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Context Info
Confidence 0.50
First Reported 1984
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.78
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein modification process (PLOD1) signal transduction (GNRH1) extracellular space (GNRH1)
extracellular region (GNRH1) endoplasmic reticulum (PLOD1) cell-cell signaling (GNRH1)
Anatomy Link Frequency
ovary 2
GNRH1 (Homo sapiens)
PLOD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 1 98.36 Very High Very High Very High
narcan 5 97.02 Very High Very High Very High
Calcium channel 1 95.44 Very High Very High Very High
Opioid 1 87.52 High High
aspirin 6 82.92 Quite High
antagonist 4 82.84 Quite High
opiate 1 66.84 Quite High
Somatostatin 1 59.72 Quite High
depression 3 51.60 Quite High
Endogenous opioid 1 49.48 Quite Low
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 1 98.36 Very High Very High Very High
Thyroid Disease 1 92.96 High High
Stress 85 92.88 High High
Coronary Artery Disease 1 86.76 High High
Reprotox - General 1 2 56.00 Quite High
Anxiety Disorder 4 52.56 Quite High
Depression 5 51.60 Quite High
Appetite Loss 2 50.64 Quite High
Reprotox - General 2 1 44.96 Quite Low
Cushing's Syndrome /


1 43.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, the drug induced a significant reduction of LH response to naloxone, assessed as the mean integrated area under the curve, from 1666.5 +/- 116 to 1197.5 +/- 98 mUI/mL per min (P < 0.05), whereas it did not influence GnRH-induced LH release.
GnRH Positive_regulation (induced) of Localization (release) of LH associated with narcan
1) Confidence 0.50 Published 1996 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8626832 Disease Relevance 0 Pain Relevance 0.54
To see if a similar effect could be detected after their chronic administration, we studied the basal, TRH- and LHRH-stimulated TSH, PRL, LH and FSH release in 18 male subjects with chronic stable angina before and on the 30th day of oral treatment with verapamil (n = 8;80 mg three times a day) or with nifedipine (n = 10; 10 mg three times a day).
LHRH-stimulated Positive_regulation (stimulated) of Localization (release) of LH associated with angina
2) Confidence 0.06 Published 1984 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 6434209 Disease Relevance 0.19 Pain Relevance 0.26
GnRH stimulates pituitary follicle stimulating and LH secretion and, subsequently, estradiol and progesterone secretion by the ovary.
GnRH Positive_regulation (stimulates) of Localization (secretion) of LH in ovary
3) Confidence 0.05 Published 2006 Journal Chiropr Osteopat Section Body Doc Link PMC1629015 Disease Relevance 0.60 Pain Relevance 0.06

General Comments

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