INT44424

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Context Info
Confidence 0.58
First Reported 1981
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 1.70
Pain Relevance 2.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (BRD2)
Anatomy Link Frequency
pituitary 1
T24 1
BRD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 4 99.98 Very High Very High Very High
narcan 12 99.78 Very High Very High Very High
Enkephalin 8 99.78 Very High Very High Very High
Analgesic 2 98.78 Very High Very High Very High
opiate 3 98.58 Very High Very High Very High
butorphanol 3 98.04 Very High Very High Very High
cINOD 1 94.08 High High
agonist 1 92.56 High High
antagonist 1 90.16 High High
imagery 1 88.72 High High
Disease Link Frequency Relevance Heat
Stress 1 98.42 Very High Very High Very High
Brain Injury 2 96.68 Very High Very High Very High
Bladder Cancer 2 96.44 Very High Very High Very High
INFLAMMATION 1 93.84 High High
Endometriosis (extended) 4 92.20 High High
Diabetes Insipidus 1 86.84 High High
Injury 2 84.28 Quite High
Cyst 1 78.16 Quite High
Hypopituitarism 3 76.92 Quite High
Anxiety Disorder 8 70.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of the present study was to determine whether sulindac affects arylamine N-acetyltransferase (NAT) activity and gene expression and DNA-2-aminofluorene adduct formation in the T24 human bladder tumor cell line.
Spec (whether) Regulation (affects) of NAT in T24 associated with bladder cancer
1) Confidence 0.58 Published 2001 Journal Urol. Res. Section Abstract Doc Link 11828994 Disease Relevance 0.27 Pain Relevance 0.09
However, the LHRH-induced rise in LH and FSH in young male volunteers was unaffected by pretreatment with a high-dose DAMME infusion.
Neg (unaffected) Regulation (unaffected) of FSH
2) Confidence 0.41 Published 1981 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 6784982 Disease Relevance 0.16 Pain Relevance 0.61
The opioid control of LH and FSH release: effects of a met-enkephalin analogue and naloxone.
Regulation (control) of FSH associated with narcan, enkephalin and opioid
3) Confidence 0.41 Published 1981 Journal Clin. Endocrinol. (Oxf) Section Title Doc Link 6784982 Disease Relevance 0.16 Pain Relevance 0.80
The i.m. administration to 6 healthy adult male volunteers of 2 mg butorphanol, a potent synthetic opiate analgesic, resulted in a significant rise in serum PRL level, without affecting GH, LH, FSH, TSH or cortisol secretion.
Neg (without) Regulation (affecting) of FSH associated with analgesic, butorphanol and opiate
4) Confidence 0.22 Published 1984 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 6432552 Disease Relevance 0 Pain Relevance 0.82
Three months after the head injury, the hormonal evaluation of the hypothalamic-pituitary axis by means of insulin stress test with the simultaneous administration of TRH and GnRH resulted in reduced responses of GH, cortisol, TSH, FSH, and LH with low baseline serum concentrations of free T4 and testosterone.
Regulation (responses) of FSH in pituitary associated with stress and brain injury
5) Confidence 0.14 Published 1996 Journal J. Endocrinol. Invest. Section Abstract Doc Link 8796342 Disease Relevance 0.81 Pain Relevance 0.10
However, the need for further evaluation of the Guidelines and NAT: PD-C to assess patients and their caregivers at multiple time points and determine the responsiveness of the NAT: PD-C to change over time has been acknowledged.
Spec (determine) Regulation (responsiveness) of NAT
6) Confidence 0.14 Published 2010 Journal BMC Palliat Care Section Body Doc Link PMC2820447 Disease Relevance 0.31 Pain Relevance 0.33

General Comments

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