INT4438

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Context Info
Confidence 0.59
First Reported 1975
Last Reported 1998
Negated 0
Speculated 2
Reported most in Abstract
Documents 18
Total Number 20
Disease Relevance 6.23
Pain Relevance 6.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Adh1) mitochondrion (Adh1) oxidoreductase activity (Adh1)
intracellular (Adh1) embryo development (Adh1) cytoplasm (Adh1)
Anatomy Link Frequency
blood 14
cardiovascular system 4
heart 2
neurohypophysis 2
urine 2
Adh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 2 100.00 Very High Very High Very High
Clonidine 75 99.98 Very High Very High Very High
butorphanol 12 99.98 Very High Very High Very High
antagonist 11 99.58 Very High Very High Very High
agonist 4 95.22 Very High Very High Very High
tolerance 4 90.20 High High
Morphine 4 83.92 Quite High
transdermal 2 75.00 Quite High
anesthesia 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Depression 2 100.00 Very High Very High Very High
Diuresis 37 99.92 Very High Very High Very High
Hypothermia 8 99.74 Very High Very High Very High
Volume Depletion And Dehydration 3 99.36 Very High Very High Very High
Diabetes Insipidus 8 98.84 Very High Very High Very High
Pressure And Volume Under Development 3 98.84 Very High Very High Very High
Pressure Volume 2 Under Development 13 97.76 Very High Very High Very High
Heart Rate Under Development 7 93.08 High High
Natriuresis 1 87.72 High High
Sleep Disorders 4 84.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The data indicate that these narcotic antagonists cause a diuresis by inhibiting ADH release from the neurohypophysis.
Negative_regulation (inhibiting) of Localization (release) of ADH in neurohypophysis associated with diuresis and antagonist
1) Confidence 0.59 Published 1975 Journal Neuroendocrinology Section Abstract Doc Link 1223660 Disease Relevance 0.26 Pain Relevance 0.49
Butorphanol prevented the expected rise in urine osmolality and ADH excretion due to 31 h of dehydration.
Negative_regulation (prevented) of Localization (excretion) of ADH in urine associated with volume depletion and dehydration and butorphanol
2) Confidence 0.59 Published 1975 Journal Neuroendocrinology Section Abstract Doc Link 1223660 Disease Relevance 0.18 Pain Relevance 0.53
Clonidine, an alpha adrenergic agonist which causes a diuresis in experimental animals, was studied in unanesthetized, conscious Brattleboro rats heterozygous or homozygous for hereditary hypothalamic diabetes insipidus to determine if the diuresis was due to alpha adrenergic inhibition of antidiuretic hormone (ADH) release or to another mechanism of action.
Negative_regulation (inhibition) of Localization (release) of ADH associated with diuresis, diabetes insipidus, agonist and clonidine
3) Confidence 0.59 Published 1980 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7400963 Disease Relevance 0.62 Pain Relevance 0.53
These results suggest that clonidine-induced diuresis is related to inhibition of vasopressin (ADH) secretion.
Negative_regulation (inhibition) of Localization (secretion) of ADH associated with diuresis and clonidine
4) Confidence 0.57 Published 1981 Journal J Pharmacol Section Abstract Doc Link 7289624 Disease Relevance 0.41 Pain Relevance 0.95
It is concluded that, in the anesthetized dog, intraventricular norepinephrine and clonidine decreased ADH release, blood pressure, and heart rate by stimulating alpha-adrenoreceptors.
Negative_regulation (decreased) of Localization (release) of ADH in blood associated with clonidine
5) Confidence 0.52 Published 1981 Journal Endocrinology Section Abstract Doc Link 7215302 Disease Relevance 0.17 Pain Relevance 0.23
Both norepinephrine and clonidine markedly reduced ADH release and lowered arterial blood pressure and heart rate.
Negative_regulation (reduced) of Localization (release) of ADH in heart associated with clonidine
6) Confidence 0.52 Published 1981 Journal Endocrinology Section Abstract Doc Link 7215302 Disease Relevance 0.15 Pain Relevance 0.19
It is concluded that the diuresis in consequence to hypothermia is due both to a decrease in the release of ADH and to a reduction of renal medullary hypertonicity.
Negative_regulation (decrease) of Localization (release) of ADH associated with diuresis and hypothermia
7) Confidence 0.47 Published 1998 Journal Acta Physiol. Scand. Section Abstract Doc Link 9597114 Disease Relevance 0.71 Pain Relevance 0.06
Inhibition of ADH release in the rat by narcotic antagonists.
