor effects on ERP and the Ia subgroup moderately prolonged ERP (and APD; Campbell 1983).
Negative_regulation (depressed) of ERP associated with action potential duration
8) Confidence 0.06 Published 2010 Journal Philosophical transactions. Series A, Mathematical, physical, and engineering sciences Section Body Doc Link PMC2944395 Disease Relevance 0.07 Pain Relevance 0.30

General Comments

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