INT4459

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Context Info
Confidence 0.69
First Reported 1975
Last Reported 2010
Negated 6
Speculated 1
Reported most in Body
Documents 74
Total Number 75
Disease Relevance 33.61
Pain Relevance 28.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Arc) plasma membrane (Arc) cytoskeleton organization (Arc)
cytoplasm (Arc)
Anatomy Link Frequency
ARC 10
dentate gyrus 5
MPO 4
neurons 4
hippocampus 3
Arc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
long-term potentiation 344 100.00 Very High Very High Very High
Central nervous system 78 100.00 Very High Very High Very High
Raphe 27 100.00 Very High Very High Very High
Locus ceruleus 22 100.00 Very High Very High Very High
Nerve growth factor 6 100.00 Very High Very High Very High
electroacupuncture 42 99.98 Very High Very High Very High
qutenza 16 99.98 Very High Very High Very High
opiate 14 99.84 Very High Very High Very High
primary somatosensory cortex 300 99.72 Very High Very High Very High
Dopamine 14 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aids-related Complex 1351 100.00 Very High Very High Very High
Urological Neuroanatomy 117 100.00 Very High Very High Very High
Apoptosis 16 100.00 Very High Very High Very High
Stress 85 99.84 Very High Very High Very High
INFLAMMATION 8 99.44 Very High Very High Very High
Retinal Degeneration 58 98.24 Very High Very High Very High
Body Weight 42 96.04 Very High Very High Very High
Cognitive Disorder 140 95.68 Very High Very High Very High
Depression 210 92.92 High High
Targeted Disruption 87 92.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AIM: The immediate early gene Arc (activity-regulated cytoskeletal-associated protein) mRNA and protein are induced by strong synaptic activation and rapidly transported into dendrites, where they localize at active synaptic sites.
Positive_regulation (induced) of Arc in dendrites associated with aids-related complex
1) Confidence 0.69 Published 2009 Journal Acta Pharmacol. Sin. Section Abstract Doc Link 19262551 Disease Relevance 0.34 Pain Relevance 0.25
RESULTS: Marked increases in Arc protein levels were found in the medial and lateral prefrontal cortex, the sensory cortex, the lateral striatum and the amygdala.
Positive_regulation (increases) of Arc in lateral
2) Confidence 0.69 Published 2009 Journal Acta Pharmacol. Sin. Section Body Doc Link 19262551 Disease Relevance 0 Pain Relevance 0
To the extent that persistent changes in firing rates indicate mnemonic processing (Fuster and Jervey, 1981), and that arc and zif-268 transcriptional upregulation correlates with synaptic remodeling (Guzowski et al., 2000; Jones et al., 2001), our data support the notion that memories produced by novel stimulation during WK are reactivated during SWS and stored during REM sleep, in a two-step consolidation process (Ribeiro and Nicolelis, 2004) otherwise similar to one-step memory reconsolidation (Nader, 2003; Stickgold and Walker, 2005).
Positive_regulation (upregulation) of arc associated with aids-related complex
3) Confidence 0.68 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0.22 Pain Relevance 0.09
As previously noted for WK conditions (Guzowski et al., 2001), the range of arc expression upregulation during REM sleep was twice as large as that of zif-268 (50–60% vs. 20–30%, respectively, Figures 4A and 4B), a difference that fits a direct role of the arc protein on morphological plasticity (Lyford et al., 1995) as well as the indirect, transcriptional role played by the zif-268 protein (Thiel et al., 1994; Wisden et al., 1990).
Positive_regulation (upregulation) of arc associated with aids-related complex
4) Confidence 0.68 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0.34 Pain Relevance 0.19
The same research group, using the two-way active-avoidance learning paradigm, showed that the increase in pontine-wave density during post-training REM sleep is positively correlated with the increased levels of phosphorylated cAMP response element-binding protein (CREB), brain-derived nerve growth factor (BDNF), and Arc protein in the dorsal hippocampus (Ulloor and Datta, 2005).
Positive_regulation (increased) of Arc protein in hippocampus associated with nerve growth factor, aids-related complex and hippocampus
5) Confidence 0.68 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0.24 Pain Relevance 0.10
Glial fibrillary acidic protein (Gfap) and activity-regulated cytoskeleton-associated protein (Arc) mRNA were upregulated, while growth associated protein (Gap43), clathrin heavy chain (Cltc), alpha-tubulin, Tau, and stathmin were downregulated.
Positive_regulation (upregulated) of Arc associated with aids-related complex
6) Confidence 0.67 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 15199374 Disease Relevance 0.10 Pain Relevance 0.39
Interestingly, the CeA showed an opposite pattern of responding, and the intercalated cell masses (ITC), a possible inhibitory interface between the BLA and CeA, showed a persistent activation of c-fos and arc mRNA.
