INT4449

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Context Info
Confidence 0.55
First Reported 1975
Last Reported 2011
Negated 4
Speculated 3
Reported most in Abstract
Documents 179
Total Number 183
Disease Relevance 40.26
Pain Relevance 37.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
heart 7
plasma 6
urine 3
brain 3
neuronal 3
NA (Homo sapiens)
Pain Link Frequency Relevance Heat
Action potential 378 100.00 Very High Very High Very High
tetrodotoxin 376 100.00 Very High Very High Very High
noradrenaline 58 100.00 Very High Very High Very High
Sciatic nerve 12 99.88 Very High Very High Very High
ischemia 325 99.84 Very High Very High Very High
Spinal cord 14 99.84 Very High Very High Very High
Sumatriptan 5 99.84 Very High Very High Very High
nMDA receptor 157 99.80 Very High Very High Very High
adenocard 57 99.80 Very High Very High Very High
addiction 174 99.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypoxia 407 100.00 Very High Very High Very High
Alkalosis 66 99.98 Very High Very High Very High
Cv Unclassified Under Development 162 99.84 Very High Very High Very High
Natriuresis 67 99.72 Very High Very High Very High
Death 110 99.66 Very High Very High Very High
Coronary Artery Disease 21 99.64 Very High Very High Very High
Stress 210 99.54 Very High Very High Very High
Critical Illness 27 99.36 Very High Very High Very High
Cancer 55 99.24 Very High Very High Very High
Acidosis 29 99.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The consequent increases in intracellular Na+ concentration ([Na+]i) and/or [K+]o stimulate Na+,K+-ATPase activity, which in turn stimulates energy metabolism and rates of glucose utilization (CMR[glc]) in neurons.
Positive_regulation (stimulate) of Na in neurons
1) Confidence 0.55 Published 1997 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 9466713 Disease Relevance 0 Pain Relevance 0
These results indicate that elevation of Na+i is a late consequence of energy failure in the cerebral cortex.
Positive_regulation (elevation) of Na in cerebral cortex associated with cerebral cortex
2) Confidence 0.44 Published 1993 Journal Neuroreport Section Abstract Doc Link 8453050 Disease Relevance 0.48 Pain Relevance 0.14
Currently, we do not have an explanation for the increase in amplitude and frequency of Na+ currents in human Müller cells under pathological conditions.
Positive_regulation (e in amp) of Na
3) Confidence 0.39 Published 1996 Journal Eur. J. Neurosci. Section Abstract Doc Link 8996816 Disease Relevance 0.14 Pain Relevance 0.18
The number of Na+ pump sites identified by [3H]ouabain binding binding declined with decreasing levels of Na+ in the medium in a time-dependent manner over 48 h, with a concomitant increase in cellular Na+ content.
Positive_regulation (increase) of Na
4) Confidence 0.39 Published 1986 Journal Am. J. Physiol. Section Abstract Doc Link 3942206 Disease Relevance 0 Pain Relevance 0.10
Results of the present study suggest that during anoxia, Na+ enters axons mainly through voltage-gated Na+ channels and that subsequent increases in axoplasmic Na+ are functionally coupled to extra-axonal Ca2+ import.
Positive_regulation (increases) of Na associated with hypoxia
5) Confidence 0.39 Published 1998 Journal Neuroscience Section Abstract Doc Link 9483500 Disease Relevance 0.35 Pain Relevance 0.10
These results suggest that monensin increases the release of ACh at least in part by increasing [Ca2+]i, resulting from the increase in the Na+ influx through tetrodotoxin-insensitive mechanisms in rat cerebrocortical synaptosomes.
Positive_regulation (increase) of Na associated with tetrodotoxin
6) Confidence 0.39 Published 1991 Journal J. Neurochem. Section Abstract Doc Link 1895105 Disease Relevance 0 Pain Relevance 0.19
In the presence of ouabain, both diuretics decreased net intracellular accumulation of Na+, but caused no change in K+ content.
Positive_regulation (accumulation) of Na
7) Confidence 0.39 Published 1996 Journal Acta Physiol. Scand. Section Abstract Doc Link 8899058 Disease Relevance 0 Pain Relevance 0.07
Similarly, the administration of U-50,488 H (15 mg/kg i.p.) produced an increase in the MHPG and MHPG/NA ratio without any changes in the NA content.
Positive_regulation (increase) of NA associated with noradrenaline
8) Confidence 0.38 Published 1999 Journal Neuropeptides Section Abstract Doc Link 10657482 Disease Relevance 0 Pain Relevance 0.77
Aconitine potentiated the contractile response of the guinea-pig vas deferens and increased the tissue Na and Ca content.
