INT44378

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Context Info
Confidence 0.76
First Reported 1984
Last Reported 2010
Negated 1
Speculated 4
Reported most in Body
Documents 69
Total Number 73
Disease Relevance 34.61
Pain Relevance 8.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GSTM1) small molecule metabolic process (GSTM1) cytoplasm (GSTM1)
Anatomy Link Frequency
neurons 5
cochlea 2
brain 2
skin 2
lung 2
GSTM1 (Homo sapiens)
GSTM1 - I1575A (1)
Pain Link Frequency Relevance Heat
mu opioid receptor 16 100.00 Very High Very High Very High
Electroencephalography 272 99.98 Very High Very High Very High
Pyramidal cell 4 99.84 Very High Very High Very High
Inflammatory response 28 99.60 Very High Very High Very High
Inflammation 232 99.50 Very High Very High Very High
opiate 4 99.14 Very High Very High Very High
dorsal root ganglion 12 98.68 Very High Very High Very High
imagery 23 98.40 Very High Very High Very High
melanocortin 1 receptor 8 98.32 Very High Very High Very High
Crohn's disease 7 97.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Sprains And Strains 285 100.00 Very High Very High Very High
Nicotine Addiction 904 99.92 Very High Very High Very High
Coronary Artery Disease 419 99.84 Very High Very High Very High
Obesity 116 99.72 Very High Very High Very High
Lung Cancer 30 99.70 Very High Very High Very High
Helminth Infection 45 99.60 Very High Very High Very High
INFLAMMATION 275 99.50 Very High Very High Very High
Rheumatoid Arthritis 58 99.24 Very High Very High Very High
Myocardial Infarction 53 99.04 Very High Very High Very High
Hypercholesterolemia 25 98.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cytochrome P450 2D6 (CYP2D6) and glutathione S-transferase M1 (GSTM1) are thought to be present in the brain.
Gene_expression (present) of glutathione S-transferase M1 in brain
1) Confidence 0.76 Published 2000 Journal Eur. J. Clin. Invest. Section Abstract Doc Link 10759887 Disease Relevance 0.53 Pain Relevance 0.43
Cytochrome P450 2D6 (CYP2D6) and glutathione S-transferase M1 (GSTM1) are thought to be present in the brain.
Gene_expression (present) of GSTM1 in brain
2) Confidence 0.76 Published 2000 Journal Eur. J. Clin. Invest. Section Abstract Doc Link 10759887 Disease Relevance 0.52 Pain Relevance 0.43
We tested this single receptor hypothesis using mutant muscle Na+ channels of mu1-I1575A, F1579A, and N1584A transiently expressed in Hek-293t cells.
Gene_expression (expressed) of mu1 (I1575A) in muscle
3) Confidence 0.75 Published 1998 Journal Pflugers Arch. Section Abstract Doc Link 9382945 Disease Relevance 0 Pain Relevance 0.21
GST-M1 and GST-P1 are both expressed at the corti organ,[17] which is affected in case of cisplatin-induced ototoxicity.
Gene_expression (expressed) of GST-P1
4) Confidence 0.73 Published 2007 Journal J Transl Med Section Body Doc Link PMC2245909 Disease Relevance 0.41 Pain Relevance 0.05
GST-M1 and GST-P1 are both expressed at the corti organ,[17] which is affected in case of cisplatin-induced ototoxicity.
Gene_expression (expressed) of GST-M1
5) Confidence 0.73 Published 2007 Journal J Transl Med Section Body Doc Link PMC2245909 Disease Relevance 0.41 Pain Relevance 0.05
We acquired data for GSTM1 gene and GSTT1 gene polymorphisms in 692 subjects (89.3%) due to missing data of gene analysis (missing data [83]: group A [47], B [34], and C [2]).


