INT44544

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Context Info
Confidence 0.76
First Reported 1981
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 10.28
Pain Relevance 2.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ENOPH1) small molecule metabolic process (ENOPH1) nucleus (ENOPH1)
cellular nitrogen compound metabolic process (ENOPH1) cellular_component (ENOPH1) cytoplasm (ENOPH1)
Anatomy Link Frequency
stroma 2
fat cells 1
basal layer 1
ENOPH1 (Homo sapiens)
ENOPH1 - A306V (1)
Pain Link Frequency Relevance Heat
endometriosis 504 99.92 Very High Very High Very High
addiction 3 97.72 Very High Very High Very High
methadone 4 94.56 High High
rheumatoid arthritis 139 94.40 High High
Osteoarthritis 98 93.76 High High
Chronic pancreatitis 1 93.56 High High
Leflunomide 10 70.60 Quite High
cINOD 13 70.04 Quite High
Inflammation 186 69.52 Quite High
depression 12 69.36 Quite High
Disease Link Frequency Relevance Heat
Endometriosis 672 99.92 Very High Very High Very High
Reprotox - General 2 2 99.76 Very High Very High Very High
Cancer 139 99.52 Very High Very High Very High
Togavirus Infection 133 99.40 Very High Very High Very High
Opiate Addiction 1 97.72 Very High Very High Very High
Obesity 11 96.00 Very High Very High Very High
Pancreatic Cancer 53 95.88 Very High Very High Very High
Injury 3 95.88 Very High Very High Very High
Cv Unclassified Under Development 2 94.68 High High
Rheumatoid Arthritis 139 94.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Complete acini expressing E1 could be found from the 17th to the 20th week of gestation onwards.
Gene_expression (expressing) of E1
1) Confidence 0.76 Published 1995 Journal Histochem. Cell Biol. Section Abstract Doc Link 7634150 Disease Relevance 0.34 Pain Relevance 0.09
The levels of E1, E2, P and LH were always within normal values whereas FSH showed lower values than normal and A, DS and PRL noticeably increased in many subjects.
Gene_expression (levels) of E1
2) Confidence 0.26 Published 1981 Journal Drug Alcohol Depend Section Abstract Doc Link 6459917 Disease Relevance 0.20 Pain Relevance 0.45
E1 and PdG are expressed as nanograms and micrograms per mg Cr, respectively.