Positive_regulation (activation) of arc associated with aids-related complex
7) Confidence 0.67 Published 2008 Journal Neuroscience Section Abstract Doc Link 18501523 Disease Relevance 0.49 Pain Relevance 0.92
Arc mRNA is strongly induced and transported to dendritic processes following high-frequency stimulation (HFS) that induces LTP in the rat dentate gyrus in vivo.
Positive_regulation (induced) of Arc mRNA in dentate gyrus associated with aids-related complex and long-term potentiation
8) Confidence 0.66 Published 2007 Journal Prog. Brain Res. Section Abstract Doc Link 17765733 Disease Relevance 0.83 Pain Relevance 0.28
Recent evidence suggests that synaptic consolidation at excitatory medial perforant path-granule cell synapses requires brain-derived neurotrophic factor (BDNF) signaling and induction of the immediate early gene activity-regulated cytoskeleton-associated protein (Arc).
Positive_regulation (induction) of Arc in medial associated with aids-related complex
9) Confidence 0.66 Published 2007 Journal Prog. Brain Res. Section Abstract Doc Link 17765733 Disease Relevance 0.84 Pain Relevance 0.29
induced in the dorsal blade. (3) The levels of Arc, ?
Positive_regulation (induced) of Arc in dorsal associated with aids-related complex
10) Confidence 0.64 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0.82 Pain Relevance 0
shown histochemically by the upregulation of Arc, Zif268, and to a lesser
Positive_regulation (upregulation) of Arc associated with aids-related complex
11) Confidence 0.64 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0.83 Pain Relevance 0
Also, the threshold current of MPO stimulation required in increase ARC activity was found to be elevated after ovariectomy and markedly reduced to the levels of the proestrous animal by estrogen treatment.
Positive_regulation (increase) of ARC in MPO associated with aids-related complex and urological neuroanatomy
12) Confidence 0.63 Published 1975 Journal Neuroendocrinology Section Abstract Doc Link 1172608 Disease Relevance 0.94 Pain Relevance 0.27
In addition, Arc was also induced regionally in the striatum.
Positive_regulation (induced) of Arc in striatum associated with aids-related complex
13) Confidence 0.62 Published 2007 Journal BMC Biol Section Body Doc Link PMC1868707 Disease Relevance 0.52 Pain Relevance 0.33
Glial fibrillary acidic protein (Gfap) and activity-regulated cytoskeleton-associated protein (Arc) mRNA were upregulated, while growth associated protein (Gap43), clathrin heavy chain (Cltc), alpha-tubulin, Tau, and stathmin were downregulated.
Positive_regulation (upregulated) of activity-regulated cytoskeleton-associated protein associated with aids-related complex
14) Confidence 0.62 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 15199374 Disease Relevance 0.10 Pain Relevance 0.39
There were significant increases in arc in all of the cortical regions analyzed.
Positive_regulation (increases) of arc associated with aids-related complex
15) Confidence 0.54 Published 2007 Journal BMC Biol Section Body Doc Link PMC1868707 Disease Relevance 0.54 Pain Relevance 0.29
BV acupoint stimulation significantly increased Fos-TH double-labeled neurons in the Arc, LC and DR.
Positive_regulation (increased) of Arc in Arc associated with aids-related complex, locus ceruleus and raphe
16) Confidence 0.49 Published 2004 Journal Mol. Cells Section Abstract Doc Link 15179050 Disease Relevance 0.28 Pain Relevance 0.53
IEG upregulation after a few (Ribeiro et al., 1999, 2002) or many (Figure 4) sleep cycles is a plausible explanation for late waves of arc and zif-268 gene expression upregulation many hours after memory acquisition (Bekinschtein et al., 2007; Grimm and Tischmeyer, 1997).
Positive_regulation (upregulation) of arc associated with aids-related complex
17) Confidence 0.49 Published 2007 Journal Frontiers in Neuroscience Section Body Doc Link PMC2577304 Disease Relevance 0.10 Pain Relevance 0.03
Glial fibrillary acidic protein (Gfap) and activity-regulated cytoskeleton-associated protein (Arc) mRNA were upregulated, while growth associated protein (Gap43), clathrin heavy chain (Cltc), alpha-tubulin, Tau, and stathmin were downregulated.
Positive_regulation (upregulated) of Arc associated with aids-related complex
18) Confidence 0.49 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 15199374 Disease Relevance 0.10 Pain Relevance 0.39
stringent requirement for Arc
Positive_regulation (requirement) of Arc associated with aids-related complex
19) Confidence 0.46 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0.49 Pain Relevance 0.20
However, as also observed for Arc, the density of
Positive_regulation (observed) of Arc associated with aids-related complex
20) Confidence 0.46 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0.37 Pain Relevance 0

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