INT44637

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Context Info
Confidence 0.55
First Reported 1984
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 7.27
Pain Relevance 1.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc9a3r2) nucleus (Slc9a3r2) cytoplasm (Slc9a3r2)
Anatomy Link Frequency
knee 3
joint 1
Medial 1
Slc9a3r2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Osteoarthritis 59 97.72 Very High Very High Very High
depression 4 96.24 Very High Very High Very High
Pain 139 90.80 High High
cva 22 80.04 Quite High
Regional anesthesia 5 78.16 Quite High
Pain management 22 76.88 Quite High
Arthritis 11 76.40 Quite High
backache 2 67.28 Quite High
Pain score 7 62.88 Quite High
anesthesia 18 10.64 Low Low
Disease Link Frequency Relevance Heat
Obesity 149 99.80 Very High Very High Very High
Arthropathy 1 99.06 Very High Very High Very High
Knee Osteoarthritis 12 97.72 Very High Very High Very High
Depression 4 96.24 Very High Very High Very High
Osteoarthritis 97 93.32 High High
Contracture 22 91.12 High High
Pain 166 90.80 High High
Postoperative Complications 1 89.44 High High
Disease 17 88.08 High High
Frailty 36 88.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, the patients in our study had a significantly greater return to sport rate after UKA than patients who had undergone TKA.
Positive_regulation (undergone) of TKA
1) Confidence 0.55 Published 2008 Journal Knee Surg Sports Traumatol Arthrosc Section Abstract Doc Link 18696051 Disease Relevance 0.08 Pain Relevance 0.08
Moreover, patients undergoing UKA also returned to sport more quickly than patients undergoing TKA.
Positive_regulation (undergoing) of TKA
2) Confidence 0.55 Published 2008 Journal Knee Surg Sports Traumatol Arthrosc Section Abstract Doc Link 18696051 Disease Relevance 0.07 Pain Relevance 0.07
Seventy-six patients had undergone TKA and 34 patients had undergone UKA.
Positive_regulation (undergone) of TKA
3) Confidence 0.37 Published 2008 Journal Knee Surg Sports Traumatol Arthrosc Section Abstract Doc Link 18696051 Disease Relevance 0 Pain Relevance 0
Results showed statistically significant decreases in joint position sense from young controls to old controls, and further significant decreases with joint disease; however, no further worsening was noted as a result of TKA.
Positive_regulation (result) of TKA in joint associated with arthropathy
4) Confidence 0.19 Published 1984 Journal J. Orthop. Res. Section Abstract Doc Link 6481511 Disease Relevance 0.24 Pain Relevance 0.08
This would lower the threshold for complaint in regards to their requirement for a TKA, making it slightly more difficult for clinicians to assess the scenario objectively.
Positive_regulation (requirement) of TKA
5) Confidence 0.04 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1552065 Disease Relevance 0.19 Pain Relevance 0.10
Through this study we were also able to identify if the SPSS was a good tool to prioritise patients requiring TKA.


Positive_regulation (requiring) of TKA
6) Confidence 0.04 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1552065 Disease Relevance 0 Pain Relevance 0
Total Knee Arthroplasty (TKA) operations are increasing in frequency, from 160,000 operations in 2003, to an estimate of 500,000 per year by 2030 [1,2].
Positive_regulation (increasing) of TKA in Knee
7) Confidence 0.02 Published 2008 Journal Cases J Section Body Doc Link PMC2615769 Disease Relevance 0.42 Pain Relevance 0
After institutional review board approval was obtained, the surgical records of a single tertiary hospital were reviewed to retrospectively identify all patients who underwent unilateral or simultaneous bilateral TKA by the senior authors (STG and RNS) between October 1997 and December 2007.
Positive_regulation (underwent) of TKA
8) Confidence 0.02 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2896355 Disease Relevance 0.80 Pain Relevance 0.07
During the 10-year study period, a total of 151 obese patients underwent unilateral TKA and 148 obese patients underwent simultaneous, 2-team TKA.
Positive_regulation (underwent) of TKA associated with obesity
9) Confidence 0.02 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2896355 Disease Relevance 0.94 Pain Relevance 0.08
However, despite the proliferation of published work relating to this topic, no absolute statement can be made regarding the relative risk of undergoing simultaneous bilateral TKA because of inconsistent terminology and variable study design.
Positive_regulation (undergoing) of TKA
10) Confidence 0.02 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2896355 Disease Relevance 0.80 Pain Relevance 0.08
The prevalence of bilateral knee osteoarthritis has been shown to be as high as 5%, which forces the patient and physician to confront the dilemma of whether to undergo TKA as a 1- or 2- stage procedure [2].
Spec (whether) Positive_regulation (undergo) of TKA in knee associated with knee osteoarthritis and osteoarthritis
11) Confidence 0.02 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2896355 Disease Relevance 0.28 Pain Relevance 0.10
To our best knowledge, this is the first well-documented case reporting early polyethylene failure in TKA caused by an impinging remnant meniscus.


Positive_regulation (caused) of TKA
12) Confidence 0.01 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC1945031 Disease Relevance 0.25 Pain Relevance 0.15
Patients aged between 50 and 80 years undergoing primary TKA without a history of prior open knee surgery qualified for enrollment.
Positive_regulation (undergoing) of TKA in knee
13) Confidence 0.01 Published 2010 Journal Int J Gen Med Section Body Doc Link PMC2962325 Disease Relevance 0.60 Pain Relevance 0.41
In this study, the odds of having a TKA increase by about 1.11 times for each year increase in age.
Positive_regulation (increase) of TKA
14) Confidence 0.01 Published 2008 Journal Skeletal Radiol Section Body Doc Link PMC2424184 Disease Relevance 1.16 Pain Relevance 0
Closure then was performed on the first TKA, and during this process, the surgeon communicated with the anesthesiologist to confirm the patient remained hemodynamically stable enough to undergo the second sequential TKA.
Positive_regulation (undergo) of TKA
15) Confidence 0.01 Published 2008 Journal Clin Orthop Relat Res Section Body Doc Link PMC2628493 Disease Relevance 0.14 Pain Relevance 0
Compared with before surgery, the changes at t3 and t6 on rising from a chair and self-reported physical functioning (WOMAC) were greater (p = 0.03 and p = 0.03) for patients undergoing THA than for patients undergoing TKA.


Positive_regulation (undergoing) of TKA
16) Confidence 0.01 Published 2008 Journal Clin Orthop Relat Res Section Body Doc Link PMC2492989 Disease Relevance 0.16 Pain Relevance 0.16
More patients were satisfied with the result of the TKA with the PFC Sigma mobile-bearing prosthesis than were satisfied with the result of the contralateral TKA with the Medial Pivot fixed-bearing prosthesis (Table 6).
Positive_regulation (result) of TKA in Medial
17) Confidence 0.01 Published 2008 Journal Clin Orthop Relat Res Section Body Doc Link PMC2628493 Disease Relevance 0.11 Pain Relevance 0
The data for this study come from the JRP at Verde Valley Medical Center, a 99-bed regional medical center in the rural Southwest. 87 consecutive patients were candidates for and underwent a primary TKA between April 2006 and November 2007.
Positive_regulation (underwent) of TKA
18) Confidence 0.00 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2596133 Disease Relevance 0.68 Pain Relevance 0.19
The purpose of this descriptive study was to describe a wellness-based, comprehensive program (the JRP) for patients undergoing TKA and to report post-surgical outcomes of 74 consecutive inpatients.
Positive_regulation (undergoing) of TKA
19) Confidence 0.00 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2596133 Disease Relevance 0.34 Pain Relevance 0.14

General Comments

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