INT44661

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Context Info
Confidence 0.45
First Reported 1981
Last Reported 2010
Negated 3
Speculated 4
Reported most in Body
Documents 15
Total Number 20
Disease Relevance 12.69
Pain Relevance 2.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

immune system process (Ahr) cell morphogenesis (Ahr) DNA binding (Ahr)
response to stress (Ahr) cytoplasm (Ahr) signal transducer activity (Ahr)
Anatomy Link Frequency
neurons 2
smooth muscle 1
eosinophil 1
lung 1
oocyte 1
Ahr (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 95 100.00 Very High Very High Very High
agonist 16 99.96 Very High Very High Very High
Inflammation 188 99.82 Very High Very High Very High
nMDA receptor 2 99.68 Very High Very High Very High
Paracetamol 14 96.68 Very High Very High Very High
anesthesia 25 84.56 Quite High
corticosteroid 14 82.56 Quite High
Arthritis 2 82.52 Quite High
fibrosis 13 81.80 Quite High
rheumatoid arthritis 1 81.52 Quite High
Disease Link Frequency Relevance Heat
Asthma 471 100.00 Very High Very High Very High
Bronchitis 11 100.00 Very High Very High Very High
Airway Remodeling 50 99.84 Very High Very High Very High
INFLAMMATION 197 99.82 Very High Very High Very High
Nicotine Addiction 86 99.00 Very High Very High Very High
Obesity 338 98.76 Very High Very High Very High
Weight Gain 12 98.56 Very High Very High Very High
Drug Induced Neurotoxicity 31 95.88 Very High Very High Very High
Weight Loss 17 94.92 High High
Targeted Disruption 29 94.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of age on hepatic glutathione (GSH) levels and aryl hydrocarbon hydroxylase (AHH) activity and the ability of these mice to respond to the acute administration of acetaminophen (AAP) has been studied.
Regulation (effect) of aryl hydrocarbon hydroxylase associated with paracetamol
1) Confidence 0.45 Published 1981 Journal Drug Chem Toxicol Section Abstract Doc Link 7261945 Disease Relevance 0 Pain Relevance 0.47
The effect of age on hepatic glutathione (GSH) levels and aryl hydrocarbon hydroxylase (AHH) activity and the ability of these mice to respond to the acute administration of acetaminophen (AAP) has been studied.
Regulation (effect) of AHH associated with paracetamol
2) Confidence 0.45 Published 1981 Journal Drug Chem Toxicol Section Abstract Doc Link 7261945 Disease Relevance 0 Pain Relevance 0.47
To examine in vivo responses of the sensor mice to AhR agonists, we administered 5 ?
Spec (examine) Regulation (responses) of AhR associated with agonist
3) Confidence 0.45 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2265056 Disease Relevance 0.38 Pain Relevance 0.05
The effect of intraovarian (io) injection of benzo(a)pyrene (BP) on primordial oocyte number, ovarian aryl hydrocarbon hydroxylase (AHH, EC 1.14.14.1) activity, and hepatic AHH activity and P-450 content was investigated in C57BL/6N (B6) and DBA/2N (D2) mice.
Spec (investigated) Regulation (effect) of AHH in oocyte
4) Confidence 0.44 Published 1984 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 6484988 Disease Relevance 0.05 Pain Relevance 0.08
There have been several other examples in which transfected AhR has been found to be active in the host cells [56,57], although it remains unclear why ligand-dependent AhR is activated under conditions in the absence of either ligand or TCDD.
Regulation (dependent) of AhR
5) Confidence 0.43 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0.58 Pain Relevance 0.03
AhR, CYP1A1 and cdc42 mRNA expression were quantified in AhR by real-time PCR.
Regulation (quantified) of AhR
6) Confidence 0.43 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0 Pain Relevance 0
To investigate the significance of the AhR pathway activation following ?
Spec (investigate) Regulation (significance) of AhR
7) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816705 Disease Relevance 0.22 Pain Relevance 0
in asthma has been suggested by various animal studies, showing alteration of the contractile properties of the airway smooth muscle18 and regulation of AHR and neutrophilia.19 Furthermore, TNF-?
Regulation (regulation) of AHR associated with asthma
