INT4435

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Context Info
Confidence 0.77
First Reported 1975
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 20
Total Number 22
Disease Relevance 14.43
Pain Relevance 2.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (PIK3C2A) plasma membrane (PIK3C2A) nucleus (PIK3C2A)
cytoplasm (PIK3C2A)
Anatomy Link Frequency
blood 2
liver 2
quadriceps 1
thyroid 1
nervous tissue 1
PIK3C2A (Homo sapiens)
Pain Link Frequency Relevance Heat
corticosteroid 2 98.84 Very High Very High Very High
cva 12 97.92 Very High Very High Very High
Thoracotomy 1 97.16 Very High Very High Very High
Pain 21 96.64 Very High Very High Very High
anesthesia 4 96.64 Very High Very High Very High
Arthritis 5 92.72 High High
Percutaneous transluminal coronary angioplasty 3 91.28 High High
alcohol 7 89.92 High High
headache 2 83.44 Quite High
ischemia 5 83.20 Quite High
Disease Link Frequency Relevance Heat
Disorders Of Creatine Metabolism 43 100.00 Very High Very High Very High
Fever 8 99.92 Very High Very High Very High
Arrhythmia Under Development 2 99.42 Very High Very High Very High
Myocardial Infarction 30 98.92 Very High Very High Very High
Exanthema 4 98.86 Very High Very High Very High
Polymyositis 7 98.74 Very High Very High Very High
Hypercalcemia 15 98.12 Very High Very High Very High
Cv General 3 Under Development 10 97.92 Very High Very High Very High
Leukocytosis 1 97.50 Very High Very High Very High
Ectopic Pregnancy 20 97.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results showed the following: (1) high incidence of various dysrhythmias occurring during anesthesia induction and thoracotomy prior to aortic cross-clamp; (2) high incidence of continued atrial activity during cardioplegia; (3) lack of correlation between peak serum CPK-MB levels and dysrhythmias; and (4) a higher overall incidence of dysrhythmias in valve patients.
Gene_expression (levels) of CPK-MB associated with anesthesia and thoracotomy
1) Confidence 0.77 Published 1985 Journal Chest Section Abstract Doc Link 3872775 Disease Relevance 0 Pain Relevance 0.21
Primary laboratory analysis showed leukocytosis with left shift, hypercalcemia, mildly elevated liver enzymes, elevated creatinine level, and a significant increase in the levels of amylase, lipase and creatine protein kinase (CPK) (Table 1).
Gene_expression (levels) of CPK in liver associated with leukocytosis and hypercalcemia
2) Confidence 0.75 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2596162 Disease Relevance 0.84 Pain Relevance 0.25
The patients had postoperative ECG and creatinine phosphokinase (CPK) isoenzyme determinations and regularly scheduled clinical examinations to detect perioperative myocardial infarction and neurologic deficits.
Gene_expression (scheduled) of CPK associated with neurologic manifestations and myocardial infarction
3) Confidence 0.65 Published 1988 Journal Anesthesiology Section Abstract Doc Link 3195756 Disease Relevance 0.68 Pain Relevance 0.41
Blood pressure slowly decreased to 60 mmHg, blood CPK levels reached 135 000 U/L, blood hemoglobin decreased to 6.9 g/dL, and platelets decreased to 100 000 mm3.
Gene_expression (levels) of CPK in Blood
4) Confidence 0.65 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661629 Disease Relevance 0.44 Pain Relevance 0.11
Serum levels of aldose, CPK, ASAT and ALAT were increased but ordinary light microscopy revealed no histological signs of muscle disease in a quadriceps biopsy.
Gene_expression (levels) of CPK in quadriceps associated with muscle disease
5) Confidence 0.58 Published 1975 Journal Acta Med Scand Section Abstract Doc Link 1166819 Disease Relevance 0.73 Pain Relevance 0.09
Similarly, in a child with an erythematous, hyperkeratotic rash across her MCP and PIP joints (Gotron's papules), serum levels of CPK and/or aldolase are very likely to reveal that the underlying diagnosis is dermatomyositis [16].
Gene_expression (levels) of CPK in papules associated with exanthema and dermatomyositis
6) Confidence 0.58 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2588570 Disease Relevance 1.03 Pain Relevance 0.23
Secondary outcomes included total cholesterol, high-density lipoprotein (HDL) cholesterol, triglyceride, liver enzyme, and creatinine phosphokinase (CPK) levels; weight; and Brief Pain Inventory score.
Gene_expression (levels) of CPK in liver
7) Confidence 0.58 Published 2009 Journal Ann. Intern. Med. Section Body Doc Link 19528562 Disease Relevance 0 Pain Relevance 0
The levels of myoglobin, CPK, LDH, AST, ALT, MB CPK and LDH1 were determined in the blood serum of the patients in the time course during the first 24 hours of hospitalization.
