INT4437

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Context Info
Confidence 0.68
First Reported 1975
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 11.26
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCB7) mitochondrion (ABCB7) ATPase activity (ABCB7)
transmembrane transport (ABCB7) cytoplasm (ABCB7)
Anatomy Link Frequency
muscle 2
blood 1
plasma 1
quadriceps 1
ABCB7 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 8 98.96 Very High Very High Very High
Pain 32 96.32 Very High Very High Very High
Chronic pancreatitis 3 94.72 High High
cva 16 84.28 Quite High
dysesthesia 8 83.08 Quite High
cytokine 126 77.52 Quite High
headache 6 77.00 Quite High
antidepressant 20 76.56 Quite High
Bile 2 75.32 Quite High
Inflammation 88 62.96 Quite High
Disease Link Frequency Relevance Heat
Thrombocytopenia 24 99.80 Very High Very High Very High
Disorders Of Creatine Metabolism 6 99.76 Very High Very High Very High
Injury 12 99.36 Very High Very High Very High
Toxicity 4 99.32 Very High Very High Very High
Cholangitis 1 99.32 Very High Very High Very High
Leukopenia 8 99.28 Very High Very High Very High
Rhabdomyolysis 4 99.28 Very High Very High Very High
Congenital Anomalies 16 98.88 Very High Very High Very High
Weight Gain 15 98.32 Very High Very High Very High
Appetite Loss 46 98.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serum levels of aldose, CPK, ASAT and ALAT were increased but ordinary light microscopy revealed no histological signs of muscle disease in a quadriceps biopsy.
Positive_regulation (increased) of ASAT in quadriceps associated with muscle disease
1) Confidence 0.68 Published 1975 Journal Acta Med Scand Section Abstract Doc Link 1166819 Disease Relevance 0.74 Pain Relevance 0.09
One patient with cholangitis secondary to EHC had a transient elevation of the ASAT/ALAT ratio to above 2.5.
Positive_regulation (elevation) of ASAT associated with cholangitis
2) Confidence 0.67 Published 1985 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 4048836 Disease Relevance 1.10 Pain Relevance 0.27
A slight elevation of ASAT and ALAT was noted in seven patients and weight gain in two.
Positive_regulation (elevation) of ASAT associated with weight gain
3) Confidence 0.67 Published 1980 Journal Z Rheumatol Section Abstract Doc Link 7424193 Disease Relevance 0.35 Pain Relevance 0.10
Routine laboratory examinations only revealed mild increases of the aspartate aminotranspherase (ASAT) and creatine phosphokinase (CPK), which later normalized.
Positive_regulation (increases) of ASAT associated with disorders of creatine metabolism
4) Confidence 0.67 Published 2007 Journal J Neurol Section Body Doc Link PMC2779429 Disease Relevance 1.16 Pain Relevance 0.06
These results suggest that the increase in the serum level of ASAT was partially related to muscle injury, with 60% of the patients with increased ASAT also presented a rhabdomyolysis.
Positive_regulation (increased) of ASAT in muscle associated with rhabdomyolysis and injury
5) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2764049 Disease Relevance 1.38 Pain Relevance 0.09
These results suggest that the increase in the serum level of ASAT was partially related to muscle injury, with 60% of the patients with increased ASAT also presented a rhabdomyolysis.
Positive_regulation (increase) of ASAT in muscle associated with rhabdomyolysis and injury
6) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2764049 Disease Relevance 1.40 Pain Relevance 0.09
The serum ASAT level was increased for 32% of the patients as opposed to only 7% for the ALAT.
Positive_regulation (increased) of ASAT
7) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2764049 Disease Relevance 1.44 Pain Relevance 0.10
Others biological abnormalities included leukopenia (38.3%), thrombocytopenia (37.3%), increased ASAT and ALAT blood levels (31.6 and 7.3%, respectively) and hypocalcemia (38.7%).
Positive_regulation (increased) of ASAT in blood associated with hypocalcemia, leukopenia, congenital anomalies and thrombocytopenia
8) Confidence 0.24 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2764049 Disease Relevance 1.84 Pain Relevance 0.20
While two patients were observed to have an increase in aspartate amino transferase (ASAT), these levels returned to normal once CLA was discontinued (P = .002, CLA-FFA; P = .009, CLA-triacylglycerol).
Positive_regulation (increase) of ASAT
9) Confidence 0.19 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2931392 Disease Relevance 0.65 Pain Relevance 0
In a study on liver enzyme levels during psychopharmacological treatment in patients who received a stable psychopharmacological treatment, an increase in aspartate-aminotrans-ferase (ASAT) and alanine-amino transferase (ALAT) plasma levels was found.
Positive_regulation (increase) of ASAT in plasma
10) Confidence 0.16 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687935 Disease Relevance 0.60 Pain Relevance 0.16
This increase in ALAT and ASAT levels was most pronounced at week three.
Positive_regulation (increase) of ASAT
11) Confidence 0.11 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687935 Disease Relevance 0.59 Pain Relevance 0.16

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