INT4457

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Context Info
Confidence 0.60
First Reported 1975
Last Reported 2010
Negated 6
Speculated 1
Reported most in Body
Documents 27
Total Number 29
Disease Relevance 14.96
Pain Relevance 7.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Arc) plasma membrane (Arc) cytoskeleton organization (Arc)
cytoplasm (Arc)
Anatomy Link Frequency
ARC 6
neurons 3
dendrites 2
dentate gyrus 2
medial 2
Arc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cocaine 322 99.88 Very High Very High Very High
Central nervous system 38 99.32 Very High Very High Very High
antagonist 125 99.26 Very High Very High Very High
qutenza 8 99.08 Very High Very High Very High
mu opioid receptor 11 98.12 Very High Very High Very High
Neuropeptide 21 97.84 Very High Very High Very High
long-term potentiation 67 97.66 Very High Very High Very High
agonist 63 96.90 Very High Very High Very High
cytokine 1 96.68 Very High Very High Very High
depression 262 94.96 High High
Disease Link Frequency Relevance Heat
Aids-related Complex 505 100.00 Very High Very High Very High
Urological Neuroanatomy 71 100.00 Very High Very High Very High
Apoptosis 13 100.00 Very High Very High Very High
Cognitive Disorder 37 96.52 Very High Very High Very High
Osteogenic Sarcomas 6 96.40 Very High Very High Very High
Depression 284 94.96 High High
Targeted Disruption 99 94.08 High High
Disease 10 93.88 High High
Stress 44 89.20 High High
Diabetes Mellitus 5 86.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In support of this view, it has recently been shown (Ulloor and Datta, 2005) that post-training REM sleep is associated with increased levels of the activity-regulated cytoskeleton-associated protein (Arc), a calcium-dependent immediate early gene (IEG) directly involved in synaptic remodeling (Guzowski et al., 2000; Lyford et al., 1995).
Regulation (regulated) of Arc associated with aids-related complex
1) Confidence 0.60 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0.10 Pain Relevance 0.09
Dysregulation of BDNF synthesis and Arc function, specifically within the dentate gyrus, is linked to behavioral symptoms and cognitive deficits in animal models of depression and Alzheimer's disease.
Regulation (Dysregulation) of Arc in dentate gyrus associated with cognitive disorder, depression, aids-related complex and disease
2) Confidence 0.59 Published 2007 Journal Prog. Brain Res. Section Abstract Doc Link 17765733 Disease Relevance 0.89 Pain Relevance 0.11
The selective 5-HT6 receptor agonist LY-586713, up-regulates (with a bell-shaped dose response) hippocampal BDNF mRNA expression and increases the cortical and hippocampal levels of activity regulated, cytoskeletal-associated protein (Arc).
Regulation (regulated) of cytoskeletal-associated protein associated with aids-related complex and agonist
3) Confidence 0.45 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687932 Disease Relevance 0.36 Pain Relevance 0.72
The selective 5-HT6 receptor agonist LY-586713, up-regulates (with a bell-shaped dose response) hippocampal BDNF mRNA expression and increases the cortical and hippocampal levels of activity regulated, cytoskeletal-associated protein (Arc).
Regulation (regulated) of Arc associated with aids-related complex and agonist
4) Confidence 0.45 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687932 Disease Relevance 0.36 Pain Relevance 0.72
Activity-regulated cytoskeleton-associated protein Arc is targeted to dendrites and coexpressed with mu-opioid receptors in postnatal rat caudate-putamen nucleus.
Regulation (Activity-regulated) of Arc in caudate-putamen associated with aids-related complex and mu opioid receptor
5) Confidence 0.45 Published 2004 Journal J. Neurosci. Res. Section Title Doc Link 15248288 Disease Relevance 0.51 Pain Relevance 0.16
Double-labelling revealed that N/OFQ was present in some neurones located in the ventrolateral part of the Arc producing pro-opiomelanocortin, as shown by the presence of the anorexigenic peptides alpha-melanocyte-stimulating hormone (alpha-MSH) and cocaine- and amphetamine-regulated transcript and, occasionally, in single neurones of the ventrolateral Arc producing orexigenic agouti-related peptide, but not neuropeptide Y.
Regulation (regulated) of Arc in melanocyte associated with aids-related complex, neuropeptide and cocaine
6) Confidence 0.37 Published 2010 Journal J. Neuroendocrinol. Section Abstract Doc Link 20025627 Disease Relevance 0.37 Pain Relevance 0.50
(d) Variation in the threshold hippocampal stimulation during the estrous cycle was observed in the response of MPO and ARC neurons (the stimulation was effective only in proestrus and estrus); but not in that of medial septal neurons.
Regulation (effective) of ARC in medial associated with aids-related complex and urological neuroanatomy
7) Confidence 0.36 Published 1975 Journal Neuroendocrinology Section Abstract Doc Link 1172608 Disease Relevance 0.98 Pain Relevance 0.22
Pre-treatment with the selective 5-HT6 receptor antagonist SB-271046 completely blocks this up-regulation in BDNF and attenuates Arc levels in the respective regions (observed at active dose level of LY-586713).
