INT44254

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Context Info
Confidence 0.43
First Reported 1983
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 7.06
Pain Relevance 3.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ALOX5) nuclear envelope (ALOX5) small molecule metabolic process (ALOX5)
oxidoreductase activity (ALOX5) nucleus (ALOX5) cytoplasm (ALOX5)
Anatomy Link Frequency
osteoblasts 4
chondrocytes 2
ALOX5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 823 100.00 Very High Very High Very High
cINOD 76 100.00 Very High Very High Very High
aspirin 86 99.42 Very High Very High Very High
COX-2 inhibitor 28 92.60 High High
Inflammatory response 12 78.64 Quite High
Inflammation 85 74.40 Quite High
Pain 17 58.64 Quite High
Inflammatory mediators 2 44.24 Quite Low
Arthritis 4 37.04 Quite Low
Angina 1 14.88 Low Low
Disease Link Frequency Relevance Heat
Osteoarthritis 838 100.00 Very High Very High Very High
INFLAMMATION 123 100.00 Very High Very High Very High
Occupational Lung Diseases 2 99.84 Very High Very High Very High
Asthma 133 96.36 Very High Very High Very High
Bronchospasm 6 96.08 Very High Very High Very High
Eosinophilia 1 89.60 High High
Osteophyte 16 88.16 High High
Hypersensitivity 5 85.20 High High
Osteoporosis 35 76.16 Quite High
Nasal Polyps 16 65.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
bp from rs2115819, while the ALOX5 SNP rs11239524 is ~11?
Regulation (~11) of Gene_expression (rs11239524) of ALOX5
1) Confidence 0.43 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2878676 Disease Relevance 0 Pain Relevance 0
The effect of prostaglandins, nonsteroidal anti-inflammatory drugs, lipoxygenase products of arachidonic acid, and other mucus-stimulating and mucus-inhibiting agents was studied.
Regulation (effect) of Gene_expression (products) of lipoxygenase associated with inflammation and cinod
2) Confidence 0.39 Published 1983 Journal J Asthma Section Abstract Doc Link 6408056 Disease Relevance 0.30 Pain Relevance 0.27
As the lipoxygenase pathway is the only operant metabolic system available for arachidonic acid in the presence of aspirin and non-steroidal anti-inflammatory drugs--and as the nonsteroidal anti-inflammatory drugs themselves stimulate mucus production--it is possible that the mechanism responsible for mucus release in aspirin-sensitive asthmatics is the formation of these lipoxygenase products.
Regulation (formation) of Gene_expression (products) of lipoxygenase associated with aspirin, inflammation, cinod and occupational lung diseases
3) Confidence 0.39 Published 1983 Journal J Asthma Section Abstract Doc Link 6408056 Disease Relevance 0.52 Pain Relevance 0.40
To determine whether augmented LTB4 production induced by HNE is related to 5-LOX and FLAP synthesis, we further examined the effect of HNE on their mRNA expression.
Spec (whether) Regulation (related) of Gene_expression (synthesis) of 5-LOX
4) Confidence 0.16 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.36 Pain Relevance 0.18
Several investigations have shown that 5-LOX and FLAP expression is regulated by PGE2 [28,42].
Regulation (regulated) of Gene_expression (expression) of 5-LOX
5) Confidence 0.16 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.08 Pain Relevance 0.04
The present study demonstrated that the induction of LTB4 production in response to NSAIDs or NS-398 in OA osteoblasts involved no major modification of 5-LO expression, in contrast to the situation observed in OA chondrocytes [56].
Regulation (modification) of Gene_expression (expression) of 5-LO in chondrocytes associated with cinod and osteoarthritis
6) Confidence 0.07 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.97 Pain Relevance 0.80
Again, this would suggest that FLAP is the key enzyme that controls the production of LTs in OA osteoblasts, rather than 5-LO, which showed little variation of expression regardless of treatment.
Regulation (controls) of Gene_expression (production) of 5-LO in osteoblasts associated with osteoarthritis
7) Confidence 0.05 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.53 Pain Relevance 0.23
We studied whether the expression of 5-lipoxygenase (5-LO) or 5-LO-activating protein (FLAP) is responsible for the shunt from prostaglandins to leukotrienes.
Regulation (responsible) of Gene_expression (expression) of 5-LO
8) Confidence 0.04 Published 2006 Journal Arthritis Res Ther Section Abstract Doc Link PMC1794527 Disease Relevance 0.85 Pain Relevance 0.34
Regulation of expression of 5-LO and FLAP
Regulation (Regulation) of Gene_expression (expression) of 5-LO
9) Confidence 0.03 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.58 Pain Relevance 0.29
We measured the expression of the two key enzymes involved in LT production, 5-LO and FLAP (Figure 2).
Regulation (involved) of Gene_expression (expression) of 5-LO
10) Confidence 0.03 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.65 Pain Relevance 0.33
This effect was not due to any significant modification of 5-LO expression in these cells (not shown).
Regulation (modification) of Gene_expression (expression) of 5-LO
11) Confidence 0.03 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.58 Pain Relevance 0.29
In contrast, under similar experimental conditions with PGE2 or NS-398, 5-LO expression did not vary significantly in either normal or OA osteoblasts (not shown).
Regulation (vary) of Gene_expression (expression) of 5-LO in osteoblasts associated with osteoarthritis
12) Confidence 0.03 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1794527 Disease Relevance 0.68 Pain Relevance 0.38
Expression of 5-LO is modulated by a genetic variation in the transcription factor binding motif of the 5-LO gene.
Regulation (modulated) of Gene_expression (Expression) of 5-LO
13) Confidence 0.00 Published 2008 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2868885 Disease Relevance 0.96 Pain Relevance 0.11

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