INT44288

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Context Info
Confidence 0.45
First Reported 1983
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 0.54
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Ugt1a1) enzyme binding (Ugt1a1)
Anatomy Link Frequency
CAR 1
liver 1
Ugt1a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 18 100.00 Very High Very High Very High
Opioid 1 92.76 High High
agonist 1 87.52 High High
Morphine 10 50.00 Quite Low
vincristine 2 50.00 Quite Low
bradykinin 2 50.00 Quite Low
antagonist 2 50.00 Quite Low
Hyperalgesia 1 50.00 Quite Low
diabetic neuropathy 1 50.00 Quite Low
Pain 1 10.00 Low Low
Disease Link Frequency Relevance Heat
Toxicity 4 96.48 Very High Very High Very High
Necrosis 1 81.28 Quite High
Neuropathic Pain 1 65.60 Quite High
Diabetes Mellitus 1 62.88 Quite High
Cancer 2 50.00 Quite Low
Hyperalgesia 1 50.00 Quite Low
Diabetic Neuropathy 1 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present results suggest that heroin and naltrexone can reduce estradiol glucuronidation via a specific interaction with UGT1A1 isoform.
UGT1A1 Binding (interaction) of
1) Confidence 0.45 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18639530 Disease Relevance 0 Pain Relevance 0.09
Moreover, the contribution of UGT1A1 to the formation of M3G appears to be of minor biological significance, at least in a UGT2B7 background.


UGT1A1 Binding (contribution) of
2) Confidence 0.33 Published 2002 Journal Eur. J. Clin. Pharmacol. Section Body Doc Link 12185559 Disease Relevance 0 Pain Relevance 0
Taken together, these results indicate that nutritional status may gender-specifically influence the expression and activation of CAR and PPARalpha in liver cell nuclei, and this effect appears to be associated with alterations in UGT1A1 and UGT1A6 expression.
UGT1A1 Binding (alterations) of in CAR
3) Confidence 0.32 Published 2008 Journal Drug Metab. Dispos. Section Abstract Doc Link 17967931 Disease Relevance 0 Pain Relevance 0.26
The results demonstrate that paracetamol is conjugated by HlugP1 and its rat orthologue UGT1A1 with higher affinity than by HlugP4 and other UGTs.
UGT1A1 Binding (conjugated) of associated with paracetamol
4) Confidence 0.30 Published 1993 Journal Biochem. Pharmacol. Section Abstract Doc Link 8494539 Disease Relevance 0 Pain Relevance 0.55
It shows higher affinity for HlugP1 and rat UGT1A1 (apparent Km values of 2 and 3 mM, respectively) than for HlugP4 (Km = 50 mM) and other UGTs present in liver microsomes (Km values of > 12 mM).
UGT1A1 Binding (affinity) of in liver
5) Confidence 0.26 Published 1993 Journal Biochem. Pharmacol. Section Abstract Doc Link 8494539 Disease Relevance 0 Pain Relevance 0.48
The hepatotoxicities of three compounds which bind to glutathione S-transferase; iodipamide, acetaminophen, and aflatoxin B1, are decreased by selenium deficiency.
B1 Binding (bind) of associated with paracetamol
6) Confidence 0.15 Published 1983 Journal Fundam Appl Toxicol Section Abstract Doc Link 6414870 Disease Relevance 0.42 Pain Relevance 0.10
CONCLUSIONS: Results of these studies suggest that B1 and B2 receptors are engaged in transmission of nociceptive stimuli in both diabetic and toxic neuropathy.
B1 Binding (engaged) of
7) Confidence 0.12 Published 2009 Journal Neuro Endocrinol. Lett. Section Body Doc Link 19300402 Disease Relevance 0.13 Pain Relevance 0

General Comments

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