Regulation (regulation) of Arc associated with aids-related complex and antagonist
8) Confidence 0.33 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687932 Disease Relevance 0.33 Pain Relevance 0.66
In some spiny dendrites, Arc immunoreactivity was more intensely localized in putative spines than in their parental dendrites, whereas, in other spiny dendrites, Arc labeling was restricted in the shafts.
Regulation (immunoreactivity) of Arc in dendrites associated with aids-related complex
9) Confidence 0.27 Published 2004 Journal J. Neurosci. Res. Section Abstract Doc Link 15248288 Disease Relevance 0.65 Pain Relevance 0.20
AIM: The immediate early gene Arc (activity-regulated cytoskeletal-associated protein) mRNA and protein are induced by strong synaptic activation and rapidly transported into dendrites, where they localize at active synaptic sites.
Regulation (regulated) of Arc in dendrites associated with aids-related complex
10) Confidence 0.27 Published 2009 Journal Acta Pharmacol. Sin. Section Abstract Doc Link 19262551 Disease Relevance 0.33 Pain Relevance 0.24
Recent evidence suggests that synaptic consolidation at excitatory medial perforant path-granule cell synapses requires brain-derived neurotrophic factor (BDNF) signaling and induction of the immediate early gene activity-regulated cytoskeleton-associated protein (Arc).
Regulation (regulated) of Arc in medial associated with aids-related complex
11) Confidence 0.26 Published 2007 Journal Prog. Brain Res. Section Abstract Doc Link 17765733 Disease Relevance 0.83 Pain Relevance 0.28
Surprisingly, no significant change in Arc mRNA levels could be observed
Neg (no) Regulation (change) of Arc associated with aids-related complex
12) Confidence 0.25 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0.69 Pain Relevance 0
mRNA levels of Agrp, Pomc and Npy, ARC-expressed genes classically associated with the control of food intake, were not affected by the manipulation of Fto expression.
Neg (not) Regulation (affected) of ARC associated with aids-related complex
13) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808248 Disease Relevance 0.79 Pain Relevance 0
These observations suggest that NO makes a major contribution to the response of the ARC-ME to a stressor such as capsaicin.
Regulation (response) of ARC-ME in ARC associated with qutenza and aids-related complex
14) Confidence 0.19 Published 1999 Journal Neuroreport Section Abstract Doc Link 10363926 Disease Relevance 0.43 Pain Relevance 0.50
associated protein/activity-regulated gene 3.1 (Arc/Arg3.1), and Zif268 (also
Regulation (regulated) of Arc associated with aids-related complex
15) Confidence 0.18 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0.49 Pain Relevance 0.19
We have previously demonstrated the responsiveness of Arc, Fos and Nr4a1 in this animal model [12].
Regulation (responsiveness) of Arc associated with aids-related complex
16) Confidence 0.18 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2837051 Disease Relevance 0.26 Pain Relevance 0.45
In the dentate gyrus of adult rats in vivo, BDNF-LTP induction requires extracellular signal-regulated kinase activation, new gene transcription, and is occluded by prior expression of late LTP [9, 10] BDNF-LTP is associated with rapid upregulation and dendritic transport of mRNA encoded by the immediate early gene, activity-regulated cytoskeleton-associated protein (Arc, aka Arg3.1).
Regulation (regulated) of Arc in dentate gyrus associated with aids-related complex and long-term potentiation
17) Confidence 0.18 Published 2007 Journal Neural Plasticity Section Body Doc Link PMC2248427 Disease Relevance 0.55 Pain Relevance 0.73
The daily rhythm in mu-receptor expression is brought together with the diurnal fluctuation in pro-opiomelanocortin mRNA and the circadian variation in beta-endorphin concentrations in the ARC.
Regulation (concentrations) of ARC in ARC associated with aids-related complex
18) Confidence 0.17 Published 1998 Journal Neuroendocrinology Section Abstract Doc Link 9508039 Disease Relevance 0.29 Pain Relevance 0.30
In conclusion, our data illustrate a novel role for CNS GLP-1 signaling, specifically on ARC neurons, to regulate glucose homeostasis but not food intake.
Neg (not) Regulation (regulate) of ARC in neurons associated with aids-related complex and central nervous system
19) Confidence 0.16 Published 2008 Journal Diabetes Section Body Doc Link PMC2494674 Disease Relevance 0.56 Pain Relevance 0.32
Arc POMC mRNA levels are unchanged compared to controls at 1, 5, 14, or 56 days following imipramine treatment.
Neg (unchanged) Regulation (unchanged) of Arc in Arc associated with aids-related complex
20) Confidence 0.13 Published 1996 Journal J. Neuroendocrinol. Section Abstract Doc Link 8736433 Disease Relevance 0.58 Pain Relevance 0.45

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