INT44537

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Context Info
Confidence 0.69
First Reported 1981
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 7
Total Number 11
Disease Relevance 2.62
Pain Relevance 7.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Comt) methyltransferase activity (Comt) plasma membrane (Comt)
Anatomy Link Frequency
striatum 2
nucleus accumbens 1
prefrontal 1
Comt (Mus musculus)
Pain Link Frequency Relevance Heat
Catechol-O-methyltransferase 285 100.00 Very High Very High Very High
Dopamine 128 99.54 Very High Very High Very High
Morphine 161 99.00 Very High Very High Very High
monoamine 14 98.84 Very High Very High Very High
analgesia 16 98.32 Very High Very High Very High
withdrawal 8 98.20 Very High Very High Very High
tolerance 2 97.60 Very High Very High Very High
Nucleus accumbens 97 94.68 High High
Hippocampus 48 90.44 High High
Catecholamine 22 90.16 High High
Disease Link Frequency Relevance Heat
Stress 15 99.48 Very High Very High Very High
Nociception 3 96.36 Very High Very High Very High
Sprains And Strains 534 95.52 Very High Very High Very High
Targeted Disruption 3 88.80 High High
Urological Neuroanatomy 30 78.40 Quite High
Disease 20 54.88 Quite High
Cognitive Disorder 30 54.52 Quite High
Pain 17 50.36 Quite High
Depression 15 5.00 Very Low Very Low Very Low
Drug Dependence 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this case, each copy of the D2 (D) allele increases Comt mRNA signal by a factor of two (Fig. 1B and www.genenetwork.org).
Positive_regulation (increases) of Comt
1) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.29 Pain Relevance 0
An increase in total COMT could be associated with higher enzymatic activity and previous research has demonstrated significantly higher COMT activity in the nucleus accumbens and prefrontal cortex of the B6 strain compared to D2 [10].
Positive_regulation (increase) of COMT in nucleus accumbens associated with nucleus accumbens, catechol-o-methyltransferase and sprains and strains
2) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.15 Pain Relevance 0.35
Elevation of dopamine would be inhibited by increased activity of Comt.
Positive_regulation (increased) of Comt associated with catechol-o-methyltransferase and dopamine
3) Confidence 0.58 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1851712 Disease Relevance 0.14 Pain Relevance 1.00
Alternatively, elevated Comt levels may lead to a hypo-dopamine state which drug taking might alleviate.
Positive_regulation (elevated) of Comt associated with catechol-o-methyltransferase and dopamine
4) Confidence 0.58 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1851712 Disease Relevance 0.07 Pain Relevance 0.95
Pertinent results obtained are delineated below: 1) DFZ at 10(-4) M inhibited the monoamine oxidase (MAO) activity to some extent although it had no activity on catechol-O-methyltransferase (COMT) at 10(-6) -10(-4) M. 2) DFZ significantly enhanced the DA accumulating activity of pargyline in the striatum. 3) DFZ inhibited the binding of 3H-DA to synaptic membrane by 25% at 10(-4) M in the striatum. 4) DFZ inhibited the DA uptake by 50% at 10(-4) M though the activity was somewhat weaker than imipramine or cocaine on the striatum. 5) DFZ inhibited the DA release due to high K+ concentration in striatal slices at 10(-4) -5x10(-4) M.
Neg (no) Positive_regulation (activity) of catechol-O-methyltransferase in striatum associated with catechol-o-methyltransferase, dopamine, cocaine and monoamine
5) Confidence 0.49 Published 1981 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 6454942 Disease Relevance 0 Pain Relevance 0.86
Pertinent results obtained are delineated below: 1) DFZ at 10(-4) M inhibited the monoamine oxidase (MAO) activity to some extent although it had no activity on catechol-O-methyltransferase (COMT) at 10(-6) -10(-4) M. 2) DFZ significantly enhanced the DA accumulating activity of pargyline in the striatum. 3) DFZ inhibited the binding of 3H-DA to synaptic membrane by 25% at 10(-4) M in the striatum. 4) DFZ inhibited the DA uptake by 50% at 10(-4) M though the activity was somewhat weaker than imipramine or cocaine on the striatum. 5) DFZ inhibited the DA release due to high K+ concentration in striatal slices at 10(-4) -5x10(-4) M.
Neg (no) Positive_regulation (activity) of COMT in striatum associated with catechol-o-methyltransferase, dopamine, cocaine and monoamine
6) Confidence 0.49 Published 1981 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 6454942 Disease Relevance 0 Pain Relevance 0.86
Our findings show, for the first time, the importance of COMT activity in stress- and morphine-induced analgesia in mice.
Positive_regulation (importance) of COMT associated with stress, catechol-o-methyltransferase, analgesia and morphine
7) Confidence 0.47 Published 2008 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 18834357 Disease Relevance 0.85 Pain Relevance 2.23
Collectively, these diverse mapping data sets demonstrate that expression of Comt is strongly cis-regulated and is caused by sequence variation in or around Comt itself.
Positive_regulation (caused) of Comt
8) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.46 Pain Relevance 0.03
Impact of Comt gene sequence variation on downstream biological functions
Positive_regulation (variation) of Comt
9) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.38 Pain Relevance 0.17
We, therefore, can hypothesize that animals, or humans, with elevated Comt levels would experience reduced rewarding effects to drugs of abuse, while animals or humans with decreased levels of Comt may be more sensitive to certain drugs of abuse and perhaps even find them aversive.
Positive_regulation (elevated) of Comt associated with catechol-o-methyltransferase
10) Confidence 0.42 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1851712 Disease Relevance 0.13 Pain Relevance 0.98
An increase in total COMT could be associated with higher enzymatic activity and previous research has demonstrated significantly higher COMT activity in the nucleus accumbens and prefrontal cortex of the B6 strain compared to D2 [10].
Positive_regulation (increase) of COMT in prefrontal associated with nucleus accumbens, catechol-o-methyltransferase and sprains and strains
11) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.15 Pain Relevance 0.35

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