INT44371

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.31
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.70
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ALOX5) nuclear envelope (ALOX5) small molecule metabolic process (ALOX5)
oxidoreductase activity (ALOX5) nucleus (ALOX5) cytoplasm (ALOX5)
Anatomy Link Frequency
chondrocytes 2
teeth 2
ALOX5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 88 99.72 Very High Very High Very High
aspirin 2 95.44 Very High Very High Very High
Inflammation 36 75.00 Quite High
cINOD 5 63.56 Quite High
metalloproteinase 14 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
licofelone 6 5.00 Very Low Very Low Very Low
COX-2 inhibitor 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 96 99.72 Very High Very High Very High
INFLAMMATION 47 75.00 Quite High
Hypersensitivity 1 61.12 Quite High
Dental Caries 13 5.00 Very Low Very Low Very Low
Disease 13 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Osteophyte 2 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of the 15-lipoxygenase by ibuprofen occurred within 1 min and was readily reversible.
Positive_regulation (occurred) of Positive_regulation (Activation) of lipoxygenase
1) Confidence 0.31 Published 1984 Journal J. Biol. Chem. Section Abstract Doc Link 6427221 Disease Relevance 0.26 Pain Relevance 0.22
When dmft was the dependent variable, it was observed that with increasing parental LoC a chance for their children to have intact teeth increased.
Positive_regulation (increased) of Positive_regulation (increasing) of LoC in teeth
2) Confidence 0.30 Published 2008 Journal BMC Public Health Section Body Doc Link PMC2442069 Disease Relevance 0 Pain Relevance 0
Taken together, these results indicate that single treatment with HNE in OA chondrocytes induced the shunt from the production of PGE2 to LTB4 through COX-2 downregulation and 5-LOX and FLAP upregulation.


Positive_regulation (induced) of Positive_regulation (upregulation) of 5-LOX in chondrocytes associated with osteoarthritis
3) Confidence 0.16 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.37 Pain Relevance 0.19
Incubation of cells with naproxen, however, caused a consistent increase of 5-LOX mRNA level by 330% and 570% of control values (P < 0.001) after 24 and 72 hours of incubation, respectively (Figure 6c, d).
Positive_regulation (caused) of Positive_regulation (increase) of 5-LOX
4) Confidence 0.15 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.07 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox