INT44608

Context Info Confidence 0.75 First Reported 1984 Last Reported 2010 Negated 4 Speculated 0 Reported most in Body Documents 45 Total Number 46 Disease Relevance 15.84 Pain Relevance 5.05

peptidase activity (C2) extracellular space (C2) extracellular region (C2)

Anatomy Link Frequency gut 2 blood 2 SH-SY5Y 1 vertebral artery 1 muscle 1 C2 (Homo sapiens)

Pain Link Frequency Relevance Heat Spinal cord 20 100.00 Neuropeptide 20 99.98 narcan 9 99.80 Migraine 6 99.80 neuralgia 5 99.20 abdominal pain 1 99.16 Pain 140 98.96 Immobilon 6 98.92 Thoracotomy 12 98.84 agonist 11 98.72

Disease Link Frequency Relevance Heat Cough 546 100.00 Disorder Of Lipid Metabolism 8 100.00 Lactic Acidosis 6 99.90 Aspiration Pneumonia 94 99.82 Headache 8 99.80 Disease 185 99.54 Pressure Volume 2 Under Development 117 99.52 Abdominal Pain 1 99.16 Pain 135 98.96 Kyphosis 16 98.18

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Furthermore, the Golgi-disturbing agents brefeldin A and monensin completely blocked naloxone-enhanced expression of i3-1 and C-2 mutants.

Gene_expression (expression) of C-2 associated with narcan

1) Confidence 0.75 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 12815158 Disease Relevance 0 Pain Relevance 0.43

The cell surface-expressed mutant C-2, but not i3-1, fully retained ability to mediate inhibition of adenylyl cyclase activity.

Neg (not) Gene_expression (expressed) of C-2

2) Confidence 0.75 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 12815158 Disease Relevance 0 Pain Relevance 0.44

2. the VMR phase, in which there is a strong increase of the O2Hb (and, hence, of the total hemoglobin, that roughly corresponds to the regional cerebral blood volume) while the CO2Hb is kept at a baseline level;

Gene_expression (kept) of CO2Hb in blood

3) Confidence 0.67 Published 2006 Journal J Neuroengineering Rehabil Section Body Doc Link PMC1544341 Disease Relevance 0.17 Pain Relevance 0.03

When the vasodilation has reached its maximum, there's a plateau region in which the O2Hb concentration remains almost constant, while the CO2Hb concentration starts increasing; afterwards, BH ends.

Gene_expression (concentration) of CO2Hb associated with increased venous pressure under development

4) Confidence 0.67 Published 2006 Journal J Neuroengineering Rehabil Section Body Doc Link PMC1544341 Disease Relevance 0.10 Pain Relevance 0

[Surgical decompression for the C-1 and C-2 sensory roots and upper cervical cord in a case with cervical myelopathy and occipital neuralgia due to bilateral fenestration of vertebral artery: a case report].

Gene_expression (roots) of C-2 in vertebral artery associated with spinal cord diseases, neuralgia and occipital neuralgia

5) Confidence 0.65 Published 1993 Journal No Shinkei Geka Section Title Doc Link 8255379 Disease Relevance 0.44 Pain Relevance 0.51

As shown in Figure 1A, the cough reflex threshold to citric acid, as expressed by log C2, in patients with aspiration pneumonia (1.5 ± 0.6 g/l) was significantly higher than those of control (0.6 ± 0.4 g/l, p < 0.05).

Gene_expression (expressed) of C2 associated with cough and aspiration pneumonia

6) Confidence 0.65 Published 2008 Journal Cough Section Body Doc Link PMC2600632 Disease Relevance 1.53 Pain Relevance 0

There was a significantly higher peak pain rating after D2 compared to C2 during MVBF or MVJO (P<0.022), whereas no significant difference in peak pain ratings was found between A2 and B2 (P>0.084).

Neg (no) Gene_expression (was) of C2

7) Confidence 0.64 Published 2010 Journal Clin Neurophysiol Section Body Doc Link 20153690 Disease Relevance 0 Pain Relevance 0

Traditionally, in response to a CO2 test, VMR is quantified by relating baseline values (these values can be the mean CBFV as well as the concentrations of O2Hb and CO2Hb) to post – stimulus values [9]; while the stimulus phase is not taken into consideration.

