INT44487

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Context Info
Confidence 0.13
First Reported 1984
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.06
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Cyp51)
Cyp51 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
lidocaine 1 99.80 Very High Very High Very High
Morphine 1 95.32 Very High Very High Very High
Paracetamol 17 89.48 High High
depression 1 50.00 Quite Low
Disease Link Frequency Relevance Heat
Hepatotoxicity 1 58.88 Quite High
Depression 1 50.00 Quite Low
Injury 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
P-nitroanisole-O-demethylase activity was reduced while hepatic and serum reduced glutathione levels remained basically unaltered.
Negative_regulation (reduced) of P-nitroanisole-O-demethylase
1) Confidence 0.13 Published 1984 Journal Eur J Drug Metab Pharmacokinet Section Abstract Doc Link 6442703 Disease Relevance 0 Pain Relevance 0.10
FK-506 non-competitively inhibited the aniline p-hydroxylase, p-nitroanisole O-demethylase and lidocaine N-deethylase activities of cytochrome P-450-linked monooxygenase systems, these activities being mainly catalyzed by cytochromes P-450 CYP2E1, CYP2C11 and CYP3A4, respectively, and the Ki values of the activities for FK-506 were determined to be 605, 491 and 97 microM, respectively.
Negative_regulation (inhibited) of p-nitroanisole O-demethylase associated with lidocaine
2) Confidence 0.09 Published 1997 Journal Int. J. Biochem. Cell Biol. Section Abstract Doc Link 9304807 Disease Relevance 0 Pain Relevance 0.10
Parenteral nutrition decreased microsomal cytochrome P450 concentration (47%), p-nitroanisole demethylase activity (68%) and p-nitrophenol UDP-glucuronosyltransferase activity (58%).
Negative_regulation (decreased) of p-nitroanisole demethylase
3) Confidence 0.08 Published 1995 Journal JPEN J Parenter Enteral Nutr Section Body Doc Link 8523630 Disease Relevance 0 Pain Relevance 0
Likewise, CCl(4) treatment reduced the microsomal p-nitrophenol hydroxylase and p-nitroanisole O-demethylase activities to less than one third of control.
Negative_regulation (reduced) of p-nitroanisole O-demethylase
4) Confidence 0.00 Published 2006 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 16445600 Disease Relevance 0.06 Pain Relevance 1.14

General Comments

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