Spec (determined) Gene_expression (levels) of CPK in blood
8) Confidence 0.58 Published 1982 Journal Kardiologiia Section Abstract Doc Link 7098273 Disease Relevance 0.25 Pain Relevance 0.05
The mild ECG changes in the basal leads and the normal MB creatinine phosphokinase fraction, expressed as a percentage of total CPK, delayed the diagnosis of myocardial infarction.
Gene_expression (expressed) of CPK associated with myocardial infarction
9) Confidence 0.58 Published 1993 Journal Arch Mal Coeur Vaiss Section Abstract Doc Link 8239878 Disease Relevance 0.59 Pain Relevance 0
CPK was elevated in nine patients (up to 30,000); in six patients CPK was not determined.
Neg (not) Spec (determined) Gene_expression (determined) of CPK
10) Confidence 0.58 Published 1995 Journal Langenbecks Arch Chir Section Abstract Doc Link 8558998 Disease Relevance 0.70 Pain Relevance 0.14
Although serum levels of CPK and the ratio of CPK/progesterone are the most helpful in making the diagnosis of early ectopic pregnancy, they are not good enough to be used alone in clinical practice.
Gene_expression (levels) of CPK associated with disorders of creatine metabolism and ectopic pregnancy
11) Confidence 0.57 Published 2000 Journal J Womens Health Gend Based Med Section Abstract Doc Link 10883946 Disease Relevance 1.69 Pain Relevance 0
CPK MB was high but troponin was negative.
Gene_expression (high) of CPK
12) Confidence 0.51 Published 2000 Journal Can J Anaesth Section Body Doc Link 11097539 Disease Relevance 0 Pain Relevance 0
Treatment with levothyroxine was initiated and within 2 months normalization of renal function, myoglobin, CPK and thyroid hormone levels was observed.
Gene_expression (levels) of CPK in thyroid
13) Confidence 0.45 Published 2010 Journal G Ital Nefrol Section Abstract Doc Link 20672239 Disease Relevance 0.82 Pain Relevance 0.17
This case is considered to be associated with cardiac involvement of polymyositis because of ventricular arrhythmia, persistent increased serum levels of CPK-MB, and the marked benefits of corticosteroid against unstable angina.
Gene_expression (levels) of CPK-MB associated with corticosteroid, arrhythmia under development, polymyositis and cva
14) Confidence 0.45 Published 1992 Journal Kokyu To Junkan Section Abstract Doc Link 1589649 Disease Relevance 1.04 Pain Relevance 0.49
Laboratory data on admission showed remarkable elevation of muscle enzymes (AST, LDH, CPK) and serum levels of myoglobin, BUN, and Cr.
Gene_expression (levels) of CPK in muscle
15) Confidence 0.26 Published 2002 Journal Nihon Arukoru Yakubutsu Igakkai Zasshi Section Abstract Doc Link 12462066 Disease Relevance 1.19 Pain Relevance 0.09
Although serum levels of CPK and the ratio of CPK/progesterone are the most helpful in making the diagnosis of early ectopic pregnancy, they are not good enough to be used alone in clinical practice.
Gene_expression (levels) of CPK associated with disorders of creatine metabolism and ectopic pregnancy
16) Confidence 0.25 Published 2000 Journal J Womens Health Gend Based Med Section Abstract Doc Link 10883946 Disease Relevance 1.69 Pain Relevance 0
Levels of CPK should be assessed in patients reporting these symptoms, and fibrate therapy should be discontinued if markedly elevated CPK levels (10 times the upper limit of normal) occur or myopathy is diagnosed.


Gene_expression (Levels) of CPK in upper associated with muscle disease
17) Confidence 0.20 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464751 Disease Relevance 1.04 Pain Relevance 0.13
It is likely that the source of the elevated serum CPK in this case is from damage to the nervous tissue.
Gene_expression (source) of serum CPK in nervous tissue
18) Confidence 0.20 Published 2007 Journal Environ Health Section Body Doc Link PMC1821321 Disease Relevance 0.05 Pain Relevance 0
Only one patient (4.8%) discontinued due to plitidepsin-related increase in creatine phosphokinase (CPK) levels after three cycles.

3.3.

Gene_expression (levels) of CPK associated with disorders of creatine metabolism
19) Confidence 0.15 Published 2009 Journal Marine Drugs Section Body Doc Link PMC2763111 Disease Relevance 0.92 Pain Relevance 0.06
The use of corticosteroids, particularly dantrolene [6], has led to a slight increase in strength with relative decreases in the levels of CPK.
Gene_expression (levels) of CPK associated with corticosteroid and disorders of creatine metabolism
20) Confidence 0.11 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2912795 Disease Relevance 0.28 Pain Relevance 0.05

General Comments

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