INT4460

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Context Info
Confidence 0.62
First Reported 1975
Last Reported 2010
Negated 14
Speculated 2
Reported most in Abstract
Documents 44
Total Number 46
Disease Relevance 31.16
Pain Relevance 12.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mpo) extracellular space (Mpo) aging (Mpo)
Anatomy Link Frequency
plasma 4
granulocytes 3
PGE2 2
leukocytes 2
visceral 1
Mpo (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 70 100.00 Very High Very High Very High
ischemia 36 100.00 Very High Very High Very High
withdrawal 6 99.68 Very High Very High Very High
Rostral ventromedial medulla 8 99.64 Very High Very High Very High
Inflammation 152 99.50 Very High Very High Very High
qutenza 18 99.44 Very High Very High Very High
anesthesia 15 99.26 Very High Very High Very High
ketamine 6 99.04 Very High Very High Very High
Morphine 20 98.84 Very High Very High Very High
Thermal hyperalgesia 2 98.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 257 100.00 Very High Very High Very High
INFLAMMATION 186 100.00 Very High Very High Very High
Diabetes Mellitus 75 100.00 Very High Very High Very High
Cv Unclassified Under Development 31 100.00 Very High Very High Very High
Myocardial Infarction 15 100.00 Very High Very High Very High
Aids-related Complex 10 100.00 Very High Very High Very High
Reperfusion Injury 10 100.00 Very High Very High Very High
Injury 202 99.90 Very High Very High Very High
Poisoning 66 99.84 Very High Very High Very High
Coronary Artery Disease 6 99.82 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect on myeloperoxidase activity was seen during the period 21-24 hours after trinitrobenzene sulfonic acid ethanol administration, but not during the period 45-48 hours after induction of colitis.
Regulation (effect) of myeloperoxidase associated with colitis
1) Confidence 0.62 Published 1992 Journal Gastroenterology Section Abstract Doc Link 1309357 Disease Relevance 0.58 Pain Relevance 0.07
Capsaicin treatment did not have any effect on MPO activity in indomethacin-treated rats or in rats submitted to surgery for duodeno-gastric reflux.
Regulation (effect) of MPO associated with qutenza, urological neuroanatomy and nud
2) Confidence 0.62 Published 2004 Journal Auton Neurosci Section Abstract Doc Link 15046732 Disease Relevance 1.59 Pain Relevance 0.87
RESULTS: Morphine (37, 75, and 150 nmol) inhibited inflammatory edema, but had no effect on MPO activity.
Neg (no) Regulation (effect) of MPO
3) Confidence 0.62 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18292447 Disease Relevance 0.09 Pain Relevance 0
The effects of these extracts on myeloperoxidase (MPO), an enzyme liberated by activated granulocytes and known to produce the destructive agent hypochloric acid, were investigated.
Spec (investigated) Regulation (effects) of MPO in granulocytes associated with urological neuroanatomy
4) Confidence 0.62 Published 1996 Journal Arzneimittelforschung Section Abstract Doc Link 9125284 Disease Relevance 0.51 Pain Relevance 0.10
In this study we tested the hypothesis that levels of MPO in plasma after a myocardial infarction are affected by its ability to bind to the endothelium and there is local release of the enzyme at the culprit lesion.
Regulation (affected) of MPO in plasma associated with urological neuroanatomy and myocardial infarction
5) Confidence 0.62 Published 2010 Journal Am. J. Cardiol. Section Abstract Doc Link 20643239 Disease Relevance 0.84 Pain Relevance 0.06
The influence of oxygen free radical scavengers and anti-inflammatory drugs on postischemic lipid peroxidation and myeloperoxidase activity was shown.
Regulation (influence) of myeloperoxidase associated with inflammation and cinod
6) Confidence 0.60 Published 1992 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 1337651 Disease Relevance 0.41 Pain Relevance 0.25
Treatment of the animals with metamizol neither modified the MPO activity nor TNF-alpha levels.
Neg (neither) Regulation (modified) of MPO
7) Confidence 0.60 Published 2002 Journal Inflamm. Res. Section Body Doc Link 12234055 Disease Relevance 0 Pain Relevance 0
The effects of Rofecoxib on histological damage, intestinal myeloperoxidase (MPO) activity, and malondialdehyde (MDA) levels were also measured.
Regulation (effects) of MPO
8) Confidence 0.60 Published 2006 Journal J. Surg. Res. Section Body Doc Link 16780881 Disease Relevance 0.08 Pain Relevance 0
The effects of Rofecoxib on histological damage, intestinal myeloperoxidase (MPO) activity, and malondialdehyde (MDA) levels were also measured.
Regulation (effects) of intestinal myeloperoxidase
9) Confidence 0.60 Published 2006 Journal J. Surg. Res. Section Body Doc Link 16780881 Disease Relevance 0.08 Pain Relevance 0
Most NSAIDs which affected both MPO and NaOCl-CL appeared to share similar mechanisms, suggesting that MPO oxidant intermediates and HOCl are susceptible to NSAID effects.
Regulation (affected) of MPO associated with cinod and urological neuroanatomy
10) Confidence 0.59 Published 1982 Journal Agents Actions Section Abstract Doc Link 6282074 Disease Relevance 1.38 Pain Relevance 1.00
Myeloperoxidase (MPO), a marker enzyme of leukocytes, was unaffected by indomethacin administration.
Neg (unaffected) Regulation (unaffected) of MPO in leukocytes associated with urological neuroanatomy
11) Confidence 0.59 Published 1996 Journal Biol. Pharm. Bull. Section Abstract Doc Link 8741581 Disease Relevance 0.44 Pain Relevance 0.08
Myeloperoxidase (MPO), a marker enzyme of leukocytes, was unaffected by indomethacin administration.
Neg (unaffected) Regulation (unaffected) of Myeloperoxidase in leukocytes associated with urological neuroanatomy
12) Confidence 0.59 Published 1996 Journal Biol. Pharm. Bull. Section Abstract Doc Link 8741581 Disease Relevance 0.44 Pain Relevance 0.08
However, the same doses of octacosanol given to rats without CCl4 intoxication had no effect on the hepatic MPO activity.
Neg (no) Regulation (effect) of MPO associated with urological neuroanatomy and poisoning
13) Confidence 0.56 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266062 Disease Relevance 1.32 Pain Relevance 0.09
In contrast, treatment with iCORM-2 did not affect tissue MPO activity.
Neg (not) Regulation (affect) of MPO associated with urological neuroanatomy
14) Confidence 0.49 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2873601 Disease Relevance 0.97 Pain Relevance 0.16
However, lidocaine administration in capsaicin-treated rats attenuated the macroscopic damage but did not improve MPO activity or histology.
Neg (not) Regulation (improve) of MPO associated with qutenza, urological neuroanatomy and lidocaine
15) Confidence 0.45 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9124351 Disease Relevance 0.72 Pain Relevance 0.96
To assess their impact on MPO measurements, celecoxib and morphine, two drugs of already demonstrated efficacy on cell migration were investigated in the periodontal disease model.
Regulation (impact) of MPO associated with periodontal disease, urological neuroanatomy and morphine
16) Confidence 0.45 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2804053 Disease Relevance 0.26 Pain Relevance 0.27
The effects of these extracts on myeloperoxidase (MPO), an enzyme liberated by activated granulocytes and known to produce the destructive agent hypochloric acid, were investigated.
Spec (investigated) Regulation (effects) of myeloperoxidase in granulocytes associated with urological neuroanatomy
17) Confidence 0.45 Published 1996 Journal Arzneimittelforschung Section Abstract Doc Link 9125284 Disease Relevance 0.50 Pain Relevance 0.10
(d) Variation in the threshold hippocampal stimulation during the estrous cycle was observed in the response of MPO and ARC neurons (the stimulation was effective only in proestrus and estrus); but not in that of medial septal neurons.
Regulation (effective) of MPO in medial associated with aids-related complex and urological neuroanatomy
18) Confidence 0.45 Published 1975 Journal Neuroendocrinology Section Abstract Doc Link 1172608 Disease Relevance 0.99 Pain Relevance 0.22
Lansoprazole at 90 micromol/kg reversed also the effects of NSAIDs on MPO, MDA and GSH mucosal contents, without interfering with the decrease in PGE2 levels or indomethacin-induced cyclooxygenase-2 expression.
Regulation (effects) of MPO
19) Confidence 0.45 Published 2005 Journal World J. Gastroenterol. Section Body Doc Link 15996031 Disease Relevance 0 Pain Relevance 0
Pantoprazole 60 micromol/kg also reversed the effects of NSAIDs on MPO, MDA, and GSH mucosal contents, without interfering with the decrease in PGE2 levels or indomethacin-induced COX-2 expression.
Regulation (effects) of MPO in PGE2 associated with cinod and urological neuroanatomy
20) Confidence 0.45 Published 2005 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 16080005 Disease Relevance 0.40 Pain Relevance 0.54

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