Negative_regulation (Inhibition) of Localization (release) of ADH associated with antagonist
8) Confidence 0.43 Published 1975 Journal Neuroendocrinology Section Title Doc Link 1223660 Disease Relevance 0.16 Pain Relevance 0.50
Thus, clonidine-induced diuresis does not appear to be due to alpha adrenergic inhibition of ADH release but rather to direct renal effects.
Negative_regulation (inhibition) of Localization (release) of ADH associated with diuresis and clonidine
9) Confidence 0.43 Published 1980 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7400963 Disease Relevance 0.68 Pain Relevance 0.80
Clonidine-induced diuresis was not at least due to the inhibition of ADH release.
Negative_regulation (inhibition) of Localization (release) of ADH associated with diuresis and clonidine
10) Confidence 0.41 Published 1996 Journal Fundam Clin Pharmacol Section Abstract Doc Link 8900500 Disease Relevance 0.66 Pain Relevance 1.20
The increased release of ADH after peripheral administration of isoproterenol was presumably due to the reduction in blood pressure and decreased baroreceptor inhibition of ADH release.
Negative_regulation (inhibition) of Localization (release) of ADH in blood
11) Confidence 0.38 Published 1981 Journal Endocrinology Section Abstract Doc Link 7215302 Disease Relevance 0.15 Pain Relevance 0.15
The increased release of ADH after peripheral administration of isoproterenol was presumably due to the reduction in blood pressure and decreased baroreceptor inhibition of ADH release.
Negative_regulation (decreased) of Localization (release) of ADH in blood
12) Confidence 0.38 Published 1981 Journal Endocrinology Section Abstract Doc Link 7215302 Disease Relevance 0.15 Pain Relevance 0.15
Pretreatment with phenoxybenzamine (100 microgram/kg, iv) completely blocked the effects of norepinephrine on blood pressure and heart rate but only partially (about 50%) inhibited the norepinephrine effect on ADH release.
Negative_regulation (inhibited) of Localization (release) of ADH in blood
13) Confidence 0.38 Published 1981 Journal Endocrinology Section Abstract Doc Link 7215302 Disease Relevance 0.19 Pain Relevance 0.23
The aim of this study was to investigate whether the increased diuresis in consequence of hypothermia is due to a depression of the hypothalamic release of antidiuretic hormone (ADH).
Spec (whether) Negative_regulation (depression) of Localization (release) of ADH associated with diuresis, hypothermia and depression
14) Confidence 0.35 Published 1998 Journal Acta Physiol. Scand. Section Abstract Doc Link 9597114 Disease Relevance 0.37 Pain Relevance 0.09
The increased release of ADH after peripheral administration of isoproterenol was presumably due to the reduction in blood pressure and decreased baroreceptor inhibition of ADH release.
Negative_regulation (decreased) of Localization (release) of ADH in blood
15) Confidence 0.33 Published 1981 Journal Endocrinology Section Abstract Doc Link 7215302 Disease Relevance 0.16 Pain Relevance 0.21
Pretreatment with yohimbine completely blocked the effect of NE on ADH release, and brought about a slight rise in blood pressure and heart rate.
Negative_regulation (blocked) of Localization (release) of ADH in blood associated with pressure and volume under development
16) Confidence 0.26 Published 1984 Journal Endocrinology Section Abstract Doc Link 6323145 Disease Relevance 0.34 Pain Relevance 0.08
Pretreatment with prazosin did not block significantly the effect of NE on blood pressure, heart rate, and ADH release.
Negative_regulation (block) of Localization (release) of ADH in blood
17) Confidence 0.26 Published 1984 Journal Endocrinology Section Abstract Doc Link 6323145 Disease Relevance 0.35 Pain Relevance 0.08
On the other hand, central alpha 2-adrenoceptors might act to reduce ADH release and to depress the cardiovascular system.
Negative_regulation (reduce) of Localization (release) of ADH in cardiovascular system
18) Confidence 0.26 Published 1984 Journal Endocrinology Section Abstract Doc Link 6323145 Disease Relevance 0.28 Pain Relevance 0.06
The results suggest that clonidine increases V through inhibition of ADH release, possibly via an indirect pathway mediated by the drug's alpha-adrenergic on the circulation.
Spec (possibly) Negative_regulation (inhibition) of Localization (release) of ADH associated with clonidine
19) Confidence 0.14 Published 1975 Journal Kidney Int. Section Abstract Doc Link 1167185 Disease Relevance 0 Pain Relevance 0.37
Ang II antagonist given intracerebroventricularly neither affected ADH release and the cardiovascular system in 0.15 M NaCl nor inhibited ADH release in response to osmotic stimulation.
Negative_regulation (inhibited) of Localization (release) of ADH in cardiovascular system associated with antagonist
20) Confidence 0.06 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3014365 Disease Relevance 0.23 Pain Relevance 0.05

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