INT44602

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Context Info
Confidence 0.75
First Reported 1984
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 37
Total Number 40
Disease Relevance 30.98
Pain Relevance 9.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (TNFSF13B) signal transduction (TNFSF13B) extracellular space (TNFSF13B)
extracellular region (TNFSF13B) plasma membrane (TNFSF13B)
Anatomy Link Frequency
B-cell 11
macrophages 3
dendritic cells 3
monocytes 3
mature B-cells 2
TNFSF13B (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 180 100.00 Very High Very High Very High
antagonist 60 100.00 Very High Very High Very High
rheumatoid arthritis 141 99.92 Very High Very High Very High
dexamethasone 56 99.80 Very High Very High Very High
Multiple sclerosis 24 99.08 Very High Very High Very High
Inflammation 106 98.80 Very High Very High Very High
cINOD 17 93.96 High High
abatacept 6 91.12 High High
headache 26 77.72 Quite High
chemokine 120 70.00 Quite High
Disease Link Frequency Relevance Heat
Necrosis 44 100.00 Very High Very High Very High
Cancer 40 100.00 Very High Very High Very High
Systemic Lupus Erythematosus 628 99.92 Very High Very High Very High
Rheumatoid Arthritis 141 99.92 Very High Very High Very High
Autoimmune Disease 83 99.92 Very High Very High Very High
Targeted Disruption 13 99.84 Very High Very High Very High
Disease Progression 10 99.28 Very High Very High Very High
Demyelinating Disease 24 99.08 Very High Very High Very High
INFLAMMATION 118 98.80 Very High Very High Very High
Malignant Neoplastic Disease 15 98.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of B-cell-activating factor of the TNF family (BAFF) and its receptors in multiple sclerosis.
Gene_expression (Expression) of BAFF in B-cell associated with multiple sclerosis
1) Confidence 0.75 Published 2004 Journal J. Neuroimmunol. Section Title Doc Link 15223251 Disease Relevance 0.64 Pain Relevance 0.30
We investigated the expression of B-cell-activating factor of the tumor necrosis factor family (BAFF), a protein indispensable for B-cell survival, and of its three receptors in MS patients and controls.
Spec (investigated) Gene_expression (expression) of BAFF in B-cell associated with necrosis, multiple sclerosis and cancer
2) Confidence 0.75 Published 2004 Journal J. Neuroimmunol. Section Abstract Doc Link 15223251 Disease Relevance 0.64 Pain Relevance 0.30
In contrast, BLyS receptors are not expressed on bone marrow B-cell precursors but are expressed on immature and mature B-cells, memory cells, and plasma cells.
Gene_expression (expressed) of BLyS in mature B-cells
3) Confidence 0.56 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592791 Disease Relevance 0.58 Pain Relevance 0.14
In contrast, BLyS receptors are not expressed on bone marrow B-cell precursors but are expressed on immature and mature B-cells, memory cells, and plasma cells.
Neg (not) Gene_expression (expressed) of BLyS in mature B-cells
4) Confidence 0.56 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592791 Disease Relevance 0.57 Pain Relevance 0.13
Constitutive over-expression of BLyS in transgenic mice results in the development of an autoimmune-like disease that is characterized by hypergammaglobulinemia, autoantibody production, and glomerulonephritis [8,12,13].
Gene_expression (over) of BLyS associated with targeted disruption, hypergammaglobulinemia, renal disease and disease
5) Confidence 0.48 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592791 Disease Relevance 1.16 Pain Relevance 0.08
BLyS levels could not be measured because the presence of belimumab in the blood interfered with the detection of BLyS.