Gene_expression (gene) of GSTM1
6) Confidence 0.67 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526535 Disease Relevance 0.90 Pain Relevance 0
Considering the synergistic effects of GSTM1 null genotype and GSTT1 null genotype on risk of smoking-related CAD, we found that smokers with both GSTM1 and GSTT1 null genotype were at an approximately 2.76-fold higher risk of CAD than nonsmokers with both GSTM1 and GSTT1 positive genotype (CI, 1.17-6.52, p=0.04)
Gene_expression (genotype) of GSTM1 associated with coronary artery disease and nicotine addiction
7) Confidence 0.67 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526535 Disease Relevance 2.41 Pain Relevance 0
The association between the concentrations of PCBs, GSTM1 null genotype and different severity of endometriosis was significant (P<0.05) for all four compounds and GSTM1 (PCB1: r = +0.5388, P<0.0001; PCB5: r = +0.6753, P<0.0001; PCB29: r = +0.6471, P<0.0001; and PCB98: r = +0.4357, P<0.0001; GSTM1: r = +0.9439, P = 0.05).
Gene_expression (significant) of GSTM1
8) Confidence 0.67 Published 2009 Journal Indian J. Med. Res. Section Body Doc Link 19535834 Disease Relevance 0.07 Pain Relevance 0
Table 3 shows the distribution of NAT2, GSTM1, GSTT1, and GSTP1 genotypes by self-reported chemical-related sensitivity score (?
Gene_expression (distribution) of GSTM1
9) Confidence 0.67 Published 2007 Journal Environ Health Section Body Doc Link PMC1802749 Disease Relevance 0.18 Pain Relevance 0
Allelic loss of the GSTM1 and the GSTP1 (Ile105Val) polymorphism were determined by PCR and RFLP.
Gene_expression (loss) of GSTM1
10) Confidence 0.67 Published 2006 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2721922 Disease Relevance 1.17 Pain Relevance 0.25
Particularly, smokers with combination of GSTM1 null and GSTP1 AG or GG genotypes showed higher TNF-?
Gene_expression (null) of GSTM1 associated with nicotine addiction
11) Confidence 0.67 Published 2006 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2721922 Disease Relevance 1.15 Pain Relevance 0.24
In the linear regression analysis after adjustment of age, sex, and BMI, none of the GSTM1 and GSTP1 genotypes showed statistically significant effect on the relation between serum TNF-?
Gene_expression (genotypes) of GSTM1 associated with obesity
12) Confidence 0.67 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721922 Disease Relevance 0.96 Pain Relevance 0.07
Combination of GSTM1 null and GSTP1 AG or GG genotypes in subjects with pack year or cotinine level over zero showed higher TNF-?
Gene_expression (null) of GSTM1
13) Confidence 0.67 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721922 Disease Relevance 0.70 Pain Relevance 0.05
In their study, when the effects of combined GSTM1 and GSTP1 genotypes on DNA adduct formation were examined, lung cancer patients with GSTM1 null and GSTP1 AG or GG genotype combinations had significantly higher carcinogen-derived DNA adduct level in lung tissue than those with the other genotype combinations.
Gene_expression (null) of GSTM1 in lung associated with lung cancer
14) Confidence 0.67 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721922 Disease Relevance 0.79 Pain Relevance 0.21
Absence of GSTM1 or GSTT1 can be attributed to absence of the GSTM1 or GSTT1 gene products (null genotype) in approximately 50% and 20% of the Caucasian population, respectively.
Gene_expression (products) of GSTM1
15) Confidence 0.67 Published 2003 Journal Am. J. Med. Genet. A Section Abstract Doc Link 12794689 Disease Relevance 0.41 Pain Relevance 0.36
DNA was analyzed for deletions in the GSTM1 and T1 genes and for substitutions in EPXH and GSTP1 genes.
Spec (analyzed) Gene_expression (deletions) of GSTM1
16) Confidence 0.64 Published 2000 Journal FASEB J. Section Abstract Doc Link 10744635 Disease Relevance 1.23 Pain Relevance 0.09
The absence of amplified GSTM1 or GSTT1 product (in the presence of the albumin PCR product) indicated the respective null genotype for each.
Gene_expression (product) of GSTM1
17) Confidence 0.64 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1779469 Disease Relevance 0.28 Pain Relevance 0.03
Univariate analysis showed that the following variables were associated with the manifestation of CAD: GSTT1 genotype (p < .001), GSTM genotype (p < .001), haplotype GSTT1 plus GSTM1 (p < .001), smoking, age, elevated cholesterol and triglycerides, diabetes mellitus (DM), family history of CAD (FH), hypertension and obesity, whereas gender (p = .1) and myocardial infarction (MI) on admission (p = .067) were not.
Gene_expression (genotype) of GSTM associated with nicotine addiction, coronary artery disease, diabetes mellitus, obesity, hypertension, myocardial infarction and hypercholesterolemia
18) Confidence 0.64 Published 2006 Journal BMC Med Genet Section Body Doc Link PMC1458325 Disease Relevance 1.37 Pain Relevance 0
Univariate analysis showed that the following variables were associated with the manifestation of CAD: GSTT1 genotype (p < .001), GSTM genotype (p < .001), haplotype GSTT1 plus GSTM1 (p < .001), smoking, age, elevated cholesterol and triglycerides, diabetes mellitus (DM), family history of CAD (FH), hypertension and obesity, whereas gender (p = .1) and myocardial infarction (MI) on admission (p = .067) were not.
Gene_expression (haplotype) of GSTM1 associated with nicotine addiction, coronary artery disease, diabetes mellitus, obesity, hypertension, myocardial infarction and hypercholesterolemia
19) Confidence 0.64 Published 2006 Journal BMC Med Genet Section Body Doc Link PMC1458325 Disease Relevance 1.39 Pain Relevance 0
Univariate analysis showed that the following variables were associated with the manifestation of CAD: GSTT1 genotype (p < .001), GSTM genotype (p < .001), haplotype GSTT1 plus GSTM1 (p < .001), smoking, age, elevated cholesterol and triglycerides, diabetes mellitus (DM), family history of CAD (FH), hypertension and obesity, whereas gender (p = .1) and myocardial infarction (MI) on admission (p = .067) were not.
Gene_expression (genotype) of GSTM1 associated with nicotine addiction, coronary artery disease, diabetes mellitus, obesity, hypertension, myocardial infarction and hypercholesterolemia
20) Confidence 0.64 Published 2006 Journal BMC Med Genet Section Body Doc Link PMC1458325 Disease Relevance 1.40 Pain Relevance 0

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