INT44558

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Context Info
Confidence 0.35
First Reported 1984
Last Reported 2008
Negated 2
Speculated 1
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 3.65
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDXP) plasma membrane (PDXP) cytoplasm (PDXP)
Anatomy Link Frequency
erythrocyte 3
plasma 2
nucleus 1
PDXP (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 76 100.00 Very High Very High Very High
Inflammation 6 94.72 High High
Pain 12 88.88 High High
topical agent 11 5.00 Very Low Very Low Very Low
cryotherapy 9 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 117 100.00 Very High Very High Very High
Carcinoma 27 99.80 Very High Very High Very High
Sickle Cell Anemia 20 99.74 Very High Very High Very High
INFLAMMATION 8 94.72 High High
Aneuploidy 1 91.52 High High
Papillomavirus Infection 58 77.56 Quite High
Cervical Cancer 26 75.68 Quite High
Infection 19 69.92 Quite High
Death 1 68.96 Quite High
Freckles 35 67.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Oral supplementation of five patients with 50 mg pyridoxine twice daily for 2 months resulted in increased plasma and erythrocyte PLP levels and a slight, but not significant, increase in erythrocyte cell number, Hb, concentration, and hematocrit.
Positive_regulation (increased) of PLP in erythrocyte
1) Confidence 0.35 Published 1984 Journal Am. J. Clin. Nutr. Section Abstract Doc Link 6465055 Disease Relevance 0.25 Pain Relevance 0.16
In 16 patients with sickle cell anemia, plasma pyridoxal phosphate (PLP) concentrations were significantly lower than in 16 controls (p less than 0.0001) whereas sickle cell anemia erythrocyte PLP concentrations were significantly elevated (p less than 0.0005), possibly reflecting a greater affinity of PLP to the sickle Hb beta chain compared to the normal beta chain.
Spec (possibly) Positive_regulation (elevated) of PLP in erythrocyte associated with sickle cell anemia
2) Confidence 0.35 Published 1984 Journal Am. J. Clin. Nutr. Section Abstract Doc Link 6465055 Disease Relevance 0.27 Pain Relevance 0.12
Oral supplementation of five patients with 50 mg pyridoxine twice daily for 2 months resulted in increased plasma and erythrocyte PLP levels and a slight, but not significant, increase in erythrocyte cell number, Hb, concentration, and hematocrit.
Neg (not) Positive_regulation (increase) of PLP in erythrocyte
3) Confidence 0.35 Published 1984 Journal Am. J. Clin. Nutr. Section Abstract Doc Link 6465055 Disease Relevance 0.24 Pain Relevance 0.17
Oral supplementation of five patients with 50 mg pyridoxine twice daily for 2 months resulted in increased plasma and erythrocyte PLP levels and a slight, but not significant, increase in erythrocyte cell number, Hb, concentration, and hematocrit.
Neg (not) Positive_regulation (increase) of PLP in plasma
4) Confidence 0.12 Published 1984 Journal Am. J. Clin. Nutr. Section Abstract Doc Link 6465055 Disease Relevance 0.24 Pain Relevance 0.17
Oral supplementation of five patients with 50 mg pyridoxine twice daily for 2 months resulted in increased plasma and erythrocyte PLP levels and a slight, but not significant, increase in erythrocyte cell number, Hb, concentration, and hematocrit.
Positive_regulation (increased) of PLP in plasma
5) Confidence 0.12 Published 1984 Journal Am. J. Clin. Nutr. Section Abstract Doc Link 6465055 Disease Relevance 0.25 Pain Relevance 0.16
Despite the cellular changes induced by topical MMC treatment, the nucleus to cytoplasmic ratio remained constant in nonneoplastic cells, whereas this ratio increased markedly with recurrent CIN (Nadjari et al 1999; McKelvie and Daniell 2001).
Positive_regulation (increased) of CIN in nucleus associated with cancer
6) Confidence 0.10 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2694026 Disease Relevance 1.30 Pain Relevance 0
increase of the four cytokine ratios between CIN III and carcinoma may indicate
Positive_regulation (increase) of CIN III associated with carcinoma and cytokine
7) Confidence 0.03 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2220028 Disease Relevance 1.10 Pain Relevance 0.43

General Comments

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