INT443

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Context Info
Confidence 0.81
First Reported 1975
Last Reported 2010
Negated 10
Speculated 15
Reported most in Abstract
Documents 1020
Total Number 1039
Disease Relevance 284.52
Pain Relevance 443.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (POMC) cell-cell signaling (POMC) cytoplasm (POMC)
extracellular space (POMC) generation of precursor metabolites and energy (POMC) signal transduction (POMC)
Anatomy Link Frequency
pituitary 106
plasma 32
melanocyte 27
anterior pituitary 21
corticotroph 17
POMC (Homo sapiens)
POMC - A2M (1)
Pain Link Frequency Relevance Heat
Enkephalin 2175 100.00 Very High Very High Very High
Inflammation 2058 100.00 Very High Very High Very High
Opioid 1439 100.00 Very High Very High Very High
cytokine 1017 100.00 Very High Very High Very High
narcan 949 100.00 Very High Very High Very High
Neuropeptide 779 100.00 Very High Very High Very High
Somatostatin 460 100.00 Very High Very High Very High
Dopamine 401 100.00 Very High Very High Very High
substance P 387 100.00 Very High Very High Very High
opiate 377 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 3105 100.00 Very High Very High Very High
Cancer 1849 100.00 Very High Very High Very High
Adenoma 625 100.00 Very High Very High Very High
Pituitary Cancer 609 100.00 Very High Very High Very High
Prolactinoma 314 100.00 Very High Very High Very High
Acromegaly 298 100.00 Very High Very High Very High
Necrosis 136 100.00 Very High Very High Very High
Gigantism 10 100.00 Very High Very High Very High
Disease 1306 99.98 Very High Very High Very High
Carcinoid 132 99.98 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this article we address the question of whether the release of beta-endorphin, an opioid with a potent analgesic effect, could be induced by electrically stimulating stably transfected Neuro-2a cells.
Localization (release) of beta-endorphin in Neuro-2a associated with analgesic and opioid
1) Confidence 0.81 Published 2008 Journal Cell Transplant Section Abstract Doc Link 18714673 Disease Relevance 0 Pain Relevance 0.20
Electrical stimulation-induced release of beta-endorphin from genetically modified neuro-2a cells.
Localization (release) of beta-endorphin
2) Confidence 0.81 Published 2008 Journal Cell Transplant Section Title Doc Link 18714673 Disease Relevance 0 Pain Relevance 0.14
Using electrical field stimulation we were able to identify a stimulation pattern that significantly increased the release of beta-endorphin-immunoreactive material, although to a limited extent.
Localization (release) of beta-endorphin
3) Confidence 0.81 Published 2008 Journal Cell Transplant Section Abstract Doc Link 18714673 Disease Relevance 0 Pain Relevance 0.16
Physical exercise stimulates marked concomitant release of beta-endorphin and adrenocorticotropic hormone (ACTH) in peripheral blood in man.
Localization (release) of ACTH in blood associated with nociceptor
4) Confidence 0.81 Published 1980 Journal Experientia Section Title Doc Link 6254800 Disease Relevance 0.09 Pain Relevance 0.10
Physical exercise stimulates marked concomitant release of beta-endorphin and adrenocorticotropic hormone (ACTH) in peripheral blood in man.
Localization (release) of beta-endorphin in blood associated with nociceptor
5) Confidence 0.81 Published 1980 Journal Experientia Section Title Doc Link 6254800 Disease Relevance 0.09 Pain Relevance 0.10
Physical exercise stimulates marked concomitant release of beta-endorphin and adrenocorticotropic hormone (ACTH) in peripheral blood in man.
Localization (release) of adrenocorticotropic hormone in blood associated with nociceptor
6) Confidence 0.81 Published 1980 Journal Experientia Section Title Doc Link 6254800 Disease Relevance 0.09 Pain Relevance 0.10
In contrast to the correlated circadian fluctuations in beta-LPH, ACTH and beta-endorphin levels therefore, the lack of circadian rhythmicity and dissociation of plasma Met-enkephalin from plasma levels of the former group of peptides suggests control mechanisms for the secretion of Met-enkephalin are quite different and adds support to the concept of separate Met-enkephalin precursors.
Localization (secretion) of Met-enkephalin in plasma associated with enkephalin
7) Confidence 0.81 Published 1981 Journal Brain Res. Section Abstract Doc Link 6261889 Disease Relevance 0 Pain Relevance 0.57
Systemic administration of the enkephalin analog FK 33.824 was previously shown to inhibit ACTH secretion in man.
Localization (secretion) of ACTH associated with enkephalin
8) Confidence 0.81 Published 1983 Journal Life Sci. Section Abstract Doc Link 6402629 Disease Relevance 0.15 Pain Relevance 0.44
In these subjects, significant suppression of metyrapone-evoked release of ACTH and related peptides occurred during D infusion (5.5 micrograms/kg X min for 30 min) compared with that during saline infusion.
Localization (release) of ACTH
9) Confidence 0.81 Published 1985 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2997256 Disease Relevance 0 Pain Relevance 0.16
Dermorphin reduces the metyrapone-evoked release of adrenocorticotropin, beta-endorphin, and beta-lipotropin in man.
Localization (release) of beta-endorphin
10) Confidence 0.81 Published 1985 Journal J. Clin. Endocrinol. Metab. Section Title Doc Link 2997256 Disease Relevance 0 Pain Relevance 0.16
Six normal men were treated with oral metyrapone to stimulate the secretion of ACTH, beta-lipotropin, and beta-endorphin.
Localization (secretion) of ACTH
11) Confidence 0.81 Published 1985 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2997256 Disease Relevance 0 Pain Relevance 0.16
Dermorphin reduces the metyrapone-evoked release of adrenocorticotropin, beta-endorphin, and beta-lipotropin in man.
Localization (release) of beta-lipotropin
12) Confidence 0.81 Published 1985 Journal J. Clin. Endocrinol. Metab. Section Title Doc Link 2997256 Disease Relevance 0 Pain Relevance 0.16
Six normal men were treated with oral metyrapone to stimulate the secretion of ACTH, beta-lipotropin, and beta-endorphin.
Localization (secretion) of beta-lipotropin
13) Confidence 0.81 Published 1985 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2997256 Disease Relevance 0 Pain Relevance 0.16
Six normal men were treated with oral metyrapone to stimulate the secretion of ACTH, beta-lipotropin, and beta-endorphin.
Localization (secretion) of beta-endorphin
14) Confidence 0.81 Published 1985 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2997256 Disease Relevance 0 Pain Relevance 0.16
Dexamethasone produced a significant reversal of exercise-induced pain threshold elevations concomitantly with the suppression of exercise-induced ACTH release.
Localization (release) of ACTH associated with pain threshold and dexamethasone
15) Confidence 0.81 Published 1990 Journal Brain Res. Section Abstract Doc Link 2168784 Disease Relevance 0.27 Pain Relevance 0.65
The effect of dexamethasone on exercise-induced adrenocorticotropin (ACTH) secretion and dental analgesia was studied in healthy human subjects.
Localization (secretion) of ACTH associated with dexamethasone and analgesia
16) Confidence 0.81 Published 1990 Journal Brain Res. Section Abstract Doc Link 2168784 Disease Relevance 0.24 Pain Relevance 0.59
Pre-treatment with iv hydrocortisone (200 mg) completely suppressed both ACTH and beta-endorphin release in response to EA without significantly affecting EA anaesthesia in 6 other patients and in a patient with Addison's disease.
Neg (without) Localization (release) of ACTH associated with disease and electroacupuncture
17) Confidence 0.81 Published 1983 Journal Acta Endocrinol. Section Abstract Doc Link 6310920 Disease Relevance 0.10 Pain Relevance 0.37
Suppression of electroacupuncture(EA)-induced beta-endorphin and ACTH release by hydrocortisone in man.
Localization (release) of beta-endorphin associated with anesthesia and electroacupuncture
18) Confidence 0.81 Published 1983 Journal Acta Endocrinol. Section Title Doc Link 6310920 Disease Relevance 0 Pain Relevance 0.47
Suppression of electroacupuncture(EA)-induced beta-endorphin and ACTH release by hydrocortisone in man.
Localization (release) of ACTH associated with anesthesia and electroacupuncture
19) Confidence 0.81 Published 1983 Journal Acta Endocrinol. Section Title Doc Link 6310920 Disease Relevance 0 Pain Relevance 0.47
Pre-treatment with iv hydrocortisone (200 mg) completely suppressed both ACTH and beta-endorphin release in response to EA without significantly affecting EA anaesthesia in 6 other patients and in a patient with Addison's disease.
Neg (without) Localization (release) of beta-endorphin associated with disease and electroacupuncture
20) Confidence 0.81 Published 1983 Journal Acta Endocrinol. Section Abstract Doc Link 6310920 Disease Relevance 0.10 Pain Relevance 0.37

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