INT4431

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Context Info
Confidence 0.46
First Reported 1975
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 3.53
Pain Relevance 6.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Eda) extracellular region (Eda) molecular_function (Eda)
cellular_component (Eda) biological_process (Eda)
Anatomy Link Frequency
hypothalamus 1
thyroid 1
anterior 1
duodenum 1
limb 1
Eda (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 50 100.00 Very High Very High Very High
analgesia 14 100.00 Very High Very High Very High
epidural 5 100.00 Very High Very High Very High
Pain 4 100.00 Very High Very High Very High
phantom limb 2 100.00 Very High Very High Very High
gABA 18 99.18 Very High Very High Very High
tetrodotoxin 6 98.88 Very High Very High Very High
guanethidine 2 90.96 High High
qutenza 2 79.44 Quite High
GABAergic 4 75.00 Quite High
Disease Link Frequency Relevance Heat
Breast Cancer 23 100.00 Very High Very High Very High
Pain 5 100.00 Very High Very High Very High
Cv Unclassified Under Development 1 99.62 Very High Very High Very High
Disease 2 89.88 High High
Malignant Neoplastic Disease 1 84.04 Quite High
Hemorrhage 1 81.20 Quite High
Cancer 11 75.44 Quite High
Neoplastic Processes 5 74.92 Quite High
Asphyxia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Results obtained show a decrease in EDA activity in hypothalamus, anterior and posterior pituitary, thyroid and ovary, suggesting increased levels of ENK in all these locations.
Negative_regulation (decrease) of EDA in thyroid associated with enkephalin
1) Confidence 0.46 Published 2005 Journal Regul. Pept. Section Abstract Doc Link 15544854 Disease Relevance 0.50 Pain Relevance 0.66
Furthermore, fetal bradycardia was significantly reduced with EDA.
Negative_regulation (reduced) of EDA associated with cv unclassified under development and analgesia
2) Confidence 0.36 Published 1975 Journal Acta Obstet Gynecol Scand Section Abstract Doc Link 1163215 Disease Relevance 0.27 Pain Relevance 1.00
The GABA-induced potentiation of the response to EDA was prevented by nipecotic acid, an inhibitor of GABA uptake.
Negative_regulation (prevented) of EDA associated with gaba
3) Confidence 0.34 Published 1989 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2555721 Disease Relevance 0 Pain Relevance 0.56
The response to EDA was abolished or largely inhibited in preparations excised from rats in which the proximal duodenum was chemically denervated by exposure (2 weeks before), to benzalkonium chloride (BZK).
Negative_regulation (abolished) of EDA in duodenum
4) Confidence 0.34 Published 1989 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2555721 Disease Relevance 0 Pain Relevance 0.84
ENK are hydrolyzed by specific enzymes, leading to their inactivation, such as the enkephalin-degrading tyrosyl aminopeptidase (EDA).
Negative_regulation (inactivation) of EDA associated with enkephalin
5) Confidence 0.33 Published 2005 Journal Anticancer Res. Section Abstract Doc Link 15816538 Disease Relevance 0.51 Pain Relevance 0.45
AIM: A recently published randomized study failed to show a significant reduction of phantom limb pain after perioperative epidural analgesia EDA [9].
Negative_regulation (reduction) of EDA in limb associated with pain, phantom limb, epidural and analgesia
6) Confidence 0.18 Published 2003 Journal Schmerz Section Abstract Doc Link 12579385 Disease Relevance 0.26 Pain Relevance 0.68
Results obtained show a decrease in EDA activity in hypothalamus, anterior and posterior pituitary, thyroid and ovary, suggesting increased levels of ENK in all these locations.
Negative_regulation (decrease) of EDA in hypothalamus associated with enkephalin
7) Confidence 0.16 Published 2005 Journal Regul. Pept. Section Abstract Doc Link 15544854 Disease Relevance 0.50 Pain Relevance 0.66
Results obtained show a decrease in EDA activity in hypothalamus, anterior and posterior pituitary, thyroid and ovary, suggesting increased levels of ENK in all these locations.
Negative_regulation (decrease) of EDA in ovary associated with enkephalin
8) Confidence 0.16 Published 2005 Journal Regul. Pept. Section Abstract Doc Link 15544854 Disease Relevance 0.50 Pain Relevance 0.66
Results obtained show a decrease in EDA activity in hypothalamus, anterior and posterior pituitary, thyroid and ovary, suggesting increased levels of ENK in all these locations.
Negative_regulation (decrease) of EDA in posterior pituitary associated with enkephalin
9) Confidence 0.16 Published 2005 Journal Regul. Pept. Section Abstract Doc Link 15544854 Disease Relevance 0.50 Pain Relevance 0.66
Results obtained show a decrease in EDA activity in hypothalamus, anterior and posterior pituitary, thyroid and ovary, suggesting increased levels of ENK in all these locations.
Negative_regulation (decrease) of EDA in anterior associated with enkephalin
10) Confidence 0.16 Published 2005 Journal Regul. Pept. Section Abstract Doc Link 15544854 Disease Relevance 0.50 Pain Relevance 0.66

General Comments

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