INT4464

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Context Info
Confidence 0.80
First Reported 1975
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 21
Total Number 22
Disease Relevance 8.09
Pain Relevance 3.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CEL) extracellular space (CEL) small molecule metabolic process (CEL)
extracellular region (CEL) lipid metabolic process (CEL) cytoplasm (CEL)
Anatomy Link Frequency
sputum 3
mast cell 3
mammary glands 1
blood 1
liver 1
CEL (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 100 100.00 Very High Very High Very High
cytokine 92 100.00 Very High Very High Very High
Dynorphin 7 100.00 Very High Very High Very High
Enkephalin 4 100.00 Very High Very High Very High
bradykinin 2 99.76 Very High Very High Very High
ischemia 5 99.60 Very High Very High Very High
substance P 12 99.08 Very High Very High Very High
opiate 3 96.72 Very High Very High Very High
Angina 2 95.60 Very High Very High Very High
tolerance 1 91.68 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 114 100.00 Very High Very High Very High
Disease 38 100.00 Very High Very High Very High
Sickle Cell Anemia 10 100.00 Very High Very High Very High
Myeloid Leukemia 12 99.90 Very High Very High Very High
Mycobacterial Infection 99 99.84 Very High Very High Very High
Cv Unclassified Under Development 5 99.60 Very High Very High Very High
Asthma 24 99.56 Very High Very High Very High
Toxicity 8 99.30 Very High Very High Very High
Pulmonary Eosinophilia 1 98.72 Very High Very High Very High
Eosinophilia 16 98.02 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CEase is also synthesized in lactating mammary glands and is secreted into milk in a number of species including human.
Localization (secreted) of CEase in mammary glands
1) Confidence 0.80 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC406500 Disease Relevance 0.07 Pain Relevance 0.05
These results demonstrate that PDN transcription is regulated by DREAM in a calcium-dependent manner and suggest a role for dynorphin regulation of alpha-cell glucagon secretion.
Localization (secretion) of cell associated with dynorphin
2) Confidence 0.78 Published 2006 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 16621893 Disease Relevance 0 Pain Relevance 0.34
Our objectives were to characterize the acute toxicity of DAPM in liver, particularly on secretion of biliary constituents and on biliary epithelial cell gamma-glutamyl transpeptidase (GGT) activity.
Localization (secretion) of cell in liver associated with toxicity
3) Confidence 0.78 Published 1992 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 1440618 Disease Relevance 0.30 Pain Relevance 0.23
FBS- and PDGF-BB-stimulated intracellular Ras, MEK1/2, ERK1/2, proliferative cell nuclear antigen (PCNA), and Akt activations were significantly inhibited by lercanidipine; however, lercanidipine did not affect FBS- and PDGF-BB-induced STAT3 phosphorylation.
Localization (antigen) of cell
4) Confidence 0.73 Published 2009 Journal Pharmacol. Res. Section Abstract Doc Link 18973813 Disease Relevance 0.40 Pain Relevance 0.15
The other patient, with sickle cell hemoglobin Hb A, S, and (Hb) C disease, also achieved an 80% exchange calculated on the level of HbA.S.
Localization (disease) of cell associated with sickle cell anemia and disease
5) Confidence 0.73 Published 1975 Journal JAMA Section Abstract Doc Link 1173102 Disease Relevance 0.80 Pain Relevance 0.09
The relatively mild early clinical course of sickle cell-hemoglobin C disease indicates that neonatal diagnosis does not have the same urgency as for homozygous sickle cell disease.
Localization (disease) of cell associated with sickle cell anemia and disease
6) Confidence 0.73 Published 1986 Journal J. Pediatr. Section Abstract Doc Link 3761071 Disease Relevance 0.87 Pain Relevance 0.09
PATIENTS AND METHODS: The secretion of the mast cell mediators histamine and tryptase was followed from biopsies of patients with and without premedication for 30 minutes in an air-bubbled incubation medium (mucosa oxygenation).
Localization (secretion) of cell in mast cell
7) Confidence 0.68 Published 1995 Journal Endoscopy Section Body Doc Link 8549437 Disease Relevance 0 Pain Relevance 0
These studies clearly indicate cell-specific processing of proenkephalin, and suggest that the T helper cell-secreted products may have nonopiate receptor-mediated actions.
Localization (secreted) of cell
8) Confidence 0.68 Published 1989 Journal FASEB J. Section Abstract Doc Link 2529160 Disease Relevance 0 Pain Relevance 0.25
Collectively, our findings indicate that an important link exists in the heart between sensory nerves and renin-containing mast cells; substance P released from sensory nerves plays a significant role in the release of mast cell renin in ischemia/reperfusion and in the activation of a local cardiac RAS.
Localization (release) of cell in sensory nerves associated with ischemia and substance p
9) Confidence 0.68 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20668055 Disease Relevance 0.34 Pain Relevance 0.58
Therefore, production of prostaglandins, thromboxanes, and, possibly, leukotrienes in the renal cortex by the constituent cells of the glomeruli and the arterioles would be anticipated to influence their hemodynamic functions, that is, glomerular filtration rate, renal blood flow, renal vascular resistance, and juxtaglomerular granular cell renin release.
Localization (release) of cell in blood
10) Confidence 0.68 Published 1986 Journal Am. J. Med. Section Abstract Doc Link 3511683 Disease Relevance 0.15 Pain Relevance 0.18
Effects of enhanced counterpulsation on vascular cell release of coagulation factors.
Localization (release) of cell
11) Confidence 0.68 Published 2005 Journal Heart Lung Section Title Doc Link 16027645 Disease Relevance 0.19 Pain Relevance 0.14
The peptide classes studied were angiotensin, bradykinin, alpha-bag cell factor, beta,gamma-bag cell factor, beta-casomorphin, dynorphin, enkephalin, leucokinin, lutinizing hormone releasing hormone, neurotinsin, substance P, and vasopressin.
Localization (releasing) of cell associated with dynorphin, enkephalin, bradykinin and substance p
12) Confidence 0.68 Published 2004 Journal J Chromatogr A Section Abstract Doc Link 15543975 Disease Relevance 0 Pain Relevance 0.25
The peptide classes studied were angiotensin, bradykinin, alpha-bag cell factor, beta,gamma-bag cell factor, beta-casomorphin, dynorphin, enkephalin, leucokinin, lutinizing hormone releasing hormone, neurotinsin, substance P, and vasopressin.
Localization (releasing) of cell associated with dynorphin, enkephalin, bradykinin and substance p
13) Confidence 0.68 Published 2004 Journal J Chromatogr A Section Abstract Doc Link 15543975 Disease Relevance 0 Pain Relevance 0.25
Mast cell tryptase and histamine release were analyzed immunoenzymatically.
Spec (analyzed) Localization (release) of cell in Mast cell
14) Confidence 0.68 Published 2004 Journal Gastroenterology Section Body Doc Link 14988823 Disease Relevance 0.09 Pain Relevance 0
PAR-2-mediated intestinal electrolyte secretion by release of mast cell tryptase and potentiation of PAR-2 expression by tumor necrosis factor-alpha may contribute to the hypersecretion observed in inflammatory processes such as chronic inflammatory bowel disease.
Localization (release) of cell in bowel associated with necrosis, inflammation and cancer
15) Confidence 0.68 Published 2002 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11804840 Disease Relevance 0.65 Pain Relevance 0.31
CML and CEL were normalized to the lysine content of the sample.


Localization (normalized) of CEL associated with myeloid leukemia
16) Confidence 0.40 Published 2007 Journal J Inherit Metab Dis Section Body Doc Link PMC2799632 Disease Relevance 0.29 Pain Relevance 0.06
Preparation of BAL cytospins was the same as the preparation of IS samples described above.


Localization (Preparation) of BAL
17) Confidence 0.28 Published 2007 Journal Respir Res Section Body Doc Link PMC2200652 Disease Relevance 0 Pain Relevance 0.21
Bronchoalveolar lavage (BAL)
Localization (lavage) of BAL
18) Confidence 0.24 Published 2010 Journal Crit Care Section Body Doc Link PMC2887148 Disease Relevance 0.28 Pain Relevance 0.09
1b to DOTS in a randomized, controlled clinical trial resulted in reduced BAL cytokines, more rapid clearance of Mtb from the sputum, improved symptoms, and reduced inflammatory macrophage-neutrophil alveolitis.
Localization (clearance) of BAL in sputum associated with mycobacterial infection, inflammation and cytokine
19) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737621 Disease Relevance 0.60 Pain Relevance 0.29
1b was successful in clearing the sputum of Mtb and reducing the spontaneous release of inflammatory cytokines in 24 hour BAL supernatants.
Localization (release) of BAL in sputum associated with mycobacterial infection, inflammation and cytokine
20) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2737621 Disease Relevance 0.63 Pain Relevance 0.10

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