INT4465

Context Info Confidence 0.77 First Reported 1975 Last Reported 2011 Negated 3 Speculated 5 Reported most in Abstract Documents 116 Total Number 124 Disease Relevance 98.35 Pain Relevance 23.58

cytosol (CEL) extracellular space (CEL) small molecule metabolic process (CEL) extracellular region (CEL) lipid metabolic process (CEL) cytoplasm (CEL)

Anatomy Link Frequency T-cell 13 macrophages 7 B-cell 7 endothelial cell 5 mast cell 5 CEL (Homo sapiens)

Pain Link Frequency Relevance Heat metalloproteinase 782 100.00 cytokine 590 100.00 substance P 18 100.00 Neuropeptide 11 100.00 Neurotransmitter 7 100.00 Enkephalin 4 100.00 opioid receptor 10 99.98 rheumatoid arthritis 86 99.96 bradykinin 1 99.84 depression 10 99.76

Disease Link Frequency Relevance Heat Cancer 441 100.00 Disease 293 100.00 Rheumatoid Arthritis 87 100.00 Necrosis 80 100.00 Adhesions 76 100.00 Sickle Cell Anemia 26 100.00 Skin Cancer 14 100.00 Thymoma 4 100.00 Neuroblastoma 1 100.00 Glioma 180 99.98

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This apparent broad distribution of CEase expression, however, has been questioned in a recent report of tissue levels of CEase mRNA in which only pancreatic and intestinal tissues were positive [18].

Gene_expression (expression) of CEase

1) Confidence 0.77 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC406500 Disease Relevance 0.29 Pain Relevance 0.09

CEase is also synthesized in lactating mammary glands and is secreted into milk in a number of species including human.

Gene_expression (synthesized) of CEase in mammary glands

2) Confidence 0.77 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC406500 Disease Relevance 0.06 Pain Relevance 0.05

In pancreatitis there was an increased expression of FAP protein in the acinar tissue in relation to inflammatory changes.

Gene_expression (expression) of FAP protein associated with inflammation and pancreatitis

3) Confidence 0.77 Published 1990 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 2403740 Disease Relevance 1.10 Pain Relevance 0.20

In cases of primary pancreatic adenocarcinoma and metastatic tumors in the pancreas, a strong expression of FAP protein in the peritumoral acinar area was found.

Gene_expression (expression) of FAP protein in pancreas associated with adenocarcinoma and metastasis

4) Confidence 0.77 Published 1990 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 2403740 Disease Relevance 1.09 Pain Relevance 0.20

METHODS: Using intravital microscopy we examined the ocular inflammatory response after the onset of arthritis in mice that overexpressed the T cell receptor (TCR) specific for a dominant arthritogenic epitope of cartilage proteoglycan [TCR-Tg (transgenic) mice] or BALB/c controls.

Gene_expression (overexpressed) of cell in T cell

5) Confidence 0.75 Published 2008 Journal Ophthalmic Res. Section Body Doc Link 18421237 Disease Relevance 0.19 Pain Relevance 0

RESULTS: Significantly lower expression of PAR-1 and higher expression of mast cell tryptase was detected in the colons of patients, with statistically unchanged expression of PAR-2.

Gene_expression (expression) of cell in colons

6) Confidence 0.75 Published 2009 Journal J. Gastroenterol. Section Body Doc Link 19430717 Disease Relevance 0.08 Pain Relevance 0

FLS isolated from patients with RA (FLS-RA) express B cell-activating factor belonging to the TNF family (BAFF), a cytokine that has been associated with the onset and progression of RA.

Gene_expression (express) of cell in B cell associated with rheumatoid arthritis and cytokine

7) Confidence 0.75 Published 2008 Journal Cytokine Section Abstract Doc Link 18316202 Disease Relevance 0.81 Pain Relevance 0.67

Thereafter, the expression of platelet derived endothelial cell growth factor/thymidine phosphorylase (PDECGF/TP) was measured by enzyme-linked immunosorbent assay.

Gene_expression (expression) of cell in platelet

8) Confidence 0.75 Published 2004 Journal J. Urol. Section Body Doc Link 15311005 Disease Relevance 0.17 Pain Relevance 0

Similarly, responses of T cells are depressed by morphine, as assessed by inhibition of induction of delayed-type hypersensitivity reactions and cytotoxic T-cell activity, modulation of T-cell antigen expression, and depression of responses to T-cell mitogens.

Gene_expression (expression) of cell in cytotoxic T-cell associated with depression, hypersensitivity and morphine

9) Confidence 0.75 Published 1998 Journal J. Neuroimmunol. Section Abstract Doc Link 9610671 Disease Relevance 0.29 Pain Relevance 0.64

In order to know whether chronic fluoxetine treatment induces differential neuronal structural plasticity in rats, we have analyzed the expression of synaptophysin, a protein considered a marker of synaptic density, and the expression of the polysialylated form of the neural cell adhesion molecule (PSA-NCAM), a molecule involved in neurite and synaptic remodeling.

Spec (analyzed) Gene_expression (expression) of cell in neuronal associated with adhesions and fluoxetine

10) Confidence 0.75 Published 2007 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 17307340 Disease Relevance 0.19 Pain Relevance 0.48

Many different drugs, including non-steroidal anti-inflammatory drugs (NSAIDs), glucocorticoids, rheumatoid arthritis disease-modifying agents and phosphodiesterase inhibitors, interfere with the expression and/or function of cell adhesion receptors and this effect accounts for, at least in part, their anti-inflammatory activity.

