INT4458

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Context Info
Confidence 0.49
First Reported 1975
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.19
Pain Relevance 1.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Arc) plasma membrane (Arc) cytoskeleton organization (Arc)
cytoplasm (Arc)
Anatomy Link Frequency
medial 2
neurons 2
MPO 2
Arc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 3 95.48 Very High Very High Very High
Morphine 10 95.08 Very High Very High Very High
Kappa opioid receptor 1 90.28 High High
long-term potentiation 3 89.84 High High
Hippocampus 4 87.28 High High
Dynorphin 1 86.60 High High
Pain 1 85.44 High High
narcan 1 84.80 Quite High
orphanin 2 83.36 Quite High
anesthesia 1 79.24 Quite High
Disease Link Frequency Relevance Heat
Aids-related Complex 20 100.00 Very High Very High Very High
Urological Neuroanatomy 8 99.74 Very High Very High Very High
Depression 3 95.48 Very High Very High Very High
Cognitive Disorder 2 94.60 High High
Stress 1 93.64 High High
Pain 1 85.44 High High
Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Glial fibrillary acidic protein (Gfap) and activity-regulated cytoskeleton-associated protein (Arc) mRNA were upregulated, while growth associated protein (Gap43), clathrin heavy chain (Cltc), alpha-tubulin, Tau, and stathmin were downregulated.
Positive_regulation (upregulated) of Positive_regulation (upregulated) of Arc associated with aids-related complex
1) Confidence 0.49 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 15199374 Disease Relevance 0.10 Pain Relevance 0.39
Recent evidence suggests that synaptic consolidation at excitatory medial perforant path-granule cell synapses requires brain-derived neurotrophic factor (BDNF) signaling and induction of the immediate early gene activity-regulated cytoskeleton-associated protein (Arc).
Positive_regulation (requires) of Positive_regulation (induction) of Arc in medial associated with aids-related complex
2) Confidence 0.48 Published 2007 Journal Prog. Brain Res. Section Abstract Doc Link 17765733 Disease Relevance 0.85 Pain Relevance 0.29
Glial fibrillary acidic protein (Gfap) and activity-regulated cytoskeleton-associated protein (Arc) mRNA were upregulated, while growth associated protein (Gap43), clathrin heavy chain (Cltc), alpha-tubulin, Tau, and stathmin were downregulated.
Positive_regulation (upregulated) of Positive_regulation (upregulated) of activity-regulated cytoskeleton-associated protein associated with aids-related complex
3) Confidence 0.45 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 15199374 Disease Relevance 0.10 Pain Relevance 0.39
Also, the threshold current of MPO stimulation required in increase ARC activity was found to be elevated after ovariectomy and markedly reduced to the levels of the proestrous animal by estrogen treatment.
Positive_regulation (required) of Positive_regulation (increase) of ARC in MPO associated with aids-related complex and urological neuroanatomy
4) Confidence 0.42 Published 1975 Journal Neuroendocrinology Section Abstract Doc Link 1172608 Disease Relevance 0.94 Pain Relevance 0.27
In current clamp, OFQ produced a hyperpolarization of ARC neurons, including those immunopositive for beta-endorphin, tyrosine hydroxylase and gonadotropin-releasing hormone.
Positive_regulation (produced) of Positive_regulation (hyperpolarization) of ARC in neurons associated with aids-related complex
5) Confidence 0.02 Published 1998 Journal Neuroendocrinology Section Abstract Doc Link 9508037 Disease Relevance 0.20 Pain Relevance 0.21

General Comments

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