Gene_expression (expressed) of E1
3) Confidence 0.19 Published 2007 Journal Biopsychosoc Med Section Body Doc Link PMC2253548 Disease Relevance 0 Pain Relevance 0
-dihydro-ASD, testosterone, and negligible amounts of E1, E2, E3, and 16?
Gene_expression (amounts) of E1
4) Confidence 0.14 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257423 Disease Relevance 0.37 Pain Relevance 0.29
-dihydro-ASD, testosterone, and negligible amounts of E1, E2, E3, or 16?
Gene_expression (amounts) of E1
5) Confidence 0.14 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1257423 Disease Relevance 1.62 Pain Relevance 0.81
These changes produced specific amino acid changes in FD08008 (nsP3-M394I, E2-R178H, and 6K-V31I), SD08Pan (nsP1-Q120R, nsP2-G577R, nsP2-N632S, and nsP3- D372N), FD080178 (nsP2-L539S, nsP4-P181S, C-T8A, E2-K252Q, and E1-A306V), and FD080231 (nsP2-L539S, C-T8A, and E2-K252Q) (Table 3).
Gene_expression (produced) of E1 (A306V)
6) Confidence 0.12 Published 2010 Journal Virol J Section Body Doc Link PMC2831882 Disease Relevance 0.20 Pain Relevance 0
The primary physiological estrogens (E1, E2, and E3) are predominantly synthesized in the ovaries, though they can also be synthesized in placenta (especially E3),62 brain,63,64 and fat cells.65 The levels of these hormones are therefore affected by the quantity and state of such non ovarian tissues.
Gene_expression (synthesized) of E1 in fat cells associated with obesity
7) Confidence 0.12 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971739 Disease Relevance 0.35 Pain Relevance 0.09
Results indicated that F5 was able to neutralize all the variant viruses, including v3B2A-9 which is specific for an E1 epitope (Table 5).
Gene_expression (epitope) of E1
8) Confidence 0.08 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2903468 Disease Relevance 0.46 Pain Relevance 0
For the 2003 data and the reduced-form logistic regression model, eigenvectors E1, E7, E12 and E26 account for roughly 40% of the variance in the intercept DFBETA statistic, as do eigenvectors E3, E7, E18, E27 and E29 for the indicator variable DFBETA statistic.
Gene_expression (account) of E1
9) Confidence 0.07 Published 2005 Journal Int J Health Geogr Section Body Doc Link PMC1215506 Disease Relevance 0.06 Pain Relevance 0
In order to examine which lysine linkage utilized by HSP70 binds to p62’s UBA domain, in vitro ubiquitination assay was performed by incubating lysates from HEK cells expressing HSP70 with E1, E2, and E3 in reaction buffer (50 mM Tris-HCl pH 7.5, 2.5 mM MgCl2, 2 mM DTT, 2 mM ATP).
Gene_expression (expressing) of E1
10) Confidence 0.06 Published 2003 Journal Biol Proced Online Section Body Doc Link PMC302190 Disease Relevance 0.09 Pain Relevance 0
In human cells, a single E1 and
Gene_expression (single) of E1
11) Confidence 0.05 Published 2008 Journal PPAR Research Section Body Doc Link PMC2423003 Disease Relevance 0.06 Pain Relevance 0
Moreover, the enzyme aromatase is exclusively found in endometriotic stroma [105] and provides E1, which is further converted to E2 by 17?
Gene_expression (converted) of E1 in stroma associated with endometriosis
12) Confidence 0.05 Published 2007 Journal Semin Immunopathol Section Body Doc Link PMC2668599 Disease Relevance 0.85 Pain Relevance 0.22
E1 estrone, E2 estradiol, P progesterone, PR progesterone receptor, 17?
Gene_expression (estrone) of E1
13) Confidence 0.05 Published 2007 Journal Semin Immunopathol Section Body Doc Link PMC2668599 Disease Relevance 0.85 Pain Relevance 0.18
Moreover, the enzyme aromatase is exclusively found in endometriotic stroma [105] and provides E1, which is further converted to E2 by 17?
Gene_expression (provides) of E1 in stroma associated with endometriosis
14) Confidence 0.05 Published 2007 Journal Semin Immunopathol Section Body Doc Link PMC2668599 Disease Relevance 0.85 Pain Relevance 0.22
For genotype 1a, a significantly higher than expected proportion of unique variations was observed for E1, E2, NS3/4A, NS5A and NS5B.
Gene_expression (/) of E1
15) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815788 Disease Relevance 0.20 Pain Relevance 0
Replication of adenovirus type 5 containing the 0.6 kb midkne promoter (Ad5MK) was assessed by the detection of E1 protein in cancer cell lines.
Gene_expression (detection) of E1 associated with cancer
16) Confidence 0.03 Published 2008 Journal J Exp Clin Cancer Res Section Abstract Doc Link PMC2529268 Disease Relevance 1.14 Pain Relevance 0
In basal layer cells, viral gene expression is largely suppressed, although the limited expression of the early viral genes E1, E2, E5, and especially E6 and E7, results in enhanced proliferation of the infected cells and in their lateral expansion [33].
Gene_expression (expression) of E1 in basal layer
17) Confidence 0.03 Published 2008 Journal Infect Agent Cancer Section Body Doc Link PMC2628336 Disease Relevance 2.39 Pain Relevance 0
Appearance of E1: A226V mutant Chikungunya virus in Coastal Karnataka, India during 2008 outbreak

Chikungunya has resurged in the form of unprecedented explosive epidemic in 2006 after a long gap in India affecting 1.39 million of persons.

Gene_expression (Appearance) of E1 associated with togavirus infection
18) Confidence 0.02 Published 2009 Journal Virol J Section Title Doc Link PMC2774687 Disease Relevance 0.26 Pain Relevance 0

General Comments

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