Positive_regulation (increased) of Na in vas deferens
9) Confidence 0.38 Published 1987 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 2884304 Disease Relevance 0 Pain Relevance 0.09
To study the influence of (+/-)-kavain on non stimulated synaptosomes, an increase in [Na+]i was induced by 200 mumol/l ouabain, which enhanced [Na+]i hyperbolically with an initial rate of 18.4 mmol Na+/l min.
Positive_regulation (induced) of Na
10) Confidence 0.38 Published 1995 Journal Neuropharmacology Section Abstract Doc Link 8532183 Disease Relevance 0 Pain Relevance 0.09
Delayed increase in intracellular Na+ in cerebral cortical slices during severe hypoxia as measured by double quantum filtered 23Na+ NMR.
Positive_regulation (increase) of Na associated with hypoxia
11) Confidence 0.38 Published 1993 Journal Neuroreport Section Title Doc Link 8453050 Disease Relevance 0.34 Pain Relevance 0
Tissue Na, but not Ca, accumulation was also detected in the ischemic heart, and tissue Na and Ca accumulation was observed in the reperfused heart, which suggests that sodium overload occurs during ischemia, followed by sodium and calcium overload during reperfusion.
Neg (not) Positive_regulation (accumulation) of Na in heart associated with ischemia
12) Confidence 0.38 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7791114 Disease Relevance 0.28 Pain Relevance 0.60
We conclude that: (1) the activation of voltage-gated Na+ channels is involved in the triggering of AD; (2) there may be a critical level of energy depletion when AD occurs and different mechanisms may underlie AD during hypoxia, compared to O2 and glucose deprivation.
Positive_regulation (activation) of Na associated with hypoxia
13) Confidence 0.38 Published 1999 Journal Neurosci. Lett. Section Abstract Doc Link 10554980 Disease Relevance 0.27 Pain Relevance 0.22
In model B, addition of TX to ORS increased water, Na+, K+, and glucose absorption, compared with rats perfused without TX.
Positive_regulation (increased) of Na
14) Confidence 0.38 Published 1999 Journal Pediatr. Res. Section Abstract Doc Link 10088661 Disease Relevance 0.46 Pain Relevance 0.07
Tissue Na, but not Ca, accumulation was also detected in the ischemic heart, and tissue Na and Ca accumulation was observed in the reperfused heart, which suggests that sodium overload occurs during ischemia, followed by sodium and calcium overload during reperfusion.
Positive_regulation (accumulation) of Na in heart associated with ischemia
15) Confidence 0.38 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7791114 Disease Relevance 0.33 Pain Relevance 0.62
To further elucidate the role of the Na+ channel in the ischemic accumulation of intracellular Na+ (Na+i), 200 microM lidocaine was included in the perfusate for 5 min prior to 30 min of ischemia in isolated rat hearts paced at 5 Hz.
Positive_regulation (accumulation) of Na in hearts associated with ischemia and lidocaine
16) Confidence 0.38 Published 1997 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 9040024 Disease Relevance 0.23 Pain Relevance 0.34
The role of the Na+ channel in the accumulation of intracellular Na+ during myocardial ischemia: consequences for post-ischemic recovery.
Positive_regulation (accumulation) of Na associated with coronary artery disease and ischemia
17) Confidence 0.38 Published 1997 Journal J. Mol. Cell. Cardiol. Section Title Doc Link 9040024 Disease Relevance 0.44 Pain Relevance 0.70
To further elucidate the role of the Na+ channel in the ischemic accumulation of intracellular Na+ (Na+i), 200 microM lidocaine was included in the perfusate for 5 min prior to 30 min of ischemia in isolated rat hearts paced at 5 Hz.
Positive_regulation (accumulation) of Na in hearts associated with ischemia and lidocaine
18) Confidence 0.38 Published 1997 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 9040024 Disease Relevance 0.23 Pain Relevance 0.34
Consistent with this notion, Na+ spikes could be induced in spinal cord astrocytes in culture when IIR was experimentally blocked by 10 microM Ba2+, suggesting that the absence of IIR in astrocytoma cells is primarily responsible for the unusual spiking behavior seen in these glial tumor cells.
Positive_regulation (induced) of Na in astrocytes associated with anaplastic astrocytoma, glioma and spinal cord
19) Confidence 0.38 Published 1998 Journal J. Neurophysiol. Section Abstract Doc Link 9582244 Disease Relevance 0.70 Pain Relevance 0.09
Our findings suggest that activation of amiloride-sensitive and voltage-gated Na+ channels would be an important step to allow an adequate influx of Na+ and maintain a sustained high Ca2+ level during T cell activation.
Positive_regulation (activation) of Na in T cell
20) Confidence 0.38 Published 2000 Journal J. Immunol. Section Abstract Doc Link 10861038 Disease Relevance 0 Pain Relevance 0.09

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