INT44466

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.75
First Reported 1984
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 1.32
Pain Relevance 2.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Ugt2b7) molecular_function (Ugt2b7) cellular_component (Ugt2b7)
biological_process (Ugt2b7)
Anatomy Link Frequency
liver 2
2B7 2
spinal 1
peripheral nerve 1
Ugt2b7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
diclofenac 3 99.50 Very High Very High Very High
Morphine 10 97.68 Very High Very High Very High
cINOD 2 97.64 Very High Very High Very High
Peripheral nerve injury 4 97.48 Very High Very High Very High
Central nervous system 8 96.92 Very High Very High Very High
Neuropathic pain 4 95.08 Very High Very High Very High
Spinal cord 2 92.16 High High
Bile 1 55.52 Quite High
Disease Link Frequency Relevance Heat
Hepatotoxicity 3 99.96 Very High Very High Very High
Neuropathic Pain 6 99.24 Very High Very High Very High
Genetic Predisposition To Disease 1 99.22 Very High Very High Very High
Nervous System Injury 4 97.04 Very High Very High Very High
INFLAMMATION 2 96.92 Very High Very High Very High
Jaundice 1 91.20 High High
Injury 2 5.00 Very Low Very Low Very Low
Autoimmune Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
V79 (Chinese hamster lung fibroblast) cell lines expressing a functional recombinant phenobarbital-inducible rat liver UDP-glucuronosyltransferase (UGT), i.e., UGT2B1, were established.
Gene_expression (expressing) of UGT in liver
1) Confidence 0.75 Published 1994 Journal Mol. Pharmacol. Section Abstract Doc Link 8302279 Disease Relevance 0.05 Pain Relevance 0.16
Kinetic properties of UDP-glucuronosyltransferase(S) in different membranes of rat liver cells.
Gene_expression (properties) of UDP-glucuronosyltransferase in liver
2) Confidence 0.65 Published 1984 Journal Xenobiotica Section Title Doc Link 6438924 Disease Relevance 0 Pain Relevance 0.17
Effects of cytochrome P450 isoforms, CYP1A2, CYP2C9 and CYP3A4, on the catalytic activity of UDP-glucuronosyltransferase 2B7 (UGT2B7) expressed in COS cell microsomal membranes were investigated using morphine as a substrate.
Gene_expression (expressed) of UGT2B7 in 2B7 associated with morphine
3) Confidence 0.47 Published 2005 Journal Biol. Pharm. Bull. Section Abstract Doc Link 16204972 Disease Relevance 0 Pain Relevance 0.25
Effects of cytochrome P450 isoforms, CYP1A2, CYP2C9 and CYP3A4, on the catalytic activity of UDP-glucuronosyltransferase 2B7 (UGT2B7) expressed in COS cell microsomal membranes were investigated using morphine as a substrate.
Gene_expression (expressed) of UDP-glucuronosyltransferase 2B7 in 2B7 associated with morphine
4) Confidence 0.47 Published 2005 Journal Biol. Pharm. Bull. Section Abstract Doc Link 16204972 Disease Relevance 0 Pain Relevance 0.25
Genetic susceptibility to diclofenac-induced hepatotoxicity: contribution of UGT2B7, CYP2C8, and ABCC2 genotypes.
Gene_expression (contribution) of UGT2B7 associated with genetic predisposition to disease, hepatotoxicity and diclofenac
5) Confidence 0.26 Published 2007 Journal Gastroenterology Section Title Doc Link 17241877 Disease Relevance 0.57 Pain Relevance 0.24
In the present study, we determined the lumbar spinal expression of the co-stimulatory molecules B7.1 and B7.2 in a rat model of neuropathy.
Gene_expression (expression) of B7.2 in spinal associated with neuropathic pain
6) Confidence 0.19 Published 2004 Journal J. Neuroimmunol. Section Abstract Doc Link 14698851 Disease Relevance 0.34 Pain Relevance 0.47
Presence of spinal B7.2 (CD86) but not B7.1 (CD80) co-stimulatory molecules following peripheral nerve injury: role of nondestructive immunity in neuropathic pain.
Gene_expression (Presence) of B7.2 in peripheral nerve associated with nervous system injury, neuropathic pain and peripheral nerve injury
7) Confidence 0.16 Published 2004 Journal J. Neuroimmunol. Section Title Doc Link 14698851 Disease Relevance 0.35 Pain Relevance 0.46

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox