INT4436

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Context Info
Confidence 0.65
First Reported 1975
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 13
Disease Relevance 9.26
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCB7) mitochondrion (ABCB7) ATPase activity (ABCB7)
transmembrane transport (ABCB7) cytoplasm (ABCB7)
Anatomy Link Frequency
respiratory 2
quadriceps 1
upper 1
ABCB7 (Homo sapiens)
Pain Link Frequency Relevance Heat
Migraine 1 95.96 Very High Very High Very High
Pain 18 89.20 High High
cva 13 87.20 High High
Inflammation 51 79.48 Quite High
cytokine 65 78.08 Quite High
Inflammatory response 2 77.96 Quite High
alcohol 3 75.60 Quite High
antidepressant 10 71.16 Quite High
corticosteroid 8 63.00 Quite High
Glutamate 10 57.80 Quite High
Disease Link Frequency Relevance Heat
Sideroblastic Anemia 105 100.00 Very High Very High Very High
Porphyria 35 100.00 Very High Very High Very High
Adult Respiratory Distress Syndrome 13 100.00 Very High Very High Very High
Acute Renal Failure 5 100.00 Very High Very High Very High
Anaemia 127 99.78 Very High Very High Very High
Disease 214 99.66 Very High Very High Very High
Iron Overload 168 99.48 Very High Very High Very High
Disorders Of Creatine Metabolism 1 99.24 Very High Very High Very High
Peripheral Arterial Disease 16 98.62 Very High Very High Very High
Ataxia 168 98.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AF: alkaline phosphatase; ALAT: alanine aminotransferase; APTT: activated partial thromboplastin time; ARDS: adult respiratory distress syndrome; ARF: acute renal failure; ASAT: aspartate aminotransferase; C-RP: C-reactive protein; CT: computed tomography; DIC: disseminated intravascular coagulation; ?
Gene_expression (adult) of ASAT in respiratory associated with acute renal failure, disseminated intravascular coagulation and adult respiratory distress syndrome
1) Confidence 0.65 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2584008 Disease Relevance 0.95 Pain Relevance 0.14
AF: alkaline phosphatase; ALAT: alanine aminotransferase; APTT: activated partial thromboplastin time; ARDS: adult respiratory distress syndrome; ARF: acute renal failure; ASAT: aspartate aminotransferase; C-RP: C-reactive protein; CT: computed tomography; DIC: disseminated intravascular coagulation; ?
Gene_expression (alanine aminotransferase) of ASAT in respiratory associated with acute renal failure, disseminated intravascular coagulation and adult respiratory distress syndrome
2) Confidence 0.65 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2584008 Disease Relevance 0.97 Pain Relevance 0.15
Serum levels of aldose, CPK, ASAT and ALAT were increased but ordinary light microscopy revealed no histological signs of muscle disease in a quadriceps biopsy.
Gene_expression (levels) of ASAT in quadriceps associated with muscle disease
3) Confidence 0.59 Published 1975 Journal Acta Med Scand Section Abstract Doc Link 1166819 Disease Relevance 0.74 Pain Relevance 0.09
sulfur cluster biogenesis in three human diseases, and the problems that are engendered in mitochondrial and cytosolic iron homeostasis, we suggest that the next frontier will consist of molecular characterization of a molecule synthesized in mitochondria that is exported to the cytosolic/nuclear compartment, perhaps by ABCB7, and which represents a gauge of mitochondrial iron status by possessing or depending on an iron?
Gene_expression (exported) of ABCB7 associated with disease
4) Confidence 0.59 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.17 Pain Relevance 0
On the basis of the fact that mutations of SLC25A38, SLC19A2, ABCB7, and heme synthetic ALAS2 all cause a similar sideroblastic anemia phenotype (80) and the prediction that SLC25A38 may provide the glycine substrate of heme biosynthesis and SLC19A2 may provide thiamine for pyruvate dehydrogenase, it is possible that ABCB7 exports a heme or heme precursor molecule to the cytosol that conveys a signal about mitochondrial iron status to the cytosolic/nuclear compartment.
Gene_expression (biosynthesis) of ABCB7 associated with porphyria and sideroblastic anemia
5) Confidence 0.59 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.50 Pain Relevance 0
However, since human patients with mutations of FECH, which catalyzes the last step in heme synthesis, do not usually show mitochondrial iron overload, we hypothesize that the ABCB7 substrate could be a product of an earlier step in heme synthesis.
Gene_expression (product) of ABCB7 associated with iron overload
6) Confidence 0.59 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.53 Pain Relevance 0
S proteins such as Leu1p and that its homologue ABCB7 exported Fe?
Gene_expression (proteins) of ABCB7
7) Confidence 0.59 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.54 Pain Relevance 0
The Mitochondrial ATP Binding Cassette Protein, ABCB7, X-Linked Sideroblastic Anemia and Ataxia Syndrome (XLSA/A), and a Proposed Connection to Iron?
Gene_expression (The) of ABCB7 associated with ataxia, sideroblastic anemia and syndrome
8) Confidence 0.59 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 1.24 Pain Relevance 0.11
In animal models, ABCB7 depletion decreases the rate of cytosolic Fe?
Gene_expression (depletion) of ABCB7
9) Confidence 0.59 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.17 Pain Relevance 0
Human ABCB7 has an additional role in heme synthesis and hematopoiesis as revealed by a putative interaction between ABCB7 and FECH which has been demonstrated in pull-down assays, and anemia caused by ABCB7 depletion (83,84).
Gene_expression (depletion) of ABCB7 associated with hematological disease and anaemia
10) Confidence 0.51 Published 2010 Journal Biochemistry Section Body Doc Link PMC2885827 Disease Relevance 0.71 Pain Relevance 0
Other exclusion criteria were as follows: previous exposure to the drug; history of hypersensitivity to amiloride (a structurally related compound); noncardiac progressive fatal disease; known ALAT and ASAT levels exceeding three times the upper limit of normal or known bilirubin >1.75 mg/dl (>30 ?
Gene_expression (levels) of ASAT in upper associated with hypersensitivity and disease
11) Confidence 0.38 Published 2000 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC56207 Disease Relevance 1.14 Pain Relevance 0.17
PVD subjects have often an altered drug sensitivity due to differential expression of ATP-Binding Cassette (ABC) transporter proteins [31].
Gene_expression (expression) of ATP-Binding Cassette associated with peripheral arterial disease
12) Confidence 0.18 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2267728 Disease Relevance 1.08 Pain Relevance 0.10
This increase in ALAT and ASAT levels was most pronounced at week three.
Gene_expression (levels) of ASAT
13) Confidence 0.16 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687935 Disease Relevance 0.53 Pain Relevance 0.16

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