INT44408

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Context Info
Confidence 0.40
First Reported 1984
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 1.61
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
tympanic cavity 1
brush 1
reticulum 1
Sis (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 20 100.00 Very High Very High Very High
corticosteroid 7 96.16 Very High Very High Very High
fibrosis 31 88.72 High High
Bile 54 83.88 Quite High
abdominal pain 2 77.56 Quite High
Clonidine 1 75.00 Quite High
sodium channel 6 5.00 Very Low Very Low Very Low
cINOD 5 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shoulder Impingement Syndrome 26 100.00 Very High Very High Very High
Pain 13 100.00 Very High Very High Very High
Recurrence 9 100.00 Very High Very High Very High
Lactose Intolerance 1 92.76 High High
Ganglion Cysts 1 92.36 High High
Fibrosis 1 88.72 High High
Abdominal Pain 2 77.56 Quite High
Diarrhoea 3 76.80 Quite High
Targeted Disruption 9 50.00 Quite Low
Cystic Fibrosis 30 39.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was found that i) SIS similar to pain are caused by electrical stimulation of the mucous membranes and periosteum of the tympanic cavity; ii) the high-frequency SIS seemed to be due to non-physiological electrical stimulation of the basal ganglion cells; and iii) the reason for non-stimulation is probably damaged electrodes and fibrosis around the electrode.
Positive_regulation (caused) of SIS in tympanic cavity associated with ganglion cysts, fibrosis and pain
1) Confidence 0.40 Published 1993 Journal Acta Otolaryngol. Section Abstract Doc Link 8266783 Disease Relevance 0.37 Pain Relevance 0.23
Patients are eligible for inclusion when experiencing a recurrence of SIS within one year after a first episode of SIS which was successfully treated with a subacromial corticosteroid injection.
Positive_regulation (recurrence) of SIS associated with corticosteroid, shoulder impingement syndrome and recurrence
2) Confidence 0.28 Published 2007 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC1821022 Disease Relevance 0.84 Pain Relevance 0.05
SIS induces significantly less discomfort than office hysteroscopy and should therefore be considered the method of choice.


Positive_regulation (induces) of SIS
3) Confidence 0.12 Published 2008 Journal BJOG Section Body Doc Link 18715407 Disease Relevance 0 Pain Relevance 0
Prior to use for Western blotting, brush border membrane vesicle suspensions were tested for enrichment of brush border enzymes and showed a 4 – 5-fold increase of alkaline phosphatase and a 10 – 11-fold increase in alpha-glucosidase activity using standard methods [19].
Positive_regulation (increase) of alpha-glucosidase in brush
4) Confidence 0.12 Published 2001 Journal BMC Gastroenterol Section Body Doc Link PMC59644 Disease Relevance 0 Pain Relevance 0
The activities of neutral alpha-glucosidase (endoplasmic reticulum) or acid phosphatase and N-acetyl-beta-D-glucosaminidase (lysosomes) were not affected by mannoheptulose. 2-Deoxyglucose (5 mmol/l), another glucose analogue, did not increase insulin secretion or acid alpha-glucosidase activity at low glucose.
Neg (not) Positive_regulation (increase) of alpha-glucosidase in reticulum
5) Confidence 0.04 Published 1993 Journal Pharmacology Section Abstract Doc Link 8441762 Disease Relevance 0 Pain Relevance 0.07
Duodenal disaccharidase levels in all patients were within the normal ranges, but in eight patients the lactase-sucrase ratio was greatly elevated (0.80 +/- 0.36; normal less than 0.45).
Positive_regulation (elevated) of lactase-sucrase
6) Confidence 0.03 Published 1984 Journal Pediatrics Section Abstract Doc Link 6431389 Disease Relevance 0.40 Pain Relevance 0.19

General Comments

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