8) Confidence 0.39 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2730622 Disease Relevance 1.24 Pain Relevance 0.33
AhR, CYP1A1 and cdc42 mRNA expression were quantified in AhR by real-time PCR.
Regulation (quantified) of AhR
9) Confidence 0.38 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0 Pain Relevance 0
The observed up-regulation of AHR-responsive genes in lung tissue of smokers is likely mediated by the activation of AHR.
Regulation (regulation) of AHR-responsive in lung associated with nicotine addiction
10) Confidence 0.31 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.24 Pain Relevance 0
The influence of the AhR on the developing neuron was assessed using the Neuro2a-AhR transfectant.
Regulation (influence) of AhR in neuron
11) Confidence 0.26 Published 2006 Journal Environ Health Section Abstract Doc Link PMC1570454 Disease Relevance 0.27 Pain Relevance 0.03
Recent studies have revealed that AhR activity in central neurons depends on the NMDA receptor.
Regulation (depends) of AhR in neurons associated with nmda receptor
12) Confidence 0.26 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 17973980 Disease Relevance 0.16 Pain Relevance 0.29
Bradding suggested that a major factor in asthmatic AHR and airway smooth muscle (ASM) dysfunction seen in asthma but not in EB is likely due to the presence of smooth muscle-infiltrating mast cells in asthma, which is absent in EB [1].
Spec (likely) Regulation (due) of AHR in smooth muscle associated with asthma and bronchitis
13) Confidence 0.25 Published 2008 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2868889 Disease Relevance 1.75 Pain Relevance 0.11
The regulated expression of FBLN-1 downstream of inflammation and its regulation of the remodeling/AHR axis identify the therapeutic potential of targeting this glycoprotein.
Regulation (regulation) of AHR associated with inflammation
14) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 0.71 Pain Relevance 0.13
Role of cytokines and mediators in AHR
Regulation (Role) of AHR associated with cytokine
15) Confidence 0.25 Published 2005 Journal Respir Res Section Body Doc Link PMC1325022 Disease Relevance 0.87 Pain Relevance 0.23
Ab treatment did not reveal an inhibitory effect on TH1 mediated airway neutrophilia and AHR.
Regulation (effect) of AHR
16) Confidence 0.25 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.73 Pain Relevance 0.22
Our studies using an anti-Siglec-F Ab in a model of chronic OVA allergen induced airway remodeling also demonstrated inhibition of airway remodeling but no effect on AHR measurements [15], consistent with our observations in this study using Siglec-F deficient mice.
Neg (no) Regulation (effect) of AHR associated with airway remodeling
17) Confidence 0.25 Published 2010 Journal Respir Res Section Body Doc Link PMC2988013 Disease Relevance 0.69 Pain Relevance 0
Notably, this is, to our knowledge, the first report demonstrating that inhibition of a matrix protein reduces AHR, thereby providing direct evidence for the role of the ECM in regulating AHR in this model.
Regulation (regulating) of AHR
18) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954173 Disease Relevance 0.60 Pain Relevance 0.11
Without demonstrable correlation between obesity and airway inflammation, it has been, therefore, speculated that the epidemiological association between obesity and asthma is primarily due to ventilatory mechanics rather than an inflammatory one.54 King et al55 observed a significant decrease in airway caliber with increasing weight but observed no change in AHR or asthma rates.
Neg (no) Regulation (change) of AHR associated with asthma, inflammation and obesity
19) Confidence 0.12 Published 2010 Journal Int J Gen Med Section Body Doc Link PMC2990395 Disease Relevance 1.99 Pain Relevance 0.15
However, there are no changes in AHR or inhaled nitric oxide.51,52 BMI does not seem to affect eosinophil counts or serum IgE levels either.53
Neg (no) Regulation (changes) of AHR in eosinophil associated with obesity
20) Confidence 0.12 Published 2010 Journal Int J Gen Med Section Body Doc Link PMC2990395 Disease Relevance 2.20 Pain Relevance 0.08

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