Gene_expression (concentrations) of CO2Hb

8) Confidence 0.60 Published 2006 Journal J Neuroengineering Rehabil Section Body Doc Link PMC1544341 Disease Relevance 0.32 Pain Relevance 0.13

How then does one type of inhalation challenge cause a larger reduction in subsequent C2 and the other not?

Gene_expression (reduction) of C2 associated with cough

9) Confidence 0.58 Published 2010 Journal Cough Section Body Doc Link PMC2925329 Disease Relevance 0.96 Pain Relevance 0.13

How then does one type of inhalation challenge cause a larger reduction in subsequent C2 and the other not?

Gene_expression (subsequent) of C2 associated with cough

10) Confidence 0.58 Published 2010 Journal Cough Section Body Doc Link PMC2925329 Disease Relevance 0.96 Pain Relevance 0.13

= 0.05) and 0.603 (BHIV vs slope of the CO2Hb signal; P < 4·10-3, ?

Gene_expression (signal) of CO2Hb

11) Confidence 0.58 Published 2006 Journal J Neuroengineering Rehabil Section Body Doc Link PMC1544341 Disease Relevance 0.06 Pain Relevance 0.04

We applied TCD and NIRS during baseline conditions and during CO2 reactivity.

Gene_expression (applied) of CO2

12) Confidence 0.58 Published 2006 Journal J Neuroengineering Rehabil Section Body Doc Link PMC1544341 Disease Relevance 0.58 Pain Relevance 0

Treatment with the opioid antagonist naloxone, the agonist etorphine, and other hydrophobic ligands enhanced cell surface expression of i3-1 and C-2 mutants.

Gene_expression (expression) of C-2 associated with antagonist, agonist, narcan, opioid and immobilon

13) Confidence 0.58 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 12815158 Disease Relevance 0 Pain Relevance 0.41

In the study, all patients with aspiration pneumonia did not cough at C2/2, and 6 of 8 did not at C5/2.

Neg (not) Gene_expression (cough) of C2 associated with cough and aspiration pneumonia

14) Confidence 0.56 Published 2008 Journal Cough Section Body Doc Link PMC2600632 Disease Relevance 3.08 Pain Relevance 0.03

MHC complement gene haplotypes or complotypes are designated by their BF, C2, C4A, and C4B alleles, in that arbitrary order [7].

Gene_expression (alleles) of C2

15) Confidence 0.51 Published 2007 Journal BMC Genet Section Body Doc Link PMC1853106 Disease Relevance 0 Pain Relevance 0

Neuropeptide expression in the human trigeminal nucleus caudalis and in the cervical spinal cord C1 and C2.

Gene_expression (expression) of C2 in nucleus associated with neuropeptide and spinal cord

16) Confidence 0.34 Published 2002 Journal Cephalalgia Section Title Doc Link 11972578 Disease Relevance 0.20 Pain Relevance 0.54

A mathematical modelling study by Keller et al. 42 found that an increase in kyphosis of 41.7º due to osteoporotic deformity resulted in a 25.2% reduction in spinal height and produced a 15.1cm anterior translation of C2.

Gene_expression (produced) of C2 in anterior associated with kyphosis

17) Confidence 0.27 Published 2004 Journal International Journal of Medical Sciences Section Body Doc Link PMC1074712 Disease Relevance 0.85 Pain Relevance 0.07

There are some data to suggest that altered substrate metabolism in the gastrointestinal mucosa may also influence CO2 production.

Gene_expression (production) of CO2

18) Confidence 0.24 Published 2000 Journal Crit Care Section Body Doc Link PMC137256 Disease Relevance 0.10 Pain Relevance 0

Clearly local metabolic factors that alter the position of the haemaglobin CO2 dissociation curve could result in changes in measured gastric CO2 in the absence of any alteration in local CO2 production.

Gene_expression (production) of CO2

19) Confidence 0.24 Published 2000 Journal Crit Care Section Body Doc Link PMC137256 Disease Relevance 0.20 Pain Relevance 0

Most of the early classical pathway complement genes, including C1 components (C1S, C1QA, C1QG, C1R), C2, and C4b, as well as a component of the late complement cascade (C7), were selectively expressed in both the corneal and ciliary body/iris tissues.

Gene_expression (expressed) of C2 in iris

20) Confidence 0.23 Published 2005 Journal Genome Biol Section Body Doc Link PMC1242209 Disease Relevance 0.17 Pain Relevance 0.11

General Comments

This test has worked.