INT44274

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Context Info
Confidence 0.33
First Reported 1983
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.28
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ALOX5) nuclear envelope (ALOX5) small molecule metabolic process (ALOX5)
oxidoreductase activity (ALOX5) nucleus (ALOX5) cytoplasm (ALOX5)
Anatomy Link Frequency
chondrocytes 2
platelet 2
ALOX5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 44 99.60 Very High Very High Very High
aspirin 2 99.60 Very High Very High Very High
cINOD 3 81.96 Quite High
cytokine 3 67.92 Quite High
Inflammation 17 34.32 Quite Low
alcohol 1 15.76 Low Low
metalloproteinase 7 5.00 Very Low Very Low Very Low
licofelone 3 5.00 Very Low Very Low Very Low
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 48 99.60 Very High Very High Very High
INFLAMMATION 23 81.76 Quite High
Disease 3 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Osteophyte 1 5.00 Very Low Very Low Very Low
Apoptosis 1 5.00 Very Low Very Low Very Low
Necrosis 1 5.00 Very Low Very Low Very Low
Adhesions 1 5.00 Very Low Very Low Very Low
Pathologic Processes 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Salicylate fails to prevent the inhibitory effect of 5,8,11,14-eicosatetraynoic acid on human platelet cyclo-oxygenase and lipoxygenase activities.
Negative_regulation (prevent) of Regulation (effect) of lipoxygenase in platelet associated with aspirin
1) Confidence 0.33 Published 1983 Journal Biochim. Biophys. Acta Section Title Doc Link 6411131 Disease Relevance 0.08 Pain Relevance 0.18
Thereafter, we explored 5-LOX and FLAP regulation in human OA chondrocytes by HNE, examined the relative involvement of these two proteins in LTB4 production, and studied the factors that might be responsible for enhanced LTB4 production in these cells incubated for long periods.
Negative_regulation (explored) of Spec (examined) Regulation (regulation) of 5-LOX in chondrocytes associated with osteoarthritis
2) Confidence 0.13 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.19 Pain Relevance 0.13

General Comments

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