INT44293

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Context Info
Confidence 0.24
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.88
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TP63) nucleoplasm (TP63) anatomical structure formation involved in morphogenesis (TP63)
Golgi apparatus (TP63) nucleolus (TP63) nucleus (TP63)
Anatomy Link Frequency
immune system 1
uterine 1
TP63 (Homo sapiens)
TP63 - P1308L (1)
Pain Link Frequency Relevance Heat
cytokine 40 99.48 Very High Very High Very High
Inflammation 72 93.20 High High
psoriasis 110 90.52 High High
Pain 26 86.40 High High
sodium channel 9 79.60 Quite High
methotrexate 12 54.96 Quite High
Arthritis 26 40.64 Quite Low
Multiple sclerosis 22 36.48 Quite Low
tetrodotoxin 11 30.48 Quite Low
Etanercept 34 12.24 Low Low
Disease Link Frequency Relevance Heat
Leiomyosarcoma 59 100.00 Very High Very High Very High
Canker Sores 6 100.00 Very High Very High Very High
INFLAMMATION 72 93.20 High High
Psoriasis 136 90.52 High High
Ulcers 1 87.64 High High
Adenocarcinoma 4 86.96 High High
Pain 25 86.40 High High
Uterine Fibroids 3 80.48 Quite High
Arthritis 2 76.76 Quite High
Disease 73 67.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
OBJECTIVES: To establish normal values of CuSP, to compare these values to those in the literature and to discuss the yield of the CuSP in pathological conditions.
Regulation (values) of CuSP
1) Confidence 0.24 Published 2006 Journal Medicina (Kaunas) Section Body Doc Link 16687902 Disease Relevance 0 Pain Relevance 0
responsiveness in the human uterine LMS cell line was attributable to the inadequate kinase activity of JAK1 due to a G781E mutation in the ATP-binding region (Hayashi et al. 2006).


Regulation (responsiveness) of LMS in uterine associated with leiomyosarcoma
2) Confidence 0.12 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733082 Disease Relevance 0.79 Pain Relevance 0
Ustekinumab is a monoclonal antibody belonging to a newly developed class of biological, anti-cytokine medications that notably targets the p40 subunit of both IL-12 and -23, both naturally occurring proteins that are important in regulating the immune system and are understood to play a role in immune-mediated inflammatory disorders.
Regulation (targets) of p40 in immune system associated with inflammation and cytokine
3) Confidence 0.02 Published 2010 Journal Therapeutics and Clinical Risk Management Section Abstract Doc Link PMC2857612 Disease Relevance 0.69 Pain Relevance 0.38
The intensities of WT, P1308L, V1298F channels were normalized with the intensities of ?
Regulation (intensities) of P1308L (P1308L)
4) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2876140 Disease Relevance 0 Pain Relevance 0.04
IL-12 and IL-23 both share a common p40 subunit which is the target for the human monoclonal antibody ustekinumab.
Regulation (target) of p40
5) Confidence 0.02 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 0.65 Pain Relevance 0.25
Effect of zendium toothpaste on recurrent aphthous stomatitis.
Regulation (Effect) of stomatitis associated with canker sores
6) Confidence 0.00 Published 1983 Journal Scand J Dent Res Section Title Doc Link 6415805 Disease Relevance 0.76 Pain Relevance 0.09

General Comments

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