Gene_expression (detection) of BLyS in blood
6) Confidence 0.48 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592791 Disease Relevance 0 Pain Relevance 0
B-lymphocyte stimulator (BLyS) is a member of the tumor necrosis factor (TNF) ligand superfamily of cytokines that is expressed and secreted by monocytes, macrophages, dendritic cells, and granulocyte colony-stimulating factor activated neutrophils [5,6].
Gene_expression (expressed) of BLyS in dendritic cells associated with necrosis, cancer and cytokine
7) Confidence 0.48 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592791 Disease Relevance 1.00 Pain Relevance 0.05
Overproduction of BAFF in transgenic mice has been shown to result in B cell proliferation and antibody production resulting in inflammation and destruction of the salivary glands, as well as kidney failure similar to observations seen in SLE [10].
Gene_expression (Overproduction) of BAFF in B cell associated with targeted disruption, inflammation, renal failure, salivary gland disease and systemic lupus erythematosus
8) Confidence 0.46 Published 2007 Journal Clin Rev Allergy Immunol Section Body Doc Link PMC2071970 Disease Relevance 1.76 Pain Relevance 0.11
However, circulating levels of BAFF in pSS patients were shown to be a marker for disease activity [11].
Gene_expression (levels) of BAFF associated with disease
9) Confidence 0.46 Published 2007 Journal Clin Rev Allergy Immunol Section Body Doc Link PMC2071970 Disease Relevance 0.83 Pain Relevance 0.04
Dysregulated BAFF expression is implicated in disease progression and perpetuation of humoral autoimmunity.
Gene_expression (expression) of BAFF associated with autoimmune disease and disease progression
10) Confidence 0.46 Published 2007 Journal Clin Rev Allergy Immunol Section Body Doc Link PMC2071970 Disease Relevance 1.67 Pain Relevance 0.11
In ten human malignant T-cell lines (HPB-ALL, HPB-MLT, CCRF-CEM, RPMI-8402, MOLT-4, JM, P12/Ichikawa, TALL-1, SKW-3, HUT-102), the expression of the antigen defined by OKT-4 or Leu-3A monoclonal antibody was remarkably decreased after a short incubation (1 hr) with 12-0-tetradecanoylphorbol-13-acetate (TPA) (1.6 nM).
Gene_expression (expression) of TALL-1 in MOLT-4 associated with malignant neoplastic disease
11) Confidence 0.41 Published 1984 Journal Am. J. Hematol. Section Abstract Doc Link 6475939 Disease Relevance 0.22 Pain Relevance 0
Constitutive over-expression of BLyS in transgenic mice results in the development of an autoimmune-like disease that is characterized by hypergammaglobulinemia, autoantibody production, and glomerulonephritis [8,12,13].
Gene_expression (expression) of BLyS associated with targeted disruption, hypergammaglobulinemia, renal disease and disease
12) Confidence 0.38 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592791 Disease Relevance 1.16 Pain Relevance 0.08
Constitutive over-expression of BLyS in transgenic mice results in the development of an autoimmune-like disease that is characterized by hypergammaglobulinemia, autoantibody production, and glomerulonephritis [8,12,13].
Gene_expression (-) of BLyS associated with targeted disruption, hypergammaglobulinemia, renal disease and disease
13) Confidence 0.38 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592791 Disease Relevance 1.16 Pain Relevance 0.08
B-lymphocyte stimulator (BLyS) is a member of the tumor necrosis factor (TNF) ligand superfamily of cytokines that is expressed and secreted by monocytes, macrophages, dendritic cells, and granulocyte colony-stimulating factor activated neutrophils [5,6].
Gene_expression (expressed) of BLyS in monocytes associated with necrosis, cancer and cytokine
14) Confidence 0.16 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592791 Disease Relevance 1.00 Pain Relevance 0.05
B-lymphocyte stimulator (BLyS) is a member of the tumor necrosis factor (TNF) ligand superfamily of cytokines that is expressed and secreted by monocytes, macrophages, dendritic cells, and granulocyte colony-stimulating factor activated neutrophils [5,6].
Gene_expression (expressed) of BLyS in macrophages associated with necrosis, cancer and cytokine
15) Confidence 0.16 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592791 Disease Relevance 1.00 Pain Relevance 0.05
B-lymphocyte stimulator (BLyS) is a member of the tumor necrosis factor (TNF) ligand superfamily of cytokines that is expressed and secreted by monocytes, macrophages, dendritic cells, and granulocyte colony-stimulating factor activated neutrophils [5,6].
Gene_expression (expressed) of BLyS in granulocyte associated with necrosis, cancer and cytokine
16) Confidence 0.16 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592791 Disease Relevance 1.00 Pain Relevance 0.05
Inflammatory cytokines and CD40 ligand are well-established inducers of BAFF production by monocytes, macrophages and dendritic cells [48] and, moreover, He et al have recently shown that gp120-induced production of BAFF by monocytes enhances the polyclonal IgG and IgA production by a subset of gp120-activated MGZ-like B-cells [19].
Gene_expression (production) of BAFF in dendritic cells associated with inflammation and cytokine
17) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695011 Disease Relevance 0.52 Pain Relevance 0.14
Inflammatory cytokines and CD40 ligand are well-established inducers of BAFF production by monocytes, macrophages and dendritic cells [48] and, moreover, He et al have recently shown that gp120-induced production of BAFF by monocytes enhances the polyclonal IgG and IgA production by a subset of gp120-activated MGZ-like B-cells [19].
Gene_expression (production) of BAFF in dendritic cells associated with inflammation and cytokine
18) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695011 Disease Relevance 0.45 Pain Relevance 0.13
BAFF production may therefore be triggered during acute SIV-infection and contributes to the early, potentially T-independent increase in plasma IgG/M.
Gene_expression (production) of BAFF in plasma associated with infection
19) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695011 Disease Relevance 0.49 Pain Relevance 0.12
Expression of B-cell-activating factor of the TNF family (BAFF) and its receptors in multiple sclerosis.
Gene_expression (Expression) of B-cell-activating factor in B-cell associated with multiple sclerosis
20) Confidence 0.12 Published 2004 Journal J. Neuroimmunol. Section Title Doc Link 15223251 Disease Relevance 0.63 Pain Relevance 0.30

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