Gene_expression (expression) of cell associated with inflammation, rheumatoid arthritis, cinod, disease and adhesions

11) Confidence 0.75 Published 2001 Journal Expert Opin Pharmacother Section Abstract Doc Link 11336564 Disease Relevance 1.05 Pain Relevance 0.53

Although there is virtually no information regarding the regulation of expression of endothelial cell adhesion molecules (ECAMs) in experimental NSAID-induced gastropathy, the nuclear transcription factor KB (NFKB) may represent a potential modulator of transcriptional activation of ECAM expression.

Gene_expression (expression) of cell in endothelial cell associated with cinod and adhesions

12) Confidence 0.75 Published 1998 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 9872503 Disease Relevance 0.39 Pain Relevance 0.25

Immunocytochemical techniques was used to compare the proportion of neurons expressing various neurotransmitters (tyrosine hydroxylase, choline acetyltransferase and gamma-aminobutyric acid), neuropeptides (Leu-enkephalin and substance P) and neural cell adhesion molecules (NCAM) in the hippocampus, frontal (area 10) and occipital (area 17) cortices of neurologically normal elderly humans to that of age-matched Alzheimer disease (AD) patients.

Gene_expression (expressing) of cell in neural associated with neurotransmitter, alzheimer's dementia, neuropeptide, hippocampus, enkephalin, adhesions and substance p

13) Confidence 0.75 Published 1999 Journal Exp. Gerontol. Section Abstract Doc Link 10197733 Disease Relevance 0.57 Pain Relevance 0.38

Eleven patients (7.0%) with persisting (partial) villous atrophy were considered to have RCD; 5 of them developed EATL [27].RCD type I is characterized by normal expression of T-cell antigens and polyclonal TCR gene rearrangement.RCD type II is characterized by an abnormal IEL phenotype with the expression of intracytoplasmic CD3e, surface CD103, and the lack of classic surface T-cell markers such as CD8, CD4, and TCR-alpha/beta.

Gene_expression (expression) of cell in T-cell associated with frailty

14) Confidence 0.75 Published 2006 Journal Gastrointest. Endosc. Clin. N. Am. Section Abstract Doc Link 16644460 Disease Relevance 1.22 Pain Relevance 0.03

The cells of the subcapsular, endocrine RE cell layer (giant or nurse cells), characterized by PAS positive granules, express A2B5/TE4 cell surface antigens and MHC Class I (HLA A, B, C) molecules.

Gene_expression (express) of cell in nurse cells

15) Confidence 0.75 Published 1999 Journal In Vivo Section Abstract Doc Link 10459506 Disease Relevance 0 Pain Relevance 0

We investigated the intracellular mechanism by which morphine controls CD4+ T cell differentiation and demonstrate that morphine treatment in vitro 1) increases anti CD3/CD28 Ab-induced CD4+ T cell IL-4 protein synthesis, IL-4 mRNA, and GATA-3 mRNA accumulation through a pertussis toxin-sensitive receptor; 2) results in a dose-dependent increase in anti-CD3/CD28 Ab-induced CD4+ T cell cytoplasmic cAMP concentration; and 3) increases the forskolin-stimulated cytoplasmic cAMP level through a pertussis toxin-sensitive receptor.

Gene_expression (synthesis) of cell in T cell associated with bordatella infection and morphine

16) Confidence 0.75 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16272288 Disease Relevance 0.42 Pain Relevance 0.56

Morphine induces CD4+ T cell IL-4 expression through an adenylyl cyclase mechanism independent of the protein kinase A pathway.

Gene_expression (expression) of cell in T cell associated with morphine

17) Confidence 0.75 Published 2005 Journal J. Immunol. Section Title Doc Link 16272288 Disease Relevance 0.39 Pain Relevance 0.50

METHODS: Human Jurkat T-lymphoma cells overexpressing the antiapoptotic protein B-cell lymphoma 2 as well as cells deficient of caspase 9, caspase 8, or Fas-associated protein with death domain were exposed to lidocaine and compared with parental cells.

Gene_expression (overexpressing) of cell in B-cell

18) Confidence 0.75 Published 2007 Journal Anesthesiology Section Body Doc Link 17585225 Disease Relevance 0.10 Pain Relevance 0

PML-RAR alpha with intron 3 breakpoint of the PML locus, and rearrangements of the T-cell receptor beta and gamma genes were detected.

Gene_expression (detected) of cell in T-cell

19) Confidence 0.75 Published 1996 Journal Rinsho Ketsueki Section Abstract Doc Link 8997125 Disease Relevance 0.92 Pain Relevance 0.11

In contrast, stromal cell-derived factor (SDF)-1alpha, macrophage inflammatory protein (MIP)-1alpha and -1beta were not detectable in conditioned media of synovial fibroblasts, with or without TNF-alpha treatment.

Neg (not) Gene_expression (detectable) of cell in stromal cell

20) Confidence 0.75 Published 2005 Journal J. Oral Pathol. Med. Section Body Doc Link 15946184 Disease Relevance 0.16 Pain Relevance 0

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