INT44529

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Context Info
Confidence 0.43
First Reported 1981
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 7.98
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pdgfb) cytoplasm (Pdgfb)
Anatomy Link Frequency
platelet 2
aorta 1
brain 1
pericyte 1
fibroblasts 1
Pdgfb (Mus musculus)
Pain Link Frequency Relevance Heat
Angina 12 99.38 Very High Very High Very High
fibrosis 83 94.64 High High
chemokine 34 89.44 High High
cytokine 22 84.16 Quite High
Inflammatory response 30 83.40 Quite High
Inflammation 69 82.72 Quite High
cva 7 66.76 Quite High
ischemia 49 50.00 Quite Low
beta blocker 1 48.40 Quite Low
metalloproteinase 6 45.32 Quite Low
Disease Link Frequency Relevance Heat
Fibrosis 79 100.00 Very High Very High Very High
Diabetes Mellitus 41 99.98 Very High Very High Very High
Cv General 3 Under Development 11 99.38 Very High Very High Very High
Hyperplasia 3 99.00 Very High Very High Very High
Cancer 320 98.84 Very High Very High Very High
Increased Venous Pressure Under Development 40 98.16 Very High Very High Very High
Injury 6 96.24 Very High Very High Very High
Adhesions 14 92.04 High High
Lung Injury 2 91.32 High High
Pulmonary Fibrosis 18 90.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PDGF-BB-expression significantly increased the pericyte density in B16 tumors (0.8–1.0 cm3) grown in wild type mice (p < 0.001) (Fig. 1D).
Positive_regulation (increased) of PDGF-BB in pericyte associated with cancer
1) Confidence 0.43 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2234427 Disease Relevance 0.93 Pain Relevance 0
The average vessel surface, defined as the total vessel area divided by the number of vessels, was increased in PDGF-BB-expressing compared to wild type B16 tumors, grown in wild type (p < 0.0001), as well as D849N-mutant mice (p < 0.01) (Fig. 1B).
Positive_regulation (increased) of PDGF-BB in vessels associated with cancer
2) Confidence 0.43 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2234427 Disease Relevance 1.05 Pain Relevance 0
Cultured, otherwise normal Trp53-null brain cells show an increased survival and proliferation in vitro, coupled with upregulation and activation of Pdgf-receptors [134].
Positive_regulation (upregulation) of Pdgf in brain
3) Confidence 0.27 Published 2011 Journal Journal of Oncology Section Body Doc Link PMC3010739 Disease Relevance 0.48 Pain Relevance 0
In 19 patients with unstable angina pectoris at rest, plasma levels of the platelet-derived proteins beta-thromboglobulin and platelet factor 4 were significantly elevated in blood samples obtained during or within 4 hours after episodes of angina, but were usually normal during quiescent intervals.
Positive_regulation (elevated) of platelet-derived proteins beta-thromboglobulin in platelet associated with angina
4) Confidence 0.21 Published 1981 Journal Circulation Section Abstract Doc Link 6450001 Disease Relevance 0.80 Pain Relevance 0.74
In the current study, we showed that treatment of fat grafts with EPO increased VEGF, bFGF, IGF-1, PDGF-BB and MMP-2 contents, as well as MVD in the fat grafts.
Positive_regulation (increased) of PDGF in fat
5) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981551 Disease Relevance 0.31 Pain Relevance 0
EPO induced a dose-dependent increase in the expression levels of bFGF, IGF-1, PDGF-BB, MMP-2, PKB, and phosphoPKB (Figure 3B).
Positive_regulation (increase) of PDGF
6) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981551 Disease Relevance 0.30 Pain Relevance 0.06
Profibrogenic growth factors, including platelet-derived growth factor (PDGF) and its receptor, are elevated in rats exposed to V2O5 [15].
Positive_regulation (elevated) of PDGF in platelet
7) Confidence 0.10 Published 2010 Journal Respir Res Section Body Doc Link PMC2841591 Disease Relevance 1.74 Pain Relevance 0.31
For example, gene expression profiling of normal human lung fibroblasts exposed to V2O5 in culture show increased levels of pro-fibrotic and angiogenic growth factors (PDGF, CTGF, HB-EGF, VEGF) as well as protective IFNs [20].
Positive_regulation (increased) of PDGF in fibroblasts associated with fibrosis
8) Confidence 0.10 Published 2010 Journal Respir Res Section Body Doc Link PMC2841591 Disease Relevance 0.87 Pain Relevance 0.21
Irbesartan but not amlodipine treatment attenuated the development of atherosclerosis, collagen content, cellular proliferation, and macrophage infiltration as well as diabetes-induced AT-1 receptor, PDGF-B, MCP-1, and VCAM-1 overexpression in the aorta, despite similar blood pressure reductions by both treatments (Candido et al 2004).
Positive_regulation (induced) of PDGF-B in aorta associated with diabetes mellitus, increased venous pressure under development and hyperplasia
9) Confidence 0.09 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464748 Disease Relevance 0.98 Pain Relevance 0.04
Thus, deregulated activation of PDGF-B is the critical molecular event in DFSP (see Figure 1).
Positive_regulation (activation) of PDGF-B
10) Confidence 0.07 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721290 Disease Relevance 0.51 Pain Relevance 0
Upregulated production of angiogenic factors including PDGF, EGF, and VEGF have been described both in the mouse and human endometrium [55,56].
Positive_regulation (Upregulated) of PDGF in endometrium
11) Confidence 0.06 Published 2008 Journal J Transl Med Section Body Doc Link PMC2533293 Disease Relevance 0 Pain Relevance 0

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