INT44316

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Context Info
Confidence 0.16
First Reported 1981
Last Reported 1983
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.15
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
nerve 1
Dpa (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 27 100.00 Very High Very High Very High
withdrawal 3 100.00 Very High Very High Very High
Morphine 4 98.12 Very High Very High Very High
antagonist 1 95.72 Very High Very High Very High
Glutamate 1 55.60 Quite High
Disease Link Frequency Relevance Heat
Syndrome 1 97.00 Very High Very High Very High
Generalized Anxiety Disorder 1 53.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inhibitory action of DPA on GABA degradation, resulting in an enhanced release of GABA, is probably responsible for this behavioral effect, since GABA antagonists, like bicuculline and picrotoxin, have been shown to suppress this behavior.
Protein_catabolism (degradation) of DPA associated with gaba and antagonist
1) Confidence 0.16 Published 1981 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 6791219 Disease Relevance 0.10 Pain Relevance 0.51
It has been postulated that DPA elicits the withdrawal like behaviour through specifically inhibiting the GABA-degradation in nerve terminals.
Protein_catabolism (degradation) of DPA in nerve associated with gaba and withdrawal
2) Confidence 0.04 Published 1983 Journal Life Sci. Section Abstract Doc Link 6420629 Disease Relevance 0.05 Pain Relevance 0.86

General Comments

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