INT44600

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Context Info
Confidence 0.75
First Reported 1984
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 6.14
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MALT1) peptidase activity (MALT1) nucleolus (MALT1)
nucleus (MALT1) protein complex (MALT1) cytoplasm (MALT1)
Anatomy Link Frequency
MALT 4
MOLT-4 1
MALT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 5 98.64 Very High Very High Very High
abdominal pain 3 68.72 Quite High
cytokine 13 48.24 Quite Low
chemokine 5 43.96 Quite Low
lidocaine 1 41.12 Quite Low
imagery 6 25.88 Quite Low
Inflammation 14 24.24 Low Low
headache 6 23.12 Low Low
rheumatoid arthritis 1 18.72 Low Low
Central nervous system 40 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 273 99.78 Very High Very High Very High
Malignant Neoplastic Disease 12 99.44 Very High Very High Very High
Diffuse Large B-cell Lymphoma 56 98.16 Very High Very High Very High
INFLAMMATION 16 96.08 Very High Very High Very High
Cancer 85 91.72 High High
Frailty 19 91.20 High High
Appetite Loss 5 85.80 High High
Stress 8 83.40 Quite High
Pressure And Volume Under Development 3 81.96 Quite High
Ascariasis 2 79.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intestinal MALT lymphomas with API2-MALT1 expression have distinctive forms of infiltration compared with those without translocation.
Gene_expression (expression) of MALT1 in MALT associated with lymphatic system cancer
1) Confidence 0.75 Published 2004 Journal Pathol. Int. Section Abstract Doc Link 15363040 Disease Relevance 0.98 Pain Relevance 0.06
Expression of API2-MALT1 fusion transcripts was detected by reverse transcription-polymerase chain reaction analysis using formalin-fixed, paraffin-embedded tissue.
Gene_expression (Expression) of MALT1
2) Confidence 0.75 Published 2004 Journal Pathol. Int. Section Abstract Doc Link 15363040 Disease Relevance 1.05 Pain Relevance 0.07
3) but remained unknown in the remaining 18 cases. t(14;18)/IGH-BCL2, t(14;18)/IGH-MALT1, and t(1;14)/BCL10-IGH were not detected in any case. t(11;18)/API2-MALT1 was detected in none of the cases, except for one case of DLBCL with MALT lymphoma, which showed positive signals only in MALT lymphoma cells.
Neg (except) Gene_expression (detected) of MALT1 in MALT associated with lymphatic system cancer and diffuse large b-cell lymphoma
3) Confidence 0.65 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.36 Pain Relevance 0
In ten human malignant T-cell lines (HPB-ALL, HPB-MLT, CCRF-CEM, RPMI-8402, MOLT-4, JM, P12/Ichikawa, TALL-1, SKW-3, HUT-102), the expression of the antigen defined by OKT-4 or Leu-3A monoclonal antibody was remarkably decreased after a short incubation (1 hr) with 12-0-tetradecanoylphorbol-13-acetate (TPA) (1.6 nM).
Gene_expression (expression) of MLT in MOLT-4 associated with malignant neoplastic disease
4) Confidence 0.58 Published 1984 Journal Am. J. Hematol. Section Abstract Doc Link 6475939 Disease Relevance 0.22 Pain Relevance 0
In conclusion, we report a rare case of primary dural MALT lymphoma with prominent plasmacytic differentiation and the diagnosis was confirmed by a monoclonal IgH gene rearrangement and a positive MALT1 rearrangement involving IgH and MALT1 on chromosome 14 and 18, respectively.



Gene_expression (rearrangement) of MALT1 in MALT associated with lymphatic system cancer
5) Confidence 0.50 Published 2008 Journal J Hematop Section Body Doc Link PMC2713483 Disease Relevance 0.61 Pain Relevance 0
In conclusion, we report a rare case of primary dural MALT lymphoma with prominent plasmacytic differentiation and the diagnosis was confirmed by a monoclonal IgH gene rearrangement and a positive MALT1 rearrangement involving IgH and MALT1 on chromosome 14 and 18, respectively.



Gene_expression (rearrangement) of MALT1 in MALT associated with lymphatic system cancer
6) Confidence 0.50 Published 2008 Journal J Hematop Section Body Doc Link PMC2713483 Disease Relevance 0.61 Pain Relevance 0
The normal IgH and MALT1 loci are represented by the single red and single green signals respectively (×100)
Gene_expression (loci) of MALT1
7) Confidence 0.50 Published 2008 Journal J Hematop Section Body Doc Link PMC2713483 Disease Relevance 0.81 Pain Relevance 0
Glutamine, the major source of the small intestinal mucosa, may be partially normalize this NSAID-induced permeability [37,45].


Gene_expression (source) of mucosa associated with cinod
8) Confidence 0.01 Published 2005 Journal BMC Nurs Section Body Doc Link PMC549542 Disease Relevance 0.49 Pain Relevance 0